Recombinant Mouse Receptor tyrosine-protein kinase erbB-2(Erbb2),partial

Code CSB-YP007763MO
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Source Yeast
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Code CSB-EP007763MO
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Source E.coli
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Code CSB-EP007763MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007763MO
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Source Baculovirus
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Code CSB-MP007763MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Erbb2
Uniprot No. P70424
Alternative Names Erbb2; Kiaa3023; NeuReceptor tyrosine-protein kinase erbB-2; EC 2.7.10.1; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; p185erbB2; CD antigen CD340
Species Mus musculus (Mouse)
Protein Length Extracellular domain
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Gene References into Functions
  1. High HER2 expression is associated with metastasis in breast Cancer. PMID: 29187405
  2. Study shows that within endoplasmic reticulum-related subsurface cistern, sigma-1 receptors, Kv2.1 and neuregulin-1 are clustered in highly specific, non-overlapping, microdomains, whereas ErbB2 and ErbB4 are present in the adjacent presynaptic compartment. This organization may define highly ordered and spatially restricted sites for different signal-transduction pathways. PMID: 28065942
  3. ErbB2 interacts with Nrp1 to form a Sema3d co-receptor expressed by developing coronary endothelium and required for proper connections of the forming coronary veins to the right atrium. PMID: 27356767
  4. The objective of this study was to determine if loss of Stard13 plays a role in mammary tumor progression using transgenic mice expressing the activated ErbB-2 (Neu) oncogene and Cre recombinase (NIC) in mammary epithelium under transcriptional control of the murine mammary tumor virus (MMTV) promoter (MMTV-NIC). PMID: 29218825
  5. Over-expression of HER2 remarkably enhanced the proliferation, invasion and migration of B16 cells. PMID: 28871948
  6. Results indicate the importance of the LDL receptor (LDLR) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C). PMID: 28759039
  7. caErbB2 markedly enhances regeneration of damaged dorsal roots, while evoking little change in intact roots PMID: 28982707
  8. immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb. PMID: 28855210
  9. We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110alpha inhibition. PMID: 28783168
  10. sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy PMID: 27538857
  11. investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation. PMID: 28067668
  12. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators. PMID: 27390088
  13. Despite previous evidence suggesting that ErbB receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS pathway in mouse breast cancer model. PMID: 27765041
  14. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis PMID: 26423570
  15. Study showed that suppression of STAT3, STAT5, and STAT6 and overexpression of the proapoptotic factor STAT1, which provides p53-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 PMID: 27417725
  16. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity PMID: 26692570
  17. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha-VEGF signaling axis in mediating HER2-induced tumor angiogenesis. PMID: 26625311
  18. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer. PMID: 26791520
  19. ErbB2 receptor tyrosine kinase in AECs was activated by annexin V, and blockade reduced the fibrotic potential of annexin V-treated AEC-conditioned medium. PMID: 26160872
  20. Disabling of the erbB pathway followed by IFNg modifies phenotype and enhances genotoxic eradication of breast tumors. PMID: 26365188
  21. Ptk6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse. PMID: 26247733
  22. PTPN12-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties. PMID: 26391955
  23. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. PMID: 26254336
  24. These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling PMID: 25875008
  25. the Krt6a-positive subset of mammary epithelial cells can be induced to form cancer by ErbB2. PMID: 25635772
  26. These results suggested that DS/Cu treatment may be a promising therapy for the prevention of erbB2-positive breast cancer PMID: 25738885
  27. loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway. PMID: 25592291
  28. Inhibition of Erbb2 suppressed the increase in metalloproteinase ADAM12 expression in skin tumors. PMID: 24798404
  29. Data show that Muc4 is upregulated and interacts with erbB2 in gallbladders from BK5.erbB2 mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 signaling. PMID: 25174601
  30. ERBB2 is both necessary for cardiac myocyte proliferation and sufficient to reactivate postnatal CM proliferative and regenerative potentials. PMID: 25848746
