Recombinant Mouse Transcription factor MafB (Mafb)

1. MafB appears to play an important role in secondary hyperparathyroidism by regulation of parathyroid hormone and cyclin D2 expression. PMID: 28964572
2. The expression of the first protein in the classical complement pathway C1q is important for mediating efferocytosis and is reduced in Mafb-deficient macrophages. PMID: 29167450
3. present findings indicate that MafB enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages PMID: 29030012
4. Therefore, MafB promotes differentiation in postmitotic keratinocytes and simultaneously has potential to promote growth when ectopically expressed in undifferentiated basal keratinocytes. PMID: 28418611
5. MAFB localized in Leydig and Sertoli cells in testes at E18.5 while it localized in Leydig cells, Sertoli cells, and pachytene spermatocytes in adult testes. Examination revealed that MAFB-deficient testes developed normally by E18.5, and spermatogenesis was not disrupted in adult mice. MAFB MAFB might be critical for phagocytosis activity of Sertoli cells. PMID: 29324782
6. MafB controls endothelial sprouting in vitro and in vivo in postnatal retinal angiogenesis. PMID: 28959057
7. Macrophage-specific inhibition of MafB may destabilize atherosclerotic plaques in advanced lesions PMID: 27214395
8. a protective role of oxLDL-associated LPS on beta-cell function during hyperlipidemia by inducing miR-155-5p, which prevents the upregulation of MafB and beta-to-alpha-cell reprogramming. PMID: 28970282
9. Increased mafB at the common myeloid progenitor stage steers their lineage away from the megakaryocyte erythrocyte progenitor production and drives the terminal fate of these progenitors to form macrophages vs. dendritic cells, causing anemia, monocytosis, and dendritic cell loss. It is a transcriptional activator of M-CSFR and a repressor of transferrin receptors, promoting macrophages and plasmacytoid dendritic cells. PMID: 26992433
10. An elevation of MSR1 levels in infiltrating myeloid cells observed 3 d after experimental stroke was dependent on the transcription factor Mafb. Mafb deficiency in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke. PMID: 28394332
11. a Mafb-driven Cre strain was generated to determine whether any dendritic cells (DCs) identified by Zbtb46-green fluorescent protein expression originate from a Mafb-expressing population. PMID: 27810926
12. MafB deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy. PMID: 27217483
13. MafB play an important role in promoting hindbrain choroid plexus development during embryogenesis PMID: 28025141
14. Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression. PMID: 27847322
15. Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. PMID: 27181683
16. MafB and c-Maf have different expression patterns in macrophages, suggesting differences in function. PMID: 26996125
17. MAFB is an important transcription factor involved in lymphangiogenesis. PMID: 26549461
18. Study provides insights to elucidate mechanisms of gene regulation through androgen response elements present in Mafb 3'UTR for a better understanding of the processes of urethral masculinization. PMID: 26636186
19. It contributes to the development of hyperglycemia in the Mafa-deficient background in adults as well as in embryos. PMID: 25912440
20. MafB is only essential to islet alpha-cell activity and not beta-cell. PMID: 26554594
21. findings represent the first evidence that the macrophage-affiliated MafB transcription factor participates in the acceleration of atherogenesis PMID: 24445679
22. Data, including data from studies using transgenic/knockout mice, confirm the expression of Mafa and Mafb is specific to insulin-secreting cells of the pancreas. PMID: 25273397
23. Mafb-deficient microglia cultured with GM-CSF barely extended their membrane protrusions, probably due to abnormal activation of RhoA, a key regulator of cytoskeletal remodeling. MafB is a negative regulator of GM-CSF signaling in microglia. PMID: 25998393
24. high-resolution structures of the transcription factor MafB as a homodimer and as a heterodimer with c-Fos bound to variants of the Maf-recognition element PMID: 24530283
25. Mafb is expressed in male genital tubercle (GT) mesenchyme. Exogenous androgen induces its mesenchymal expression in female GTs. AR signaling is necessary for its expression. Mafb KO male GTs have defective embryonic urethral formation. PMID: 25362053
