Recombinant Mouse SET and MYND domain-containing protein 1 (Smyd1)

1. These findings provide functional evidence for a role of Smyd1, or any member of the Smyd family, in regulating cardiac energetics in the adult heart, which is mediated, at least in part, via modulating PGC-1alpha. PMID: 30061404
2. Smyd1 is responsible for restricting growth in the adult heart, with its absence leading to cellular hypertrophy, organ remodeling, and fulminate heart failure. Molecular studies reveal Smyd1 to be a muscle-specific regulator of gene expression and indicate that Smyd1 modulates expression of gene isoforms whose expression is associated with cardiac pathology. Activation of Smyd1 can prevent pathological cell growth. PMID: 27663768
3. This work illustrates a crucial role for SMYD1 in skeletal muscle physiology and myofibril integrity. PMID: 26935107
4. Deletion of Smyd1 impaired myoblast differentiation, resulted in fewer myofibers and decreased expression of muscle-specific genes PMID: 26688546
5. Smyd1 is required for maintaining cardiomyocyte proliferation at minimally two different embryonic heart developmental stages PMID: 25803368
6. suggest for the first time that, in addition to being a master redox regulator of protein disulfide bonds and nitrosation, Trx1 may also modulate lysine methylation, a non-redox post-translational modification, via the regulation of SMYD1 expression PMID: 26410624
7. the skNAC-Smyd1 complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation. PMID: 26162853
8. skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 and that knockdown of Nse2 expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 complex PMID: 25002400
9. MYND domain may primarily serve as a protein interaction module and cooperate SmyD1 with skNAC to regulate cardiomyocyte growth and maturation. PMID: 20943667
10. The muscle-specific transcription factor skNAC is the major binding partner for Smyd1 in the developing heart. PMID: 21071677
11. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. PMID: 11923873
12. Similar kinetics of induction and localization of m-Bop and skNAC during the induction of myogenesis in cultured C2C12 cells suggests a possible associated role for these proteins during this process. PMID: 12011100
13. effects of gene mutations on ventricular development PMID: 12858532
14. BOP, a regulator of right ventricular heart development, is an essential downstream effector gene of MEF2C in the developing heart. PMID: 15890826
15. SmyD1a and SmyD1b are histone methyltransferases that play a critical role in myofibril organization during myofiber maturation. PMID: 16477022
16. HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP. PMID: 19162039

Show More

Hide All

KEGG: mmu:12180

STRING: 10090.ENSMUSP00000073911

UniGene: Mm.234274