Recombinant Mouse Transcriptional enhancer factor TEF-1 (Tead1)

1. The YAP/TEAD1 complex binds to DNA element and regulates the expression of genes involved in cell growth..our data demonstrate an important role of TEAD1 in early development in mice, and the floxed TEAD1 mouse model will be a valuable genetic tool to determine the temporal and tissue-specific functions of TEAD1. PMID: 29193599
2. Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers PMID: 27578179
3. Overexpression of TEAD1 induced Treg cell differentiation. TEAD sequesters TAZ and inhibits TH17 development. PMID: 28504697
4. YAP and TEAD1, key downstream effectors of the Hippo pathway, are specifically expressed in Muller cells. We also uncovered a deregulation of the expression and activity of Hippo/YAP pathway components in reactive Muller cells under pathologic conditions. PMID: 28384715
5. Data show that TEAD family of transcription factors Tead1 and Tead4-regulated gene expression in differentiating primary myoblasts. PMID: 28178271
6. Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc RNA expression, and cells with increased Myc expression also became super-competitors. PMID: 25588835
7. The PDZ-binding motif of YAP is critical for YAP-mediated oncogenesis, and that this effect is mediated by YAP's co-activation of TEAD-mediated CTGF transcription. PMID: 24380865
8. TEAD1 regulates C2C12 differentiation through negatively regulating the expression of Ccne1, which can explain the transition between proliferation and differentiation. PMID: 23220227
9. TEAD1 is shown to be a mediator of skeletal muscle development. PMID: 21211055
10. increased TEAD-1 can induce characteristics of cardiac remodeling associated with cardiomyopathy and heart failure. PMID: 20194497
11. These results are consistent with two plausible models of cryptic MCAT enhancer regulation by Pur alpha, Pur beta, and MSY1 involving either competitive single-stranded DNA binding or masking of MCAT-bound transcription enhancer factor-1. PMID: 11751932
12. Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions PMID: 12861002
13. VITO-1, a new scalloped interaction domain-containing protein, binds to TEF1 in vitro and strongly stimulates transcription of a reporter plasmid together with TEF-1 PMID: 14762206
14. p38 MAPKs regulate TEF-1 and C/EBPbeta transcriptional activity in the absence of environmental stress. PMID: 16492136
15. Sveinsson's chorioretinal atrophy pathogenesis may be due to a loss-of-function of TEAD1 affecting the regulation of its target genes. PMID: 17689488
16. RTEF-1 bound to the element-containing region within the smooth muscle alpha-actin promoter in myofibroblasts, whereas TEF-1 was bound to the same region in differentiated smooth muscle cells PMID: 17823374
17. Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in development. PMID: 18332127
18. TEAD-1 has a role in modulating slow muscle gene expression PMID: 18978355
19. The primary cellular origin of circumpapillary dysgenesis of the pigment epithelium is within the choroid instead of the pigment epithelium. PMID: 19410955
20. A transcription cofactor required for skeletal muscle differentiation that modifies DNA target selectivity of the Transcriptional Enhancer Factor-1 (TEF-1) transcription factors. PMID: 15287000

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KEGG: mmu:21676

UniGene: Mm.24685