Recombinant Mouse Solute carrier family 15 member 1 (Slc15a1), partial

1. Results suggest that PepT1 contributes to maintain balance of homeostasis and proper functions in the small intestine, and dysregulated miRNAs and proteins along the crypt-villus axis are highly related to this process. PMID: 27250880
2. Glycosylation of PEPT1 confers resistance against proteolytic cleavage by proteinase K, whereas a remarkable intrinsic stability against trypsin, even in the absence of N-linked glycans, was detected. PMID: 28336547
3. We tested the hypothesis that PEPT2 genotypes affect the severity and prognosis of porphyria-associated kidney disease PMID: 28031405
4. findings suggested a major role of PEPT1 in the intestinal permeability and oral absorption of 5-aminolevulinic acid PMID: 26444978
5. Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil. PMID: 26979860
6. Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport. PMID: 26320580
7. miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation. PMID: 25931122
8. PEPT1 expression is reduced during intestinal inflammation and PEPT1 is not required for muramyl dipeptide-induced immune response. PMID: 24583477
9. Data indicate that peroxisome proliferator-activated receptor-alpha (PPARalpha) activated the intestinal expression of Slc15a1 mRNA during the light period, and protein levels of PepT1 peaked before the start of the dark phase. PMID: 25016014
10. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2. PMID: 23934551
11. PepT1 deletion reduced the area under the plasma concentration-time profile (AUC0-120) of cefadroxil by 10-fold, the maximum plasma concentration (Cmax) by 17.5-fold, and increased the time to reach a maximum plasma concentration (Tmax) by 3-fold. PMID: 23959853
12. A critical role of intestinal PepT1 in improving the rate and extent of oral absorption for valacyclovir. PMID: 23924683
13. PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis. PMID: 23797361
14. These studies unequivocally demonstrate the presence of PEPT1 protein in healthy distal colonic epithelium in mice, rats, and humans and proved that the protein is functional and contributes to electrolyte and water handling in mice. PMID: 23660505
15. Intestinal PepT1 has a major influence in improving the oral absorption of valacyclovir. PMID: 23264448
16. The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet. PMID: 22031831
17. Expression of PEPT1 protein in the small intestine was increased ~2-fold in wild-type mice during fasted as compared to fed conditions. PMID: 21904935
18. PEPT1 is important for overall amino acid absorption only after high dietary protein intake when amino acid transport processes are saturated and PEPT1 can provide additional absorption capacity. PMID: 21350187
19. Compared with wild-type animals, PEPT1 null mice exhibited a 78% reduction in glycylsarcosine uptake at pH 6.0 at 37 degrees C. PMID: 20862774
20. Results from this study indicated that treatment with Lactobacillus plantarum may ameliorate colonic epithelial barrier dysfunction in IL-10 knockout mice, by modulating the apical junction complex and PepT1-mediated transport. PMID: 20884889
21. Proton-coupled electrogenic dipeptide uptake in the native small intestine, mediated by PEPT1, relies on the negative apical membrane potential as the major driving force and contributes significantly to intestinal fluid transport. PMID: 20430876
22. Pept1 mRNA was not only highly expressed in small intestine, but also detectable in gonads and large intestine of mice PMID: 16202478
23. Treatment with interleukin-1beta increased PepT1 mRNA expression in mouse proximal and distal colon and decreased PepT1 mRNA expression in jejunum and ileum. PMID: 16328452
24. In conclusion, the association of PepT1 with lipid rafts differently modulates its transport activity in polarized and nonpolarized cells. PMID: 17932227
25. PEPT1 exhibits ectopic expression in colonic inflammation PMID: 18668438
26. diet-induced obesity, that a 4-week hypercaloric diet resulted in a 46% decrease in PepT1-specific transport, because of a 30% decrease in PepT1 protein and a 50% decrease in PepT1 mRNA levels. PMID: 19144638
27. Targeted disruption of PEPT1 gene in mice significantly reduces dipeptide absorption in intestine. PMID: 19434858
28. Demonstrate a molecular mechanism underlying the regulation of colonic PepT1 expression and reveal a novel role for PepT1 in host defense via its capacity to modulate bacterial-epithelial interactions and intestinal inflammation. PMID: 19549526

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KEGG: mmu:56643

STRING: 10090.ENSMUSP00000085728

UniGene: Mm.155618