  31. These findings suggest cooperative roles for bile acid and erbB2 activation in epithelial cell proliferation; bile acid appears to accelerate erbB2-induced pro-tumorigenic activities in the biliary tract and skin. PMID: 24839254
  32. A novel function of Erbb2 during atrial conduction system development. PMID: 25269082
  33. Data demonstrate that the E2F transcription factors are integral to HER2+ tumor development and progression. PMID: 24362522
  34. Results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway PMID: 24252174
  35. ERBB2-positive breast cancers are partially autophagy-deficient even in a wild-type BECN1 background PMID: 24492513
  36. The nuclear ErbB-2 and Stat3 are key players in progestin-induced p21(CIP1) regulation. PMID: 23178160
  37. In the HER2 mouse model, ErbB2 inhibition delays cancer progression, which is associated with HSF1 inactivation and destabilization of HSP90 targets. PMID: 24384723
  38. Wnt pathway-active cell subset in the normal mammary epithelium does not evolve into tumors following ErbB2 activation PMID: 24265712
  39. These results suggest that H. pylori CagA may induce overexpression of the HER-2 protein by increasing HER-2 DNA and mRNA copy number PMID: 24879917
  40. CREB plays an important role in the HER-2/neu-mediated transformation by altering in vitro and in vivo growth characteristics. PMID: 24025972
  41. A novel time-window is identified for embryonic stem cell cardiomyogenesis via Erbb2. PMID: 24364879
  42. Her-2 and beta-catenin appeared co-localized at the cell surface during tumor development and progression. PMID: 23397229
  43. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis. PMID: 23318421
  44. Myocilin binds to ErbB2/ErbB3, activates these receptors, and affects the downstream PI3K-AKT signaling pathway PMID: 23897819
  45. PIK3CA(H1047R) accelerates HER2-mediated breast epithelial transformation and metastatic progression, alters the intrinsic phenotype of HER2-overexpressing cancers, and generates resistance to approved combinations of anti-HER2 therapies PMID: 23940356
  46. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells. PMID: 23447672
  47. the acquired substrate preference for GAB1 is critical for the ERBB2 mutant-induced oncogenesis. PMID: 23612964
  48. HIF is a major downstream regulator of ERBB2 that protects cells from anoikis and metabolic stress caused by decreased matrix adhesion. PMID: 23585570
  49. HTT protein accelerates breast tumour development and metastasis through ErbB2 signalling. PMID: 23300147
  50. DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis. PMID: 23592719
  51. powerful inhibitory effect conferred by HSF1 downstream target genes in the inhibition of ErbB2-induced breast cancers in the absence of the Hsf1 gene. PMID: 22847003
  52. analysis of multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor PMID: 22737248
  53. c-erbB2 is closely correlated with fertilization. Ca2+ may inhibit fertilization by regulating expression of c-erbB2 gene in sperm cells. PMID: 21207860
  54. the up-regulation of the Pcdhbeta gene cluster as a mechanism for reduced her-2-mediated tumorigenesis resulting from GnT-V deletion. PMID: 22665489
  55. compartmental ligands-receptor model, describing binding kinetics, was used to evaluate HER2 expression from the time sequence of the fluorescence images after the intravenous probe injection PMID: 22554482
  56. Investigated whether a B-class CpG ODN (BW006), a TLR9 agonist, could facilitate HSP65-Her2, a recombinant protein between mycobacterial HSP65 and Her2-derived peptide, to induce vigorous anti-tumor activity against Her2 positive tumors PMID: 22222115
  57. Results expand the knowledge of ERBB2 tumorigenesis and point to a combined control of specific tumor phenotypes by germ-line polymorphisms and somatic alterations. PMID: 22419448
  58. Over-expression of COX-2 in mone oil-treated gall bladder cells may lead to up-regulation of its downstream signaling molecules via ErbB2 phosphorylation. PMID: 22411700
  59. ErbB2 and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells PMID: 22393391
  60. Metastasis of ErbB-2-dependent murine mammary cancers in vivo required Plexin B1. Overexpression of ErbB-2 stimulated Rho signaling & lung metastasis. PMID: 22378040
  61. HER2 targeting using anti-Treml4 mAbs elicited combined CD4(+) and CD8(+) T cell immunity PMID: 22210914
  62. The findings uncovered an unexpected link between PGC-1a-mediated nutrient availability, unfolded protein response, and ErbB2/Neu levels. PMID: 22266114
  63. has important cytoprotective and reparative roles in the colonic epithelium following injury PMID: 22157714
  64. Our work suggests that ErbB2-induced mammary tumorigenesis is independent of the normal variation in circulating levels of IGF-I. PMID: 21867536
  65. This study demonstrates that Her2-positive mammary cancers have redundant signals to sustain their proliferation and shows that statins simultaneously reduce the pro-proliferative Ras/ERK1/2 axis and activate the RhoA/RhoA-kinase/NF-kappaB axis. PMID: 21803026