26. Mafb has a protective role in diabetic nephropathy through regulation of slit diaphragm proteins, antioxidative enzymes, and Notch pathways in podocytes. PMID: 24722438
27. MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity PMID: 23863625
28. Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice. PMID: 24040127
29. The efficiency of the MafB-induced multiple myeloma reprogramming of normal hematopoietic stem/progenitor cells to terminally differentiated malignant plasma cells is enhanced by p53 deficiency. PMID: 22983007
30. the haematopoietic progenitor population can be the target for transformation in MafB-associated plasma cell neoplasias PMID: 22903061
31. The data showed that Men1 inactivation led to MafB reexpression in mouse beta cells in vivo, and provides evidence that deregulated ectopic MafB expression may have a hitherto unknown role in adult beta cell proliferation and Men1-related tumorigenesis. PMID: 22120711
32. The homozygous kreisler mutation eliminates most of rhombomere 5 and mis-specifies rhombomere 6, abolishes an early decrease in respiratory frequency within 10 min of hypoxia and an intrinsic hypoxic activation. PMID: 21839147
33. High MafB following experimental burn plays an inhibitory role in monocyte-derived dendritic cell differentiation by regulating monocyte-colony factor receptor (M-CSFR) and GATA-1 expression. PMID: 21984745
34. results suggest that MafB regulates later steps of parathyroid development, that is, separation from the thymus and migration toward the thyroid. MafB also regulates the expression of PTH in cooperation with Gcm2 PMID: 21713993
35. Findings identify Mafb as one of the earliest direct targets of Cdx1 and show that Cdx1 plays a direct role in early hindbrain patterning. PMID: 21098558
36. Insight into the sequential manner by which MafB regulates islet beta-cell formation and maturation in mice. PMID: 20627934
37. MafB acts as a metastable switch tocontrol expression of IFN-beta. PMID: 20581830
38. expressed in the inner root sheath layers in a lineage-restricted manner and are involved in hair morphogenesis PMID: 20060689
39. Requirement for the downregulation of segmental kreisler expression prior to neuronal differentiation reflects the stage-specific roles of this gene PMID: 11880356
40. Kreisler acts during the final stages of glomerular . The levels of Podocin, the gene mutated in NPHS2, and Nephrin, the gene mutated in NPHS, are slightly reduced in kr(enu)/kr(enu) podocytes. PMID: 12217315
41. determination of dual function of Mafb in both segmentation and specification of anteroposterior identity in the hindbrain PMID: 12490204
42. Kreisler regulates maintenance and expansion of rhombomere (r) 5 and specification of r6 but is not required for r3 development. PMID: 12701106
43. Because MafA, MafB, and c-Maf were each capable of specifically binding to and activating insulin C1 element-mediated expression, our results suggest that all of these factors play a role in islet beta-cell function. PMID: 12917329
44. In Mafb(-/-) mice the preBotzinger Complex, but not major neuromodulatory groups, presents severe anatomical defects with loss of cellularity, suggesting an essential role of MafB in central respiratory control PMID: 14513037
45. Low-density lipoprotein receptor-related protein intracellular domain co-localizes with MafB to the nucleus and negatively regulates its transcriptional activity PMID: 15135046
46. These data indicate that maf-B mRNA is expressed during development of the eyelid closure in mice. PMID: 15597194
47. Initiation of Kreisler expression has direct requirement for vHNF1. PMID: 16274963
48. The data also identify Gbx2, Dlx5, Wnt2b and Otx2 as key otic genes ultimately affected by perturbation of the kr/mafB-hindbrain pathway. PMID: 16325169
49. Within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene through activation of a conserved control element found between nucleotides -77 to -51. PMID: 16443760
50. MafB may have a dual role in regulating embryonic differentiation of both beta- and alpha-cells while MafA may regulate replication/survival and function of beta-cells after birth. PMID: 16580660

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KEGG: mmu:16658

STRING: 10090.ENSMUSP00000096728

UniGene: Mm.330745