Recombinant Mouse Transcription factor E2F1 (E2f1)

1. E2f1 mediates high glucose-induced neuronal death in cultured mouse retinal explants. PMID: 28825879
2. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion PMID: 28794159
3. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 to diverse repeat sequences. PMID: 27889452
4. germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma PMID: 28134624
5. E2F1 hinders skin wound healing by suppressing VEGF expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing. PMID: 27490344
6. TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells. PMID: 27932351
7. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells. PMID: 27029528
8. Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia. PMID: 26505089
9. In the initial stage of myocyte differentiation, transcription of the YB-1 gene was regulated by E2F1 and Sp1, and was then gradually replaced under the control of both MyoD and myogenin. PMID: 26279143
10. Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 in differentiated neuroblastoma cells; E2F1 is a substrate of Omi. PMID: 26238290
11. accumulating E2f1 progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f target genes and amplifies the E2f transcriptional response. PMID: 26639898
12. A role for E2F1 and E2F2 as suppressors of replicative stress in differentiating cells, and the existence of a robust E2F-p53 regulatory axis in tissue homeostasis enabling and tumorigenesis preventing is shown. PMID: 25656653
13. E2F1 promotes apoptosis of spermatogonia during the first wave of spermatogenesis, is involved in the maintenance of the spermatogonial stem cell pool in the adult and inhibits apoptosis of the meiotic germ cells. PMID: 26311345
14. Data (including data from studies in knockout/transgenic mice) suggest CDKN1B-RB1-E2F1 (cyclin-dependent kinase inhibitor 1B-retinoblastoma 1-E2F1) pathway is essential for SSC (spermatogonial stem cell) self-renewal/protection against genomic damage. PMID: 25959802
15. Conditional knockout of Poh1 alleles results in reduced E2F1 expression in primary mouse liver cells. PMID: 26510456
16. E2F1 negatively regulates both Ogt and Mgea5 expression in an Rb1 protein-dependent manner. PMID: 26527687
17. Interplay between E2F1, miR421 and Pink1 regulates mitochondrial morphology and cardiomyocyte death. E2F1 activates miR421 expression. E2F1 knockdown suppresses mitochondrial fragmentation, apoptosis and myocardial infarction by reducing miR421 levels. PMID: 26184432
18. study identifies a novel signaling pathway composed of E2F1, miR-30b and CypD that regulates myocardial necrosis. PMID: 25301066
19. limits cardiac neovascularization and functional recovery after myocardial infarction by suppressing VEGF and PlGF up-regulation through p53-dependent and -independent mechanisms, respectively PMID: 25341896
20. Rb-deficient cells hijack and redeploy Myc and E2f3 from an S-G2 program essential for normal cell cycles to a G1-S program that re-engages ectopic cell cycles, exposing an unanticipated addiction of Rb-null cells on Myc. PMID: 26192440
21. Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity PMID: 25940086
22. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 is a mechanism by which serum starvation promotes E2F1-induced apoptosis. PMID: 25257171
23. Tudor-SN is a potential substrate of G1/S phase Cyclin-Dependent Kinases, and promotes cell cycle progression by facilitating E2F-1-mediated gene transcription. PMID: 25627688
24. oncogenic activities of E2F1 and E2F3 in ErbB2- or Myc-triggered mammary tumorigenesis, and a tumor suppressor role of E2F2 in Myc-mediated mammary tumorigenesis PMID: 24276244
25. E2F1 regulates cellular senescence by inhibiting FOXO3. PMID: 25344604
26. ERBB2-dependent maintenance of E2F-1 expression is an important molecular conduit required to sustain a genetic program necessary for adult cardiovascular homeostasis and function and for the adaptive response of the heart to stress. PMID: 25246633
27. Our present study reveals a novel autophagic regulating model that is composed of E2F1, miR-325 and ARC. Modulation of their levels may provide a new approach for tackling cardiac failure. PMID: 24531537
