Recombinant Mouse Retinoic acid receptor RXR-alpha (Rxra)

1. Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease PMID: 28205585
2. Loss of RXRA is associated with Non-Small Cell Lung Cancer. PMID: 28923935
3. Mice lacking the RXR-alpha receptor develop spontaneous melanoma following a single ultraviolet radiation exposure compared to mice with functional RXR-alpha receptor. PMID: 29121869
4. The primary aim of the present study was to investigate the potential of Nur77 in Amyloid betainduced neuron apoptosis, and to evaluate the effect of RXRalpha nuclear export inhibition on neuronal apoptosis. PMID: 28627642
5. These data suggest that RXRs may be of crucial importance in the mechanism of allergic asthma and that the novel RXR partial agonist NEt-4IB may be a promising candidate for the treatment of allergic airway inflammation and airway hyperresponsiveness in a model of allergic asthma. PMID: 28114934
6. The study shows that FXR/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder. PMID: 28895119
7. These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration. PMID: 27051978
8. interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma PMID: 25738607
9. This uncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that downregulation of RXR expression or RXR antagonist treatment benefits host antiviral response, whereas RXR agonist treatment may increase risk of viral infections. PMID: 25417649
10. The expression and binding of RXRalpha to CYP3A genes in liver was sex-dependent and regulated by growth hormone secretion. PMID: 25451687
11. The depletion of retinoic acid and the inhibition of RXRalpha function in hepatic tumors involve more complex mechanisms besides the activation of RAS/ERK pathway. PMID: 25218146
12. These observations suggest that beta-apo-13-carotenone regulates RXRalpha transcriptional activity by inducing the formation of the "transcriptionally silent" RXRalpha tetramer. PMID: 25324544
13. RXRs modulate post-UVR survival of dermal fibroblasts in a "non-cell autonomous" manner, underscoring their role in immune surveillance, while independently mediating post-UVR melanocyte survival in a "cell autonomous" manner PMID: 24810760
14. Drupanin, a component of BGP, is a novel RXR agonist with slight PPARgamma agonistic activity. PMID: 24972164
15. two models of cholestasis identify common and injury-specific roles for RXRalpha heterodimers and the functional relevance of an intact RXRalpha-DNA-binding domain in the hepatocytic adaptive cholestatic response PMID: 24120911
16. This demonstrates the importance of RXRalpha in regulating inflammation in acute colitis and also identifies RXRalpha expression as a new consideration when developing treatment for acute colitis. PMID: 24146318
17. RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone. PMID: 23896434
18. RXRalpha appears to be one of the most widely distributed transcriptional regulators in mouse liver and is engaged in determining sexually-dimorphic expression of key lipid-processing genes. PMID: 23977068
19. These results illustrate a broadly applicable strategy for understanding the host response to infection in vivo and identify Rxra as the hub of a gene network controlling antileishmanial resistance. PMID: 24034621
20. MiR-128-2 inhibits the expression of ABCA1, ABCG1 and RXRalpha directly through a miR-128-2-binding site within their respective 3'untranslated regions. PMID: 23990020
21. Downregulation of retinoid X receptor alpha is associated with colitis-associated cancer. PMID: 23585425
22. Downregulation of RXRalpha, a nuclear receptor that can suppress NF-kappaB activity, mediates the elevation of COX2 expression and PGE2 production in senescent macrophages. PMID: 24051096
23. RXRalpha dictates the expression of genes that regulate RNA processing, translation, and protein folding illustrating the novel roles of hepatic RXRalpha in post-transcriptional regulation. PMID: 23166811
24. The expression of dominant-negative RAR (dnRAR) in the forebrain down-regulated the expression of RARbeta, a target gene of RAR/RXR, indicating that dnRAR mice exhibit dysfunction of the RAR/RXR signaling pathway. PMID: 22316320
25. High-grade prostate intraepithelial neoplasia develops in 79% of RXRalpha prostate null mice fed a new western diet containing high fat and low fiber). PMID: 22314496
26. There are differential regulatory roles for hepatic RXRalpha, both in basal and inflammatory states, suggesting new and complex multidomain roles for RXRalpha in regulating hepatic gene expression. PMID: 22098603
27. Studies indicate the cooperative effect between HPV16E6E7 expression and the lack of RXRalpha in cervical cancer development. PMID: 22138104
28. Using the light-induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis. PMID: 21940995
29. RXRalpha regulates mouse keratinocyte and melanocyte homeostasis following acute ultraviolet ray exposure PMID: 20944655
30. Data show that in the absence of keratinocytic RXRalpha, in combination with mutant Cdk4, cutaneous melanoma was generated that metastasized to lymph nodes in a bigenic mouse model. PMID: 20629968
31. The heart phenotypes of Rxra mutants are very similar and are characterized by a prominent defect in ventricular compact zone growth. PMID: 21138976
32. Modulation of endogenous RXRalpha in beta-cells may be a new therapeutic approach for improving impaired insulin secretion in type 2 diabetes. PMID: 20798333
33. analysis of the VDR/RXR cistrome in osteoblast and insight into the actions of the vitamin D hormone PMID: 20171278
34. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID: 20498053
35. Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers. PMID: 20035057
36. Effects of retinoic acid receptor beta (RARbeta) and retinoid X receptor alpha (RXRalpha) on the regulation of the alpha(2)(I) collagen promoter. PMID: 12054477
37. in response to retinoic acid and in a manner requiring the activity of RXRalpha, secretes trophic factors which drive fetal cardiomyocyte proliferation and promote ventricular chamber morphogenesis PMID: 12297106
38. role in coenzyme Q metabolism PMID: 12581641
39. testosterone has a negative impact on retinoid signaling when the level of RXRalpha is low, which may in turn reduce the expression of the CYP450 genes. PMID: 12746291
40. loss or reduction of RXRalpha activity is associated with prostate tumorigenesis PMID: 12750559
41. Data report the separation of RXR homo- and heterodimerization as an essential step towards the elucidation of the roles of RXR homo- and heterodimers in retinoid-rexinoid signaling. PMID: 14560013
42. results reveal molecular and structural features that impact on the ligand-dependent interaction of the RAR/RXR heterodimer with nuclear receptor coactivators PMID: 15528208
43. liver X receptors/RXR alpha agonists may be exploited to enhance innate immunity to bacterial pathogens that induce apoptotic programs as a strategy for evading host responses PMID: 15601766
44. Retinoic acid modulates the expression of RXRalpha in brown adipose tissue, suggesting auto regulation of the retinoid effect on the thermogenic system. PMID: 15646024
45. VDR and RXR have roles in 1,25(OH)2D3-induced transactivation in intact osteoblasts PMID: 15647825
46. the retinoid X receptor alpha knockout (RXRalpha-/-) embryo displays a malformed epicardium PMID: 15861408
47. in adipocytes RXRalpha is essential for lipogenesis PMID: 15936932
48. role of RXRalpha in phase II enzyme-mediated detoxification of acetaminophen PMID: 16157696
49. Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. PMID: 16199515
50. RXR alpha plays an important post-developmental role in the regulation of adaptive immune responses, and provides a plausible link between nutritional environment and the type of adaptive response that results from immunization. PMID: 16259011

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KEGG: mmu:20181

STRING: 10090.ENSMUSP00000076491

UniGene: Mm.24624