Recombinant Mouse Rho-associated protein kinase 2 (Rock2), partial

1. that platelet ROCK2 plays important role in platelet function and thrombosis, but does not contribute to the pathogenesis of atherosclerosis and vascular remodeling PMID: 28430966
2. This study showed that , APC/C(Cdh1)-mediated degradation of Rock2 maintains the dendritic network, memory formation, and neuronal survival, suggesting that pharmacological inhibition of aberrantly accumulated Rock2 may be a suitable therapeutic strategy against neurodegeneration. PMID: 28396402
3. data suggest that activation of ROCK2 in adipose tissue contributes to obesity-induced insulin resistance; this may result in part from suppression of PPARgamma expression, leading to adipocyte hypertrophy and an increase in inflammatory cytokine production; ROCK2 may be a suitable target to improve insulin sensitivity in obesity PMID: 27163743
4. ROCK2 contributes to allergic airways responses likely via effects within ASM cells and within non-lymphocyte cells involved in lymphocyte activation and migration into the airways. PMID: 27886408
5. BRAF and ROKalpha form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF). PMID: 28270557
6. these data suggest that ROCK2 signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 and STAT5 activation. PMID: 27436361
7. Results strongly support the hypothesis that spinal RhoA/ROCK2 signaling plays a central role in the neuropathic pain. In addition, simvastatin might exert its antihyperalgesic and antiallodynic effects through the attenuation of sensitization of spinal nociceptive transmission that is modulated by mechanisms dependent on the RhoA/ROCK2 signaling. PMID: 27457035
8. p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2/NF-kappaB signalling in skin carcinogenesis.these data show that ROCK2 activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 loss and novel NF-kappaB expression PMID: 27991921
9. The effect of Smad4 was at least partially mediated by the downstream effectors Syk and ROCK2 transcription in megakaryocytes. PMID: 28663280
10. Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues PMID: 27775859
11. The results of the present study verify that ROCKII participates in the loss of DA neurons induced by MPTP and suggest that ROCKII inhibition may be a promising therapeutic target for PD. PMID: 27840922
12. These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf gene expression is regulated by CTGF and ROCK2. PMID: 26825658
13. found that cigarette smoke leads to decreased ROCK2 activation and IRF4 phosphorylation in T cells PMID: 26882474
14. ROCK2 is pivotal to baseline junctional tension as a novel mechanism by which Rho kinase primes the endothelium for hyperpermeability responses. PMID: 25869521
15. increased activation of ROCK2 contributes to obesity-induced cardiac dysfunction and insulin resistance and that inhibition of ROCK2 may constitute a novel approach to treat this condition. PMID: 25910808
16. Ischemia/reperfusion injury activates ROCK2, preventing axonal growth. ROCK inhibitor, fasudil hydrochloride, promotes axonal growth. PMID: 25337198
17. Noise-decreased levels of ROCK2 results in reduction of phosphorylation of ERM that leads to depolymerization of actin filaments. PMID: 25683353
18. In cisplatin nephrotoxicity, Rho-kinase signaling affects the activation of T cells, which mediate acute kidney injury. PMID: 25651561
19. ROCK-2 regulates directional myoblast migration through focal adhesion formation and maturation. PMID: 24700588
20. ROCK 2, p38 MAPK and arginase play key roles in diabetes-induced impairment of corpora cavernosa relaxation. PMID: 23566117
21. ROCK2 in vascular smooth cells contributes to the pathogenesis of hypoxia-induced pulmonary arterial hypertension. PMID: 24135024
22. ROCK2(-/-) MEFs exhibited impaired focal adhesions but preserved adherens junctions compared with the wild-type MEFs. PMID: 23598717
23. Rock2 displays specific control of endothelial cell survival. PMID: 22934846
24. Rho kinase activity regulates sepsis-induced systemic inflammation. PMID: 23630965
25. ROCK2 is essential for the development of cardiac hypertrophy and that up-regulation of FHL2 may contribute to the antihypertrophic phenotype that is observed in cardiac-specific ROCK2-deficient mice. PMID: 23271052
26. ROCK2 is required for stabilizing actin cytoskeleton through regulating cofilin phosphorylation. PMID: 23392171
27. ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha. PMID: 23172836
28. ROCK2 contributes to atherosclerosis, in part, by inhibiting peroxisome proliferator-activated receptor-gamma-mediated reverse cholesterol transport in macrophages, which contributes to foam cell formation. PMID: 23011471
29. increased ROCK2 levels and enhanced ROCK activity are responsible for mustard oil-induced vascular hyperpermeability in arsenic-fed mice PMID: 21703283
30. A novel role has been uncovered for ROCK2 in amelogenesis. PMID: 21792909
31. provide direct evidence for the activation of ROCK II as a primary and sufficient downstream event of CDK2-cyclin E for the initiation of centrosome duplication and for the induction of centrosome amplification PMID: 21242972
32. These results indicate that the RhoA/Rho-kinase signaling pathway plays an essential role in the axon patterning of cranial somatic motor neurons during development. PMID: 21219475
33. in phosphorylated form participates in regulation of focal adhesion PMID: 20826462
34. ROCK2 is a key regulator in tracheal occlusion induced accelerated lung development. PMID: 20648664
35. Here, we investigated which Rho isoform(s) are involved in the activation of ROCK II in respect to the initiation of centrosome duplication. PMID: 20697357
36. NOD T4 cells aberrantly activate ROCK2. ROCK2 inhibition by fasudil corrects the abnormal IRF4 function in NOD T4 cells, diminishes their production of IL-17 and IL-21, and protects against type 1 diabetes development. PMID: 21111405
37. both Type 1 and Type 2 models of diabetes activation of the rhoA/rho kinase pathway may be increased in arteries from diabetic males despite no change in protein expression. PMID: 20368772
38. D2R-induced vulnerability in Huntington disease is critically linked to the activation of the Rho/ROCK signalling pathway. PMID: 20016831
39. ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death. PMID: 12832488
40. Comparison of cell migration, actin cytoskeleton activity, and signal pathways implies that B-Raf is involved in cell invasiveness by regulating the proper assembly of actin stress fibers and contractility through a ROCKII/LIMK/cofilin signaling pathway PMID: 15199148
41. p27 is important modulator of angiotensin II-induced monocyte/macrophage infiltration and vascular remodeling, mediated in part by Rho-kinase stimulation. Inhibition of Rho-kinase improves angiotensin II-induced vascular injury. PMID: 15699465
42. Fas activation stimulates the formation of Raf-1-Rok-alpha complexes, and Rok-alpha signaling is up-regulated in Raf-1-deficient cells. This leads to increased clustering and membrane expression of Fas PMID: 16365167
43. Stem cell mobilization in response to sphingosine-1-phosphate requires cooperation between matrix metalloproteinases, RhoA, Rho Kinase and Mitogen Activated Protein Kinase pathways. PMID: 16931773
44. H-ras negatively regulates basal tone in the IAS by inhibiting RhoA/Rho-kinase machinery. PMID: 17408635
45. increased contractions to serotonin in aorta from male mice are attributable to differences in RhoA/Rho-kinase activation in smooth muscle independent of differences in the expression of RhoA or Rho-kinase PMID: 17556652
46. Results identify a novel and evolutionarily conserved ROCK2 splicing variant, ROCK2m, that is preferentially expressed in skeletal muscle and strongly up-regulated during in vivo and in vitro differentiation processes. PMID: 17606625
47. ROCK-II is a critical mediator of colon cancer cell invasion through its modulation of MMP-2 and -13 at the site of invadopodia but regulates proliferation in non-malignant intestinal cells. PMID: 17876296
48. c-jun gene deletion reduced c-Src expression, hyperactivated ROCK II signaling, and reduced cellular polarity, migration, and invasiveness. PMID: 18216279
49. The aim of this study was to identify the G protein and signaling pathway involved in PAR(1)-mediated CCL2 production and release. PMID: 18353977
50. Rho-kinase may play an important role in murine airway hyperresponsivenes, and the bronchodilating action of Rho-kinase inhibition may offer a new therapeutic perspective in obstructive airway disease. PMID: 18434112

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KEGG: mmu:19878

STRING: 10090.ENSMUSP00000020904

UniGene: Mm.276024