Recombinant Mouse Receptor tyrosine-protein kinase erbB-2(Erbb2),partial

Product Type Recombinant Protein
Uniprot No. P70424
Species Mus musculus (Mouse)
Gene Names Erbb2
Protein Names Recommended name: Receptor tyrosine-protein kinase erbB-2 EC= 2.7.10.1 Alternative name(s): Proto-oncogene Neu Proto-oncogene c-ErbB-2 p185erbB2 CD_antigen= CD340
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Subcellular Location Cell membrane, Single-pass type I membrane protein, Cytoplasm, perinuclear region, Nucleus
Protein Families Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.
Database Links

KEGG: mmu:13866

STRING: 10090.ENSMUSP00000053897

UniGene: Mm.290822

Pathway Calcium signaling pathway
ErbB signaling pathway
HIF-1 signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Adherens junction
Excitatory synapse pathway

Product Details for Different Expression Systems

Product Name Recombinant Mouse Receptor tyrosine-protein kinase erbB-2(Erbb2),partial,Yeast
Code CSB-YP007763MO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Mouse Receptor tyrosine-protein kinase erbB-2(Erbb2),partial,E.coli
Code CSB-EP007763MO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Mouse Receptor tyrosine-protein kinase erbB-2(Erbb2),partial,Baculovirus
Code CSB-BP007763MO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Mouse Receptor tyrosine-protein kinase erbB-2(Erbb2),partial,Mammalian cell
Code CSB-MP007763MO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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