Recombinant Mouse Short stature homeobox protein 2 (Shox2)

1. Shox2(+/+) and Shox2(-/-) embryonic stem cell clones were isolated and differentiated according to five different protocols in order to evaluate the most efficient enrichment of sinoatrial node-like cells. . PMID: 28390247
2. Shox2 patterns the stylopod as a repressor via interaction with enhancers active in the proximal limb mesenchyme and antagonizes the repressive function of TALE factors in osteogenesis. PMID: 27287812
3. This study shows that expressing human SHOX in Shox2SHOX KI/KI mice leads to congenital osteoarthritislike disease of the temporomandibular joint in postnatal mice. This provides a novel in vivo model for studying the molecular and cellular mechanisms of temporomandibular joint osteoarthritis. PMID: 27601064
4. Electric-pulse current stimulation (EPCS) promotes the differentiation of mShox2 genetically modified canine mesenchymal stem cells (cMSCs) into pacemaker-like cells, which generates more If current. PMID: 26045052
5. Results demonstrate that elimination of Shox2 in the brain results in disruptions in the development of the facial (VII) nerves and the facial motor nucleus PMID: 26156498
6. the Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node PMID: 26138475
7. Shox2 expression restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13. PMID: 25217052
8. study suggested that a certain concentration of FA causes the bone marrow toxicity by regulating the expression of Prx3 PMID: 25673198
9. Data indicate the importance of short stature homeobox 2 (Shox2) in the cerebellum. PMID: 25528224
10. Shox2 regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad-dependent pathway to drive tissue growth and to induce Hcn4 expression PMID: 25488669
11. phosphorylation essential for repression of Nkx2.5 expression during sinoatrial node development and differentiation PMID: 24847033
12. These data extend our understanding of the role and regulation of Tbx4 and Shox2 in limb development and limb associated diseases. PMID: 24347445
13. Although human SHOX can exert similar functions to mouse Shox2 in regulating early temporomandibular joint development, it apparently has a distinct function in the regulation of those molecules that are involved in tissue homeostasis. PMID: 24248941
14. Shox2 regulates progression through chondrogenesis at two distinct stages--the onset of early differentiation and the transition to maturation and hypertrophy. PMID: 23038774
15. both hSHOX and mShox2 limb enhancers are coupled to distinct neural enhancers. This is the first report demonstrating the activity of cis-regulatory elements from the hSHOX and mShox2 genomic regions in mammalian embryos. PMID: 23575226
16. Optogenetic silencing or blocking synaptic output of Shox2 interneurons in transgenic mice perturbed rhythm without an effect on pattern generation PMID: 24267650
17. Shox2 can regulate the expression of Adrb3 and control the rate of lipolysis and, in this way, exerts control of the phenotypic differences between visceral and s.c. adipocytes PMID: 23798383
18. Our findings demonstrate a novel epistatic relationship between Shox2 and Isl1 in the heart with important developmental consequences for sinoatrial node formation and heart beat. PMID: 23455426
19. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PMID: 22916278
20. These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin. PMID: 22103411
21. our findings identify Shox2 as an essential but not sufficient component of the transcription programs required in neural progenitor cells for the proper specification of subsets of TrkB-expressing touch/mechanosensory neurons. PMID: 21543603
22. there is a functional redundancy between human SHOX and mouse Shox2 in the regulation of SAN formation and pacemaking function in addition to several other organs PMID: 21454626
23. Shox2 is required for normal skeletal, neural and muscular development in the forelimb at a similar early developmental stage in each tissue. PMID: 21156168
24. demonstrated an intrinsic requirement for Shox2 in palatogenesis PMID: 16141225
25. Shox2 acts upstream the Runx2 gene, a key regulator of chondrogenesis. PMID: 16537395
26. Shox2-/- embryos exhibited severe hypoplasia of the sinus venosus myocardium in the posterior heart field, including the sinoatrial nodal region and venous valves. PMID: 17372176
27. Shox2 has a key role in regulating the growth of stylopod by controlling chondrocyte maturation via Runx2 and Runx3 PMID: 17481601
28. Data show that mice carrying a conditional inactivation of Shox2 in the palatal mesenchyme survive the embryonic and neonatal lethality, but develop a wasting syndrome. PMID: 18393307
29. Shox2 appears to regulate the expression of osteogenic genes and is essential for the development and function of the temporomandibular joint. PMID: 18514492
30. Results demonstrate that Shox2 plays an essential role in the sinoatrial node and pacemaker development by controlling a genetic cascade through the repression of Nkx2-5. PMID: 19166829

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KEGG: mmu:20429

STRING: 10090.ENSMUSP00000029422

UniGene: Mm.39093