Recombinant Mouse Short stature homeobox protein 2(Shox2)

Code CSB-YP021277MO
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Source Yeast
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Code CSB-EP021277MO
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Source E.coli
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Code CSB-EP021277MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021277MO
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Source Baculovirus
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Code CSB-MP021277MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Shox2
Uniprot No. P70390
Alternative Names Shox2; Og12x; Prx3; Short stature homeobox protein 2; Homeobox protein Og12X; OG-12; Paired family homeodomain protein Prx3
Species Mus musculus (Mouse)
Expression Region 1-331
Target Protein Sequence MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP GCVEPGRDDR SSPAVRAAGG GGGAGGGGGG GGGGGGGAGG GGAGGGAGGG RSPVRELDMG AAERSREPGS PRLTEVSPEL KDRKDDAKGM EDEGQTKIKQ RRSRTNFTLE QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV AAAAAAKTTS KNSSIADLRL KAKKHAAALG L
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.
Gene References into Functions
  1. Shox2(+/+) and Shox2(-/-) embryonic stem cell clones were isolated and differentiated according to five different protocols in order to evaluate the most efficient enrichment of sinoatrial node-like cells. . PMID: 28390247
  2. Shox2 patterns the stylopod as a repressor via interaction with enhancers active in the proximal limb mesenchyme and antagonizes the repressive function of TALE factors in osteogenesis. PMID: 27287812
  3. This study shows that expressing human SHOX in Shox2SHOX KI/KI mice leads to congenital osteoarthritislike disease of the temporomandibular joint in postnatal mice. This provides a novel in vivo model for studying the molecular and cellular mechanisms of temporomandibular joint osteoarthritis. PMID: 27601064
  4. Electric-pulse current stimulation (EPCS) promotes the differentiation of mShox2 genetically modified canine mesenchymal stem cells (cMSCs) into pacemaker-like cells, which generates more If current. PMID: 26045052
  5. Results demonstrate that elimination of Shox2 in the brain results in disruptions in the development of the facial (VII) nerves and the facial motor nucleus PMID: 26156498
  6. the Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node PMID: 26138475
  7. Shox2 expression restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13. PMID: 25217052
  8. study suggested that a certain concentration of FA causes the bone marrow toxicity by regulating the expression of Prx3 PMID: 25673198
  9. Data indicate the importance of short stature homeobox 2 (Shox2) in the cerebellum. PMID: 25528224
  10. Shox2 regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad-dependent pathway to drive tissue growth and to induce Hcn4 expression PMID: 25488669
  11. phosphorylation essential for repression of Nkx2.5 expression during sinoatrial node development and differentiation PMID: 24847033
  12. These data extend our understanding of the role and regulation of Tbx4 and Shox2 in limb development and limb associated diseases. PMID: 24347445
  13. Although human SHOX can exert similar functions to mouse Shox2 in regulating early temporomandibular joint development, it apparently has a distinct function in the regulation of those molecules that are involved in tissue homeostasis. PMID: 24248941
  14. Shox2 regulates progression through chondrogenesis at two distinct stages--the onset of early differentiation and the transition to maturation and hypertrophy. PMID: 23038774
  15. both hSHOX and mShox2 limb enhancers are coupled to distinct neural enhancers. This is the first report demonstrating the activity of cis-regulatory elements from the hSHOX and mShox2 genomic regions in mammalian embryos. PMID: 23575226
  16. Optogenetic silencing or blocking synaptic output of Shox2 interneurons in transgenic mice perturbed rhythm without an effect on pattern generation PMID: 24267650
  17. Shox2 can regulate the expression of Adrb3 and control the rate of lipolysis and, in this way, exerts control of the phenotypic differences between visceral and s.c. adipocytes PMID: 23798383
  18. Our findings demonstrate a novel epistatic relationship between Shox2 and Isl1 in the heart with important developmental consequences for sinoatrial node formation and heart beat. PMID: 23455426
  19. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PMID: 22916278
  20. These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin. PMID: 22103411
  21. our findings identify Shox2 as an essential but not sufficient component of the transcription programs required in neural progenitor cells for the proper specification of subsets of TrkB-expressing touch/mechanosensory neurons. PMID: 21543603
  22. there is a functional redundancy between human SHOX and mouse Shox2 in the regulation of SAN formation and pacemaking function in addition to several other organs PMID: 21454626
  23. Shox2 is required for normal skeletal, neural and muscular development in the forelimb at a similar early developmental stage in each tissue. PMID: 21156168
  24. demonstrated an intrinsic requirement for Shox2 in palatogenesis PMID: 16141225
  25. Shox2 acts upstream the Runx2 gene, a key regulator of chondrogenesis. PMID: 16537395
  26. Shox2-/- embryos exhibited severe hypoplasia of the sinus venosus myocardium in the posterior heart field, including the sinoatrial nodal region and venous valves. PMID: 17372176
  27. Shox2 has a key role in regulating the growth of stylopod by controlling chondrocyte maturation via Runx2 and Runx3 PMID: 17481601
  28. Data show that mice carrying a conditional inactivation of Shox2 in the palatal mesenchyme survive the embryonic and neonatal lethality, but develop a wasting syndrome. PMID: 18393307
  29. Shox2 appears to regulate the expression of osteogenic genes and is essential for the development and function of the temporomandibular joint. PMID: 18514492
  30. Results demonstrate that Shox2 plays an essential role in the sinoatrial node and pacemaker development by controlling a genetic cascade through the repression of Nkx2-5. PMID: 19166829

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Subcellular Location Nucleus
Protein Families Paired homeobox family, Bicoid subfamily
Tissue Specificity Highly expressed in striated muscle followed by liver, kidney, testis, brain, heart, lung and spleen.
Database Links

KEGG: mmu:20429

STRING: 10090.ENSMUSP00000029422

UniGene: Mm.39093

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