Recombinant Mouse Trans-acting T-cell-specific transcription factor GATA-3 (Gata3)

1. The enhanced Th1 and Th2 immune response in K + O immunized mice was also supported by the increased expression of Tbx21 and GATA-3 transcription factors in splenocytes. This corroborated with increased BLIMP-1 and Oct-2 protein expression. PMID: 29486619
2. Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat. PMID: 27109496
3. We have identified ZPO2 as a negative regulator of GATA3, thus providing an alternative mechanism that results in a reduction in or perhaps even loss of GATA3 during breast cancer development. PMID: 28258171
4. Findings suggest that VEGF gene expression can be suppressed by TNFSF15-stimulated activation of the JNK-GATA3 signaling pathway which gives rise to up-regulation of miR-29b. PMID: 27589684
5. RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4. PMID: 27878828
6. the model of mutually antagonistic differentiation programs driven by mutually exclusively expressed T-bet or GATA-3 does not completely explain natural CD4 T cell priming outcomes PMID: 29088218
7. MIF-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 expression and IL-13 production in the mesenteric lymph nodes PMID: 27049059
8. study demonstrates a role for HOX5 proteins in controlling lung inflammation during a model of allergic asthma. The increased inflammation in the Hox5-deficient mice was mediated by increased Th2 cell development, which was associated with regulation of Gata3 expression PMID: 28576978
9. Treg cell accumulation in intestinal tumours from APC(min/+) mice was exclusively due to the increase in KLRG1(+) GATA3(+) Treg cells. PMID: 28437001
10. GATA3 abundance regulates the recombination propensity at the Tcrb locus. PMID: 28320875
11. priming of T helper cells by IL-6-deficient antigen-presenting dendritic cells preferentially leads to accumulation of a subset of Follicular helper T cells characterized by high expression of GATA3 and IL-4. PMID: 27474166
12. Gata3 was first expressed in all developing neurons, followed by a decrease in type I primary auditory neurons as they matured. PMID: 28118374
13. Mediated by GATA3 through targeting promoter region of ORMDL3. PMID: 28031110
14. these results indicate that picroside II has protective effects on allergic asthma by reducing GATA3 expression and Th2 cytokine bias. PMID: 27870920
15. Results provide evidence for a critical role for GATA3 in the maintenance of mesangial cells and its absolute requirement for prevention of glomerular disease. PMID: 27296697
16. It is proposed that the interactions between ANXA1 and GATA-3 may provide clues to understand the immunosuppression and have potential as new therapeutic targets in immunotherapy after sepsis. PMID: 27833268
17. GATA3 is expressed in both prostate basal progenitor and luminal cells and loss of GATA3 leads to a mislocalization of PRKCZ, resulting in mitotic spindle randomization during progenitor cell division. PMID: 28285879
18. expression of wild type GATA-3 activated OPG mRNA and protein expression, while the expression of a dominant negative mutant of GATA-3 or a GATA-3 shRNA construct reduced OPG mRNA and protein levels PMID: 26216189
19. The Tce1 enhancer is both necessary and sufficient for critical aspects of Gata3 T cell-specific transcriptional activity. PMID: 26808502
20. These results suggest that Oct-1 and GATA-3/Oct-2 direct Th2 cytokine gene expression in a cooperative manner. PMID: 26840450
21. Cytokines analysis in peritoneal fluid showed that IFN-gamma was significantly increased in chlorhexidine gluconate (CG)-injected T-bet Tg mice and that IL-13 was significantly increased in CG-injected GATA-3 Tg mice PMID: 26156402
22. our results demonstrate that GATA3 is a critical regulator for NK cell terminal maturation and egress out of the bone marrow PMID: 26773150
23. Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment. PMID: 26595886
24. Data indicate that overexpression of micrRNA miR-135a alters transcription factor T-bet and GATA binding protein 3 (GATA-3) mRNA expression in allergic rhinitis (AR). PMID: 26418311
25. PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells PMID: 26361334
