Recombinant Mouse Serine/threonine-protein kinase/endoribonuclease IRE1 (Ern1), partial

1. IRE1alpha has a critical role in colonic tumorigenesis and IRE1alpha targeting might be a strategy for treatment of colon cancers. PMID: 28825721
2. Study provided the first link between energy homeostasis, lipid metabolism and pro-opiomelanocortin (POMC) neuronal IRE1alpha function. The effects of POMC IRE1alpha knockout were mediated via increased thermogenesis, possibly caused by the increased alpha-MSH production in the hypothalamus. These results demonstrate that IRE1alpha in POMC neurons plays a critical role in the regulation of obesity and obesity-related m... PMID: 27558934
3. cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner. PMID: 27626662
4. Data suggest that activation of GRP78/Ire1/Xbp1 pathway of ER stress-unfolded protein response is involved in mouse decidualization. PMID: 27283502
5. Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels. PMID: 28550308
6. defective autophagy in intestinal epithelial cells (IECs) may predispose to Crohn's disease ileitis via impaired clearance of IRE1alpha aggregates during ER stress at this site. PMID: 28082357
7. The findings indicate that IRE1-XBP1 downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth. PMID: 28167662
8. the ABL family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis. PMID: 28380378
9. We reveal distinct binding affinities between the binary and ternary complexes thus formed, that suggest a preference for the PERK signaling branch under stress, and a predilection for the GRP78-UPR sensor complex formation upon stressor removal. These results imply a gated UPR mechanism that tunes the overall cellular behavior to the accumulation of unfolded proteins. PMID: 28416388
10. Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs. PMID: 27634225
11. Ire1alpha-Xbp1s and associated molecular targets link ER stress in arcuate Pomc neurons to aspects of normal energy and glucose homeostasis. PMID: 28028078
12. heat stress simultaneously activates both the unfolded protein response (UPR) and autophagy, followed by the activation of a negative feedback system in UPR by modulating the responses related to the IRE1alpha-XBP-1 axis. PMID: 27743894
13. this study shows that IRE1alpha is a critical switch governing M1-M2 macrophage polarization and energy balance in obesity PMID: 28346409
14. Findings indicate that PERK kinase-activating transcription factor 4 (ATF4) pathway affected the efficiency of X-box binding protein 1 (XBP1) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha) expression. PMID: 27052593
15. Palmitate increased TRB3 expression, activated IRE1alpha signaling, and reduced the insulin-dependent Akt phosphorylation. Knocking down TRB3 or IRE1alpha did not prevent the inhibitory effect of palmitate on Akt phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes. PMID: 26337904
16. PKA-dependent IRE1alpha-XBP1 activation is crucial for the transcriptional induction of Ucp1 in brown adipocytes. PMID: 26568450
17. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK. PMID: 26446798
18. SphK1 inhibited the IRE1alpha pathway by reducing IRE1alpha expression at the transcriptional level. PMID: 26240153
19. IRE1alpha may promote liver regeneration through acting as a signaling platform to regulate the STAT3 pathway. PMID: 25457211
20. The present study thus reveals an intracellular pathway that integrates the UPR and osteoclast differentiation through activation of the IRE1alpha/XBP1 pathway. PMID: 26193638
21. CReP expression was markedly suppressed in XBP1-deficient mice livers due to hyperactivated Ire1alpha. PMID: 26031337
22. results suggest that IRE1alpha functions to maintain the intestinal epithelial homeostasis and plays an important role in defending against inflammation bowel diseases PMID: 25925952
23. These results indicate that IRE1alpha can promote beta-cell proliferation through, at least in part, XBP1s upregulation of cyclin D1, which is known to drive cells from the G1 into the S-phase of the cell cycle. PMID: 24797433
24. these data describe a mechanism by which inflammatory pathways compromise unfolded protein response function through iNOS-mediated S-nitrosylation of IRE1alpha, which contributes to defective IRE1alpha activity, impaired ER function, and prolonged endoplasmic reticulum stress in obesity. PMID: 26228140