28. showed that the D326V missense pRb bound to E2F1 but failed to interact with E2F2/3 PMID: 25088905
29. E2F1 activated early growth response (Egr)-1 expression in a biphasic fashion as described in both human and mouse hepatocytes. PMID: 24619556
30. MiR-383 promoted the expression of miR-320 which regulated granulosa cell functions by targeting E2F1 and SF-1 proteins. PMID: 24828505
31. In Rb1-deficient pituitary tumorigenesis, Skp2 deletion or p27T187A mutation converts E2F1's role from proliferative to apoptotic. PMID: 24632684
32. E2F1 promotes DNA repiar and suppresses tumor development. PMID: 24741006
33. Our study demonstrates that E2F1 contributes to physiologic brain structure and function PMID: 24460902
34. Data indicate that cultured Sfpi1(BN/BN) cells expressed elevated messenger RNA transcript and protein levels of E2F1, an important regulator of cell cycle entry. PMID: 24316397
35. AMPKalpha2 significantly contributed to stabilization and activation of E2F1 by doxorubicin, forming a positive signal amplification loop. PMID: 24398673
36. these data identify E2F1 as a key transcription factor modulating the expression of chromatin components in oligodendrocyte progenitor cells during the transition from proliferation to differentiation. PMID: 24453336
37. Ei24 is a novel E2F1 target gene contributing to the survival of p53-deficient cells upon UVC irradiation and thus may have a potential significance as a therapeutic target of certain chemotherapy for treating p53-deficient tumors. PMID: 24014029
38. These results suggest a model whereby Rb-E2f interactions are sufficient to maintain gene repression irrespective of LXCXE-dependent chromatin remodeling. PMID: 23574720
39. Rb/E2F1 axis exerts essential functions not only in maintaining epidermal homoeostasis, but also in suppressing tumour development in epidermis PMID: 22890321
40. pRb-E2F1 is an obesity suppression mechanism in arcuate nucleus POMC neurons and high fat diet-AMPK inhibits this mechanism by phosphorylating pRb in this location. PMID: 23403926
41. This study provides evidence that the histone modification and E2F1 binding are integral parts of the mechanism for Lhx2 gene expression. PMID: 23036195
42. These findings suggest that Brd2 is required for cell cycle exit and neuronal differentiation of neuroepithelial cells through the E2F1 pathway during mouse CNS development. PMID: 22885183
43. The results identify E2F8 as a repressor and E2F1 as an activator of a transcriptional network controlling polyploidization in mammalian cells. PMID: 23064264
44. E2f1-/-;mdx mice demonstrated a strong reduction of physiopathological signs of Duchenne muscular dystrophy. PMID: 22678059
45. Cardiac hypertrophy can be induced in an E2F1-independent fashion and suggest that in contrast to previous reports, targeting E2F1 may not be a good therapeutic approach. PMID: 21738823
46. Rb/E2F is required to coordinate the transition between proliferation and differentiation by controlling key aspects of differentiation through regulation of the Dlx1/Dlx2 bigene cluster. PMID: 22699903
47. Data suggest that nuclear translocation of cardiac E2F1 is enhanced by high-fat diet (HFD) concomitant with induction of pyruvate dehydrogenase kinase 4 (PDK4); HFD may initiate early cardiac metabolic alterations through cyclin D1/E2F1/PDK4 axis. PMID: 22569253
48. Transgenic-mtTFB1 mice exhibit enhanced 12S rRNA methylation in multiple tissues, increased E2F1 and apoptosis in the stria vascularis and spiral ganglion neurons of the inner ear, and progressive E2F1-dependent hearing loss. PMID: 22341444
49. JAZ plays a dual role in cell cycle regulation by both repressing E2F1 transcriptional activity and activating p53 to facilitate efficient growth arrest in response to cellular stress PMID: 21715977
50. E2F-1 and FoxO-1a belong to a complex transcriptional network that may modulate myocardial cell death during I/R injury. PMID: 21964190

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KEGG: mmu:13555

STRING: 10090.ENSMUSP00000099434

UniGene: Mm.18036