Recombinant Mouse Serine/threonine-protein kinase ICK (Ick)

Code CSB-YP881339MO
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Source Yeast
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Code CSB-EP881339MO
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Source E.coli
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Code CSB-EP881339MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP881339MO
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Source Baculovirus
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Code CSB-MP881339MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Ick
Uniprot No.
Alternative Names
Cilk1; IckSerine/threonine-protein kinase ICK; EC 2.7.11.1; Intestinal cell kinase; mICK; MAK-related kinase; MRK
Species
Mus musculus (Mouse)
Expression Region
1-629
Target Protein Sequence
MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP IDIWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFLWPQ CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GIISKDSGKP QREVQDKTGP PPYIKPAPPA QAPAKAYTLI SSRPSQASQP PQHSVHPYKG DVSRTEQLSH VQEGKPSPPF FPSLHNKNLQ PKILASLEQK NGEIKPKSRR RWGLISRSTK GSDDWADLDD LDFSPSLTRI DVKNKKRQSD DTLCRFESVL DLKPSESVGT GTTVSTQASS QRRDTPTLQS SAKQHYLKHS RYLPGINIRN GVLPNPGKDF LPSNSWSSSG LSGKSSGTVS VVSKITSVGS GSASSSGLTG SYIPSFLKKE IGSVMQRVQL APLAAPPPGY SSLKAVRPHP GRPFFHTQPR STPGLIPRPP AAQPVHGRID WSSKYPSRR
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a role in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity.
Gene References into Functions
  1. These results suggest that Ick is expressed in proliferating regions in the adult mouse brain, testis, and intestine. PMID: 29635032
  2. Data indicate an essential role for intestinal cell kinase (ICK) in lung development and advances the mechanistic understanding of endocrine-cerebro-osteodysplasia (ECO) syndrome. PMID: 28380258
  3. The results of this study found that loss of Ick leads to abnormal localization of the IFT component in kinocilia, PCP defects in HCs, and hearing dysfunction. PMID: 28115485
  4. findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
  5. ICK is a Kif3a kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia. PMID: 24797473
  6. ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822

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Subcellular Location
Cytoplasm, cytosol. Cell projection, cilium. Nucleus. Cytoplasm, cytoskeleton, cilium basal body.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Tissue Specificity
Highly expressed in colon and lung, lower levels present in heart, esophagus, stomach, small intestine and ovary. Localizes to the crypt region of large and small intestine.
Database Links
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