26. The results of the present study suggested that the therapeutic mechanism by which afzelin effectively treats asthma is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor. PMID: 25738969
27. that loss of one Gata3 allele leads to diminished expansion (and compromised development) of immature T cells as well as aberrant induction of myeloid transcription factor PU.1. PMID: 26385963
28. We herein identified a mechanism whereby the methylation of Gata3 at Arg-261 regulates the transcriptional activation of the Il5 gene in Th2 cells. PMID: 25861992
29. Itm2a is a target gene of GATA-3 that plays a minimal role in regulating the development and function of T cells PMID: 24831988
30. Data propose that control of GATA3 levels by Fbw7 contributes to the fine-tuning of T-cell development. PMID: 24820417
31. miR-183, though negatively regulated by Gata3, enhances 3T3-L1 preadipocyte differentiation and adipogenesis by targeting LRP6. PMID: 24556500
32. the pattern of GATA-3 expression sequentially produces B lineage exclusion, T lineage progression, and myeloid-lineage exclusion for commitment. PMID: 25172496
33. Inhibition of GATA3 activity or blockade of GATA3 expression may attenuate the interleukin-13 mediated asthma phenotypes. PMID: 24363163
34. role for Nkx2-5 and Gata3 in the ontogeny of the smooth muscle gastric ligaments; gastric ligaments coexpress Gata3, Nkx2-5 and Sox9; germline loss of Gata3 or conditional deletion of Nkx2-5 abrogates Sox9 expression and impairs gastric ligament smooth muscle development PMID: 24970776
35. GATA-3 overexpression in T-cells and IL-13 might play important roles in the development of dextran sulfate sodium-induced colitis. PMID: 24770638
36. Mechanistically, JARID1B was required for GATA3 recruitment to the Foxa1 promoter to activate Foxa1 expression. PMID: 24802759
37. This study demonstrates that the Isl1-Gata3 transcription regulatory axis is essential for normal pyloric development. PMID: 24674670
38. The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells. PMID: 24631153
39. Gata3 plays a generalized role in innate lymphoid cell (ILC) lineage determination and is critical for the development of gut RORgammat(+) ILC3 subsets that maintain mucosal barrier homeostasis. PMID: 24419270
40. Enforced Gata3 expression is sufficient to enhance Th2 and group 2 innate lymphoid cell activity, and leads to increased susceptibility to allergic airway inflammation after exposure to inhaled harmless antigens that otherwise induce antigen tolerance. PMID: 24415780
41. Results show the essential role of Gata3 in specifying the prosensory domain in the cochlea and in regulating the survival of spiral ganglion neurons, thus identifying a molecular mechanism underlying human HDR syndrome. PMID: 23666531
42. IL-33 or a combination of IL-2 and IL-25 induced GATA3 phosphorylation. Both p38 and GATA3 are critical for the proliferation and productionon of IL-5 and IL-13. GATA3 plays a pivotal role in the effector functions of mature natural helper cells. PMID: 23851685
43. Gata3 is independently required for the development of a pyloric outer longitudinal muscle fascicle, which is required for pyloric sphincter morphogenesis in mice. PMID: 24120474
44. Gata3 inactivation in Pten-deficient prostates accelerates tumor invasion. PMID: 23428429
45. a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization. PMID: 23920117
46. GATA-3-deficient T lymphocytes have defective responses to viral infection and alloantigen. PMID: 23708251
47. GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. PMID: 23974957
48. results presented indicate that the jal mutation is a mutant allele of the Gata3 gene on mouse Chromosome 2 PMID: 23659281
49. These results identify Gata3 as a critical early regulator of group 2 lymphoid cell development, thereby extending the paradigm of Gata3-dependent control of type 2 immunity to include both innate and adaptive lymphocytes. PMID: 23733962
50. Macelignan attenuates the severity of murine experimental asthma by suppressing IL-4 producing CD4+Th cells through inhibition of GATA-3 activation. PMID: 23643632

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KEGG: mmu:14462

STRING: 10090.ENSMUSP00000100041

UniGene: Mm.313866