25. SEC63 deficiency selectively activates the IRE1alpha-XBP1 branch of the unfolded protein response. SEC63 function regulates IRE1alpha/XBP1 activation. PMID: 25844898
26. ER stress-mediated IRE1alpha activation is part of mutant Htt toxicity and that this is counteracted by Usp14 expression. PMID: 24951540
27. RIPK1 indirectly regulates caspase-8 activation, in part via interaction with the ER stress sensor IRE1. PMID: 25476903
28. Endoplasmic reticulum stress-induced IRE1alpha activation mediates cross-talk of GSK-3beta and XBP-1 to regulate inflammatory cytokine production. PMID: 25821218
29. IRE1alpha demonstrates prominent expression in proliferating and prehypertrophic chondrocytes in thewildtype embryonic growth plate, whereas its expression is hardly detectable in GEP-/- embryos. PMID: 24863879
30. The IRE1alpha-XBP1 pathway of the unfolded protein response could directly activate the transcriptional expression of Fgf21. PMID: 25170079
31. Data show that hepatic IRE1alpha protein promotes the adaptive shift of fuel utilization during starvation by stimulating mitochondrial beta-oxidation and ketogenesis through the X-box binding protein 1-Peroxisome proliferator-activated receptor alpha axis. PMID: 24670948
32. IRE1a, BMP2, GEP growth factor, and JunB transcription factor form a regulatory loop and act in concert in the course of osteoblastogenesis. PMID: 24853417
33. The transcriptional activity of activating transcription factor 6 (ATF6) remained unchanged after incubation with H2O2. PMID: 24915138
34. a precisely regulated feedback circuit involving IRE-1alpha and XBP-1 controls the homeostasis of CD8alpha+ conventional dendritic cells PMID: 24441789
35. IRE1 downregulation represents a previously undescribed viral strategy to curb the UPR. PMID: 23950715
36. IRE1alpha dissociates from BiP and inhibits ER stress-mediated apoptosis in the process of cartilage development. PMID: 23816533
37. This study identifies a regulatory function for IRE1alpha in the promotion of IL-4 in T cells. PMID: 24100031
38. A novel regulatory axis through TRAF6-mediated IRE1alpha ubiquitination indicates that IRE1alpha is a potential therapeutic target for inflammatory arthritis. PMID: 23942232
39. eIF2alpha and CHOP, but not IRE1alpha, have roles in ER stress signaling that attenuates adipogenesis in mice PMID: 23314846
40. Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1alpha degradation of netrin-1. PMID: 23473031
41. Disruption of IRE1alpha and XBP1 drastically attenuated the expression of Cts7 and Cts8, which are essential cathepsins for placenta formation. PMID: 23541586
42. The IRE1alpha-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in PTH-induced osteoclastogenesis. PMID: 23235147
43. An essential role for the inositol-requiring transmembrane kinase/endoribonuclease 1alpha (IRE1alpha)-X box binding protein 1 (XBP1) arm of the UPR is in regulation of hepatic very low-density lipoprotein (VLDL) assembly and secretion. PMID: 23040069
44. IRE1 alpha degrades mRNAs encoding lipid metabolism regulators. PMID: 23040070
45. IRE1-alpha activation and signaling require concerted coordination between the endoplasmic reticulum and cytoskeleton PMID: 23237951
46. IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. PMID: 22883233
47. IRE1alpha regulates translation of a proapoptotic protein, Caspase-2, through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response PMID: 23042294
48. The authors show that 1 alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, is required to maintain hepatic lipid homeostasis under ER stress conditions through repressing hepatic lipid accumulation and maintaining lipoprotein secretion. PMID: 21407177
49. The authors identified the BCL-2 family member PUMA as a novel IRE1alpha interactor. Immun oprecipitation experiments confirmed this interaction and further detected the association of IRE1alpha with BIM, another BH3-only protein. PMID: 22510886
50. IRE1alpha plays an essential role in the down-regulation of Cyp1a2 and Cyp2e1 mRNAs under endoplasmic reticulum stress. PMID: 22291093

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KEGG: mmu:78943

STRING: 10090.ENSMUSP00000001059

UniGene: Mm.340943