Recombinant Mouse Receptor-type tyrosine-protein phosphatase C (Ptprc), partial

1. Inhibition by high CD45 on CD8(+) T cells may protect against overt T-cell receptor (TCR) auto-MHC reactivity. PMID: 27841348
2. this study shows that CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia PMID: 27579617
3. Data show that CD45(+) uncultured adipose tissue derived stromal cells (u-ADSCs) acting phenotypically and functionally like M2-type macrophages (MPhis), contributed to the repair of liver tissue undergoing inflammation. PMID: 28891216
4. We identify differing roles for the phosphatase CD45 in innate and adaptive immune cells in intestinal inflammation. CD45 is required for optimal GM-CSF and RA production in innate immune cells that affects alpha4beta7 expression and the homing of effector T cells to the intestine. Conversely, the absence of CD45 on adaptive immune cells leads to enhanced alpha4beta7 expression on T cells and homing to the intestine. PMID: 27007678
5. T cell receptor / TLR2 co-stimulation expands CD25+CD45Rbhi T cells. PMID: 28742882
6. Increased numbers of CD4(+)CD45RA(-)FoxP3(low) cells may cause an imbalance between Treg and Th17 cells that is mainly localized to the colon. PMID: 27895423
7. Use of the common leukocyte marker CD45 increases the sensitivity of the diagnosis of lymphocytic myocarditis. PMID: 28025077
8. Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34+/CD45- muscle derived stem cells. PMID: 26655331
9. deletion of Pten in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies PMID: 26773036
10. A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR) signaling through modulation of the function of the inhibitory coreceptor CD22, was identified. PMID: 26561584
11. data demonstrate that the CD45E613R mutation modulates integrin activation and leukocyte recruitment during inflammation. PMID: 25505282
12. CD45 ligation specifically reduced Treg motility in an integrin-dependent manner, resulting in enhanced interactions between Tregs and DCs in vivo. PMID: 25202978
13. Data (including data from genome-wide mutagenesis studies) suggest that nonsense mutation in Ptprc is a susceptibility trait for herpes simplex encephalitis due to Herpesvirus 1; this effect appears to be mediated by Th1 cells and the brain stem. PMID: 24068938
14. These findings demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation and suggest that innate immune cells may communicate with stromal cells to regulate IL-7 production. PMID: 25114101
15. Expressing CD45 promoters containing these regions and tethered to green fluorescent protein (GFP) in a primary B-cell differentiation assay and a transplantation model resulted in high levels of GFP in lymphoid, myeloid, and nucleated erythroid cells PMID: 24852660
16. identified a novel CD45 phosphorylation event in hematopoietic progenitor cells that correlated with motile response and governed by the chemotactic factor CXCL12 PMID: 23997015
17. These data indicate that the alteration in the ratio of CD45.1 and CD45.2 B cell subsets in mixed chimera mice is a cell-intrinsic effect. PMID: 23928494
18. The large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering. PMID: 23580664
19. CD11c+B220+CD122+ cells play an important role in xenograft rejection. Their absence in NOG mice may be critical in supporting the successful engraftment of xenotransplants. PMID: 23018460
20. CD19positive CD45R(lo)positive lymphocytes of embryonic origin are present in Peyer's patches and in the spleen throughout the life span of wild-type mice, beginning at postnatal day 7. PMID: 22837485
21. Relative quantitative real time PCR (RT-PCR) of 64 genes revealed that mSPCD45(-) compared with mSPCD45(+) was enriched for cells expressing transcripts associated with endothelial cells, Notch signaling and myogenic precursors PMID: 21990046
22. beta-defensin 14 expression by tumor-infiltrating host cells chemoattracts B220-positive lymphocytes in a CCR6-dependent manner, initiating angiogenesis and development of organized tumor tissue. PMID: 22504651
23. These findings reveal how CD45 function diverges in T cells and B cells. PMID: 22135465
24. CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways. PMID: 22078799
25. The pan-leukocyte CD45 phosphatase plays an essential role in trafficking and repopulation of the bone marrow by immature human CD34(+) cells and leukemic cells in transplanted nonobese diabetic severe combined immunodeficient mice. PMID: 21911094
26. Syk, but not Zap70, controls the remaining CD45-independent, immunoreceptor tyrosine-based activation motif -specific NK-cell functions. PMID: 21245479
27. CD45 expression was required for the modulation of T cell death and proliferation induced by galactoxylomannan. PMID: 20856869
28. CD4-positiveCD45RB(low) cells and CD8-positiveCD122-positive regulatory T cells synergistically work to suppress colitis in a mouse model. PMID: 21098236
29. Data show that CD45 deficiency affects the development and progression of DN1 thymocytes. PMID: 20624943
30. The shift to high molecular weight CD45 isoforms in RNA-binding proteiin heterogeneous nuclear ribonucleoprotein L (Hnrpll) transgenic thymocytes does not demonstrably affect expression of CD45RA and -RC isoforms. PMID: 20505149
31. CD45 regulates thymocyte survival during development in fetal thymic organ culture. PMID: 19765855
32. show that relative titration of CD45 and Csk expression reveals distinct regulation of basal and inducible T cell receptor signaling during thymic development. PMID: 20346773
33. regulation of galectin-1 signaling by alpha2,6-sialylation of N-glycans is not solely dependent on CD45 phosphatase activity PMID: 19920154
34. These data indicate that CD45 is essential to the accumulation of CD4(-)/CD8(-) (DN) T cells in Fasl(gld/gld) mice PMID: 11716526
35. Role of high and low molecular weight isoforms of CD45 in the function of naive and memory T lymphocytes. Review. PMID: 12022705
36. The extracellular and/or the transmembrane portion of CD45 has a major role in apoptosis signaling which is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein. PMID: 12055218
37. Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. PMID: 12091326
38. CD22 binding to native CD45 PMID: 12115612
39. Segregation of CD45 from proximal TCR signaling components is necessary for TCR signaling and that the targeting of CD45 PTP activity to lipid microdomains on the T cell surface results in decreased sensitivity of TCR-mediated signaling. PMID: 12207342
40. CD45 is present in lipid rafts in T cells before activation, perhaps to activate raft-associated p56(lck), allowing membrane-proximal signaling events to proceed. PMID: 12391219
41. the large CD45 ectodomain is required for optimal TCR signaling PMID: 12496963
42. CD45 is regulated by ST6Gal I sialyltransferase in a process that leads to T cell death PMID: 12499376
43. The inhibitory function of PAG in T cells is suppressed by CD45. PMID: 12612075
44. the primary function of CD45 is inhibition of Src-PTKs and that the level of Src-PTK activation and the B-cell fate are determined in part by dynamic behavior of CD45 with respect to glycolipid microdomains PMID: 14563648
45. CD45-D2 has a role in binding substrate and binds the SD10 region in Lck, which is a novel site involved in substrate recognition PMID: 14625311
46. results support a model in which binding of CD45-AP to inactive CD45 dimers converts them to active monomers PMID: 14715639
47. an increase in the percentage of CD45- multiple myeloma cells preceded the angiogenic switch PMID: 15070695
48. de novo synthesis of CD45 results in a peanut agglutinin high phenotype in CD8+ T cells PMID: 15210702
49. The characterization of T and B cell populations in the distinct compartments of the gut mucosa and gut-associated lymphoid tissue of CD45-null mice. PMID: 15557316
50. A novel mechanism is described by which lipid raft-excluded CD45 positively regulates T cell receptor signal transduction and IL-2 production. PMID: 15661907

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KEGG: mmu:19264

STRING: 10090.ENSMUSP00000027645

UniGene: Mm.391573