Recombinant Mouse Serine/threonine-protein kinase Sgk1 (Sgk1)

1. SGK1 influences migration of VSMC by transcriptional regulation of Ca2+ channel Orai1 expression, an effect requiring SGK1-dependent activation of transcription factor NF-B after arterial injury. PMID: 28203685
2. results suggest that SGK1 may play a critical role in the inflammatory cascade of cardiac fibroblasts triggered by mechanical stretch; SGK1 could be used as a potential target for treatment of cardiac fibrosis and heart failure PMID: 29243066
3. Decreased expression of SGK1 may play a critical role in increasing the expression of alpha-syn, which is related with dopaminergic cell death in the Substantia nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. PMID: 29604467
4. High SGK1 expression is associated with anxiety/depression. PMID: 27502757
5. Experiments showed a dynamic change of immune inflammation, oxidative stress and p38MAPK-SGK1 pathway involvement in EAE demonstrating that p38MAPK-SGK1 pathway and oxidative stress contribute to the demyelination in central nerve system caused by Th17 inflammatory responses in a synergistic way. PMID: 28467798
6. SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations. PMID: 29055016
7. Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression. PMID: 28504714
8. Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion PMID: 27413200
9. our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2, WNK1, and ENaC PMID: 27009335
10. SGK1 is similarly involved in the regulation of cell volume and cell fluid transport. PMID: 27861175
11. Mineralocorticoid receptor deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1/NF-kappaB pathways. PMID: 26966277
12. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway. PMID: 28389565
13. SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses. PMID: 27457803
14. The data indicate that the balanced activities of two related serine/threonine kinases, AKT and SGK1, critically govern the embryo implantation process. PMID: 27825168
15. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
16. high levels of resistin observed during obesity may activate SGK1 in the vasculature and contribute to the development of obesity-related vascular disease PMID: 26833885
17. High salt diet may deteriorate lupus nephritis through SGK1 pathway. PMID: 26474695
18. Study shows that SGK1 impairs nuclear abundance of p27 and suggests that phosphorylation of p27T197 by SGK1 is required for cardiac hypertrophy. PMID: 26344141
19. SGK1 appears to be an important enzyme in the process of fibrotic remodeling and subsequent weakness of dystrophin-deficient mouse muscle PMID: 25394886
20. The characterisation of SGK1 functions in obesity and immunity may help identify potential therapeutic targets in the treatment of obesity. PMID: 25809829
21. Identify SGK1 as a novel powerful regulator of platelet dense granule biogenesis, platelet secretion and thrombus formation. SGK1 is at least partially effective because it regulates transcription of Rab27b in megakaryocytes. PMID: 25944668
22. SGK1 plays a pivotal role in vascular inflammation during atherogenesis. SGK1 participates in the regulation of monocyte/macrophage migration and MMP-9 transcription via regulation of nuclear factor-kappaB. PMID: 25614279
23. SGK1 inhibits intestinal epithelial cell apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis. PMID: 26034353
24. measured gene expression of Fos, Per1 and Sgk1 45 min after exposure to brief cold swim stress in male and female mice; Sgk1 was insensitive to handling, and increased in response to stress similarly in males and females PMID: 25459888
25. 17beta-estradiol attenuates LPS-induced acute lung injury via PI3K/Akt/SGK1 mediated up-regulation of Scnn1a. PMID: 25551628
26. These findings have identified an anti-inflammatory function of SGK1, elucidated the underlying intracellular mechanisms PMID: 25993992
27. Sgk1 regulates Dsg1c expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure. PMID: 26043694
28. Macrophages that expressed SGK1 were able to promote pulmonary arterial smooth muscle cells proliferation, which was lost with SGK1-deficient mice. PMID: 24825325
29. SGK1 and NDRG1 participate in the regulation of NF-kappaB signaling in and maturation of DCs PMID: 25200670
30. SGK1 inhibits ERK1/2 (extracellular-signal-regulated kinase 1/2) activity in liver and Ad-shERK1/2-mediated inhibition of ERK1/2 reverses the attenuated insulin sensitivity in Ad-shSGK1 mice PMID: 25222560
31. Repeated, but not acute, morphine or cocaine administration increases SGK1 gene expression and activity in the ventral tegmental area. This increase may play a role in drug-dependent behaviors. PMID: 25099208
32. mTORC1, in coordination with mTORC2, controls cell proliferation by regulating FoxO3a gene expression and SGK1-mediated phosphorylation of FoxO3a at Ser314 PMID: 24558442
33. SGK-dependent phosphorylation of glycogen synthase kinase GSK-3 contributes to the pro-fibrotic signaling leading to renal tissue fibrosis in obstructive nephropathy PMID: 24685987
34. Pendrin is expressed in platelets and is presumably regulated by SGK1 and mineralocorticoids. PMID: 24429827
35. This study underscores the importance of SGK1 signalling in cardiac neo-angiogenesis and wound healing after an ischemic insult in vivo. PMID: 24265802
36. promotes T helper type 2 differentiation after activation by mTORC2 PMID: 24705297
37. adaptive molecular responses of glucocorticoid-responsive gene expression and SGK1 in prefrontal cortex may contribute to mechanisms underlying behavioral responses to chronic ethanol exposure PMID: 23991167
38. stress-induced Sgk-1 localizes to the mitochondria, which permits access to mitochondrial interacting proteins and substrates, such as IF-1 and the F1F0-ATPase PMID: 23402912
39. SGK1 has a critical role in the induction of pathogenic TH17 cells and provide a molecular insight into a mechanism by which an environmental factor such as a high salt diet triggers TH17 development and promotes tissue inflammation PMID: 23467085
40. Renally expressed Sgk1 isoform, Sgk1_i3, stimulates ENaC activity when heterologously expressed in collecting duct cells. PMID: 23034940
41. SGK1-dependent divalent calcium (Ca2+) ion-labelled entry into mast cells is a novel mechanism that regulates the cell actin cytoskeleton. PMID: 23015548
42. Cardiac-specific SGK1 activation increased mortality, cardiac dysfunction, & ventricular arrhythmias via sodium channels, but protected from fibrosis & heart failure after stress. SGK1 binds directly to Nav1.5. PMID: 23019294
43. SGK1 participates in the signaling of platelet migration PMID: 22759972
44. SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT. PMID: 22590650
45. SGK1 may play an important role in macrophage recruitment and M2 macrophage activation by activating the STAT3 pathway, which leads to angiotensin II-induced cardiac fibrosis. PMID: 22556335
46. The impaired ability of Sgk1 knockout mice to retain Na+ increased significantly with a low-salt diet despite higher plasma aldosterone levels. On a low-Na+ diet, the Sgk1 knockout mice were also hyperkaliuric and lost body weight. PMID: 22301619
47. According to the present observations, SGK1 is a major determinant of NHE1 activity in the failing heart. PMID: 22212557
48. Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage. PMID: 22001908
49. Data show that vitamin D treatment upregulates the expression of SGK1, which in turn enhances SGLT1 activity. PMID: 21735060
50. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. PMID: 21900244

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KEGG: mmu:20393

STRING: 10090.ENSMUSP00000114074

UniGene: Mm.28405