Recombinant Mouse Transient receptor potential cation channel subfamily M member 5 (Trpm5), partial

1. Both TRPM4 and TRPM5 are required for normal responses to bitter, sweet, and umami stimuli. PMID: 29311301
2. This physiological and behavioral results indicate that TRPM5-MCs play a protective role in maintaining the olfactory function of the mammalian main olfactory epithelium. PMID: 28612045
3. conclude that nAChR subunits are expressed in Trpm5-positive TRCs and their expression levels are differentially altered by chronic oral exposure to nicotine and ethanol PMID: 29293602
4. propose that Skn-1a/Pou2f3 is the master regulator for the generation of the Trpm5-expressing microvillous cells in multiple tissues PMID: 29216297
5. This study demonstrate that Trpm5 is transiently expressed in a subpopulation of mature OSNs in the embryonic olfactory epithelium, indicating that Trpm5 channels could play a specific role in utero during a narrow developmental time window. PMID: 28188885
6. The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores PMID: 26571400
7. The present findings confirm and extend our recent findings that Trpm5 KO mice express significant preferences for 8% glucose and galactose. PMID: 25497884
8. Skn-1a is expressed in a minority of Mash1-positive olfactory progenitor cells and a majority of Trpm5-expressing microvillous cells in the main olfactory epithelium. PMID: 24428937
9. The Trpm5 (but not T1r3) signaling is essential for starch preference, Trpm5 KO mice can learn to prefer starch based on its postoral effects. PMID: 23547138
10. This study show that olfactory sensory neurons expressing TRPM5 respond to pheromones, but not to regular odors through the opening of CNG channels leading to Ca2+ gating of TRPM5 PMID: 24573286
11. Evidence suggests that TRPM5 plays a role in mediating transduction for putative pheromones under conditions of reduced chemosensory input. PMID: 23613997
12. The results suggest that pharmacological or genetic alteration of TRPM5 activity modulates the benzamil-insensitive NaCl chorda tympani response and its modulation by TRPV1 agonists. PMID: 23639808
13. The findings of this study indicated that T1r3 and Trpm5 play critical roles in carbohydrate-induced dietary obesity. PMID: 22683548
14. There may be a TRPM5-independent transduction pathway for detecting the taste of sweetening substances. PMID: 21987728
15. some amygdalopetal mitral cells extended dendrites to non-TRPM5-GFP glomeruli and vice versa, suggesting that, although significant overlapping glomerular innervation is observed between these two features, it is not absolute PMID: 22120520
16. The prototypical long-chain free fatty acid stimulus, linoleic acid, depolarizes tumor cells in vitro via activation of TRPM5. PMID: 21998136
17. FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Fxyd6 is coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the taste signal transduction pathways. PMID: 21670532
18. Together, these studies show that TRPM5 channels play an essential role in fatty acid transduction in mouse taste cells PMID: 21653867
19. discussion of data from various lines of investigation on the role of TRPM4 and TRPM5 in glucose-stimulated insulin secretion in pancreatic islets PMID: 21099334
20. membrane voltage initiated by TRPM5 channels is required for ATP secretion during taste reception PMID: 20498227
21. Results describe a major role for TRPM5 in glucose-induced insulin secretion beyond membrane depolarization. PMID: 20393858
22. TRPM5, a Ca(2+)-activated monovalent cation channel, is a positive regulator of glucose-induced insulin release. PMID: 20194741
23. functions as a cationic channel that is gated when internal calcium stores are depleted and may be responsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet compounds. PMID: 12368808
24. regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system PMID: 14657398
25. TRPM5 activated at lower Ca2+ concentration than TRPM4 when [Ca2+]i was raised. Different Ca2+ concentrations gave a difference in Ca2+ sensitivity between TRPM4 and TRPM5, with EC50 values of 20.2+/-4.0 microM & 0.70+/-0.1 microM, respectively. PMID: 15670874
26. data show that extracellular acidification acts through specific residues on transient receptor potential cation channel, subfamily M(TRPM5) to block conduction through two distinct but related mechanisms PMID: 15731110
27. TRPM5 is a highly temperature-sensitive, heat-activated channel: inward TRPM5 currents increase steeply at temperatures between 15 and 35 degrees C PMID: 16355226
28. mouse TRPM5 gene encodes a protein of 1,158 amino acids that is proposed to have six transmembrane domains and to function as a tetramer--{REVIEW} PMID: 17217064
29. TRPM5-expressing olfactory sensory neurons that project axons to glomeruli in the ventral area of the main olfactory bulb are involved in processing of information from semiochemicals PMID: 17267604
30. Association between taste perception and alcohol intake, we used three different mutant mice, each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5. PMID: 17376151
31. In addition to transduction channels encoded by the TRPM5 gene, taste cells have a second type of calcium activated cation channel less sensitive to intracellular calcium. PMID: 17522321
32. We consider TRPM5 to be an intrinsic signaling component of mammalian chemosensory organs, and provide evidence for brush cells being an important cellular correlate in the periphery. PMID: 17610722
33. This study investigated the role of these signaling proteins in the preference for fat, starch, and starch-derived polysaccharides, using Trpm5 knockout and alpha-gustducin knockout mice. PMID: 17652359
34. that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation. PMID: 17925404
35. inhibition of TRPM5 by bitter compounds constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway. PMID: 18070821
36. the TRPM5-expressing cells respond to a variety of chemicals at high exposure levels typical of irritants and are positioned in the nasal cavity appropriately to monitor inhaled air quality. PMID: 18160424
37. that trpm5-/- mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content. PMID: 18367093
38. Active pharmaceutical ingredients were identified for which EC50s were essentially identical in both mouse strains, indicating a TRPM5-independent alternative aversive pathway. PMID: 18797244
39. We provide morphological and immunocytochemical characterization of the TRPM5-expressing microvillous cells in the main olfactory epithelium PMID: 19025635
40. Report the existence of multiple transduction pathways underlying responses to sugars: a TRPM5-independent gurmarin temperature sensitive pathway for glucose. PMID: 19211717
41. Sensory attributes of complex tasting divalent salts are mediated by TRPM5 in mice. PMID: 19244541
42. Solitary chemosensory cells are likely to secrete the bioactive peptides into the intestinal lumen in response to dietary factors; release of the opioid peptides requires the Trpm5 ion channel. PMID: 19272386
43. Essential sensory transduction component from taste GPCRs for sweet, bitter, umami tastes PMID: 12581520

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KEGG: mmu:56843

STRING: 10090.ENSMUSP00000009390

UniGene: Mm.286668