Recombinant Mouse Sodium-dependent serotonin transporter (Slc6a4), partial

1. Slc6a4 mutations affect neuroanatomy in 5-HT relevant brain regions assessed by MRI. PMID: 29651330
2. Together, these findings support that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance, and suggest approaches to restore 17beta-estradiol levels as a novel treatment option for SERT deficiency associated obesity and metabolic abnormalities. PMID: 28442777
3. NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression. PMID: 29913461
4. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin-knockout pups. PMID: 29087295
5. Adrenal glands from wild-type mice contained 5-HT at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT receptors but were reduced in SERT(-/-) cells compared to wild-type cells. PMID: 27544824
6. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays. PMID: 27447971
7. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders PMID: 27282696
8. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment. PMID: 27550733
9. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT contributions of drug actions in vivo. PMID: 26514584
10. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice. PMID: 28629963
11. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD. PMID: 28323282
12. Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT. These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells. PMID: 27111230
13. This study showed that the decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter. PMID: 27125304
14. Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation PMID: 28033388
15. Data show that SERT associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier 1 family co-expressed with SERT in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane. PMID: 27143784
16. In mice, SERT expression was suppressed in inflamed mucosa and continuously observed with low-grade mucosal inflammation during colitis healing. PMID: 26676714
17. Results suggest a novel mechanism through which increased expression of the 5-HTT gene can alter the microcircuitry of the amygdala PMID: 26052039
18. miR-24 played a role in the pathogenesis of IBS probably through regulating SERT expression. PMID: 26631964
19. Results reveal dissimilarities in adult behavior and neurotransmission arising from developmental exposure to different widely prescribed antidepressants that are not recapitulated by genetic SERT insufficiency PMID: 25523893
20. Increased 5-HTT expression reduces negative cognitive bias for stimuli with uncertain outcomes. PMID: 25824641
21. Cohabitation with a female (mating experience) reduced anxiety-like behavior and increased exploratory locomotion in the open field test in male heterozygous 5-HTT knockout mice but did not affect wildtype mice PMID: 25629942
22. The serotonin transporter gene (5-HTT/SLC6A4)-linked polymorphic region (5-HTTLPR) is assumed to modulate the interaction between developmental stress exposure and emotional dysregulation later in life. PMID: 25335169
23. This study demonstrated that the cell signaling level, probably contributes to the moderation of the anxiety phenotype in 5-HTT(-/-) mice. PMID: 25522398
24. Results show that increased 5-HTT expression has some maladaptive effects on reinforcement learning, supporting recent suggestions that l allele homozygosity may be a potential risk factor for disabling psychiatric traits PMID: 25283165
25. The interaction between SERT and alphaCaMKII was confirmed in serotonergic neurons where they are colocalized. PMID: 26019340
26. In SERT-knockout mice there is increased stress sensitivity associated with enhanced capacity of 5-HT1A receptors. PMID: 25261781
27. in the presence of both Itgb3 and Slc6a4 heterozygozity, 5-HT uptake was similar to wild-type levels, revealing a significant Slc6a4 by Itgb3 genetic interaction PMID: 24083985
28. Direct experimental manipulation of 5-HTT expression levels throughout the brain markedly altered fear learning, amygdala hemodynamic responses, and neuronal oscillations. PMID: 24120093
29. Data indicate that subregion-specific decreases in hippocampal 5-HTT protein expression and function are associated with endophenotypes of depression PMID: 24436084
30. Reduced serotonin transporter in brain increases synaptic 5-HT concentration. PMID: 24646401
31. 5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze PMID: 24167611
32. The data of this study indicated that down-regulation of hippocampal 5-HTT protein expression is a signature change associated with anhedonia. PMID: 23558306
33. These results identify CaN as an important regulator of SERT activity in the adult brain PMID: 24107951
34. The findings corroborate that anxiety profiles in mice can be affected by both early environmental conditions and 5-HTT genotype. Notably, state and trait anxiety of an individual can independently be affected by the early environment. PMID: 23567893
35. In the present study demonstrated that this relationship seems to be true also for lactating mice, as 5-HTT -/- mice are characterized by increased levels of extracellular 5-HT in the brain. PMID: 23291155
36. Heterozygous SERT(+/-) mice display a general increase in grooming behavior, as indicated by more grooming bouts and more transitions between specific grooming stages. PMID: 22951260
37. stress susceptible mice showed elevated expression of tumour necrosis factor alpha and the 5-HT transporter in the pre-frontal area PMID: 23305936
38. study demonstrates that repeated swim stress increases SERT function and ventral striatum surface expression through a KOR- and p38 MAPK-dependent manner, and implicates this molecular process in stress-induced behaviors. PMID: 23223282
39. Developmental dysregulation of serotonin homeostasis has detrimental effects on neocortical circuit formation and contributes to increased vulnerability to psychiatric disorders. PMID: 22833193
40. The rsults of this study suggested that suggest that variation in 5-HTT expression causes adaptive changes in 5-HT receptor levels which are directly linked to alterations in 5-HT availability. PMID: 21846421
41. This review presented that the 5htt knockout mice show a correlation between 5-HT firing rate and depressive/resilience phenotypes. PMID: 23089640
42. ATF4 significantly activates 5-HTT transcription in vitro and time dependently binds to the cAMP response element site in the 5-HTT promoter in the mouse midbrain. PMID: 22572884
43. Down-regulation of the serotonin transporter in platelets may counteract the pro-thrombotic influence of elevated plasma serotonin. PMID: 22366712
44. SERT-deficient mice progressively develop obesity and hepatic steatosis, despite reduced food intake. PMID: 22412882
45. This study demonstrated that pre-gestational stress alterate the levels of serotonin transporter in fetal brain. PMID: 22373128
46. Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than the serotonin transporter. PMID: 21129446
47. SERT is responsible for the majority of synaptosomal uptake only at relatively low 5-HT concentrations; non-SERT mediated 5-HT uptake is substantial even at modest 5-HT concentrations. PMID: 21437992
48. Data suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction. PMID: 21857948
49. Living in a dangerous world decreases maternal care: a study in serotonin transporter knockout mice. PMID: 21787775
50. Extinction learning and memory of conditioned fear can be modulated by both the 5-HTT gene activity and social experiences in adulthood. PMID: 21818344

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KEGG: mmu:15567

STRING: 10090.ENSMUSP00000021195

UniGene: Mm.300318