  66. the Delta16HER2 splice variant represents the transforming form of the HER2 oncoprotein PMID: 21559085
  67. data suggest that stratification of CaP patients for HER2/3 and PTEN status could identify patients with aggressive CaP who may respond favorably to MEK inhibition PMID: 21930937
  68. Integrin beta4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF PMID: 21556948
  69. Data show that (99m)Tc-labeled 2Rs15d has a high tumor uptake in HER2(+) tumor models. PMID: 21478264
  70. Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways PMID: 21297664
  71. Results point to the potential therapeutic importance of simultaneous targeting of Igf1r and Her2 to abrogate resistance. PMID: 21447712
  72. the HER pathway is blocked by lapatinib and trastuzumab in HER2/neu-overexpressing breast tumor xenografts PMID: 21138857
  73. the ADAM17-NRG-1-HER2 axis modulates the alveolar epithelial barrier and contributes to the pathophysiology of ALI. PMID: 21247898
  74. Hunk is required for HER2/neu-induced mammary tumorigenesis PMID: 21393859
  75. ErbB2 is a natural signaling component that is required for oligodendrocyte precursor cells (OPC) proliferation, whereas ErbB2 inhibition or genetic knockdown results in OPC differentiation. PMID: 20544820
  76. Neu/V664E TM domain does not affect the phosphorylation levels of full-length FGFR3/A3 PMID: 20713021
  77. Used a SILAC-based approach to compare the proteomic profile of normal breast epithelial cells with that of Her2/neu-overexpressing mammary epithelial cells. PMID: 20960451
  78. Somatic expression of activated ErbB2 induces estrogen-independent ammary tumorigenesis. PMID: 20824048
  79. identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear translocation and the assembly of a transcriptional complex in which ErbB-2 acts as a coactivator of Stat3 PMID: 20876300
  80. Findings suggest that, although beta1-integrin is dispensable for the initiation of ErbB2 tumor induction, it plays a critical role in metastatic phase of tumor progression. PMID: 20713705
  81. TNFalpha is able to transactivate ErbB-2 and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals. PMID: 19760502
  82. the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways PMID: 20304052
  83. prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth PMID: 20498373
  84. data demonstrate that aberrant Notch regulation is an early event in mammary carcinogenesis and is associated with the HER-2 molecular subtype of breast cancer PMID: 20459529
  85. ILK has a critical role in the initiation phase of ErbB2 tumor induction. PMID: 20305688
  86. several functional units are coregulated by HER2/NEU PMID: 19960538
  87. Our data encourage further exploitation of HER-2(9(828)) as a promising candidate for peptide-based cancer vaccines PMID: 19904532
  88. Inhibition of PI3K and mTOR are required for the growth-inhibitory effect of HER2 antagonists PMID: 19934303
  89. Results show that coexpression of IL-15 and IL-15Ralpha in an anticancer vaccine enhanced immune responses against the NEU antigen and may overcome impaired CD4(+) T-helper function. PMID: 20086176
  90. Conclude that EGF and its related growth factors are important for maintaining transepithelial Na(+) transport and that EGF biphasically modulates sodium transport in cortical collecting duct cells via the ErbB2 receptor. PMID: 20049896
  91. data suggest that Stat3 might be a useful therapeutic target in breast tumors showing amplification and/or overexpression of the ErbB-2 oncogene, which normally display aggressive, metastatic behavior PMID: 20027636
  92. HER-2/neu transgenic mice possess tumor killing ability and underline the capacity of antitumor strategies designed to stimulate infiltrating myeloid cells. PMID: 19653277
  93. conditional expression of activated HER2/neu gene under its endogenous promoter in the mammary epithelium of the mouse resluts in accelerated lobular development and focal mammary tumors. PMID: 11840334
  94. ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas. PMID: 11950845
  95. ErbB2 is required for muscle spindle and myoblast cell survival (receptor ERBB-2) PMID: 12052879
  96. mutation leads to dilated cardiomyopathy PMID: 12072561
  97. data provide a link between extracellular matrix-hyaluronan and ErbB receptor activation during development of early heart-valve and septal mesenchyme PMID: 12134143
  98. Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway. PMID: 12140765
  99. ErbB2 signaling in the colonic epithelia is required for the postnatal survival of enteric neurons and glia. PMID: 12526770
  100. RPTPepsilon is a physiological activator of Src in Neu-induced mammary tumors. PMID: 12598528

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Subcellular Location Cell membrane, Single-pass type I membrane protein, Cytoplasm, perinuclear region, Nucleus
Protein Families Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.
Database Links

KEGG: mmu:13866

STRING: 10090.ENSMUSP00000053897

UniGene: Mm.290822

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