||Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
||Cell membrane, Single-pass type I membrane protein, Cytoplasm, perinuclear region, Nucleus
||Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
||Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.
Calcium signaling pathway
ErbB signaling pathway
HIF-1 signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway
Excitatory synapse pathway