Recombinant Mouse Transient receptor potential cation channel subfamily V member 5 (Trpv5)

1. life-long challenge of Ca2+ homeostasis present in Trpv5-/- mice causes accelerated bone aging and a low cortical and trabecular bone mass phenotype PMID: 27102152
2. beta-gal is present in the pro-urine from where it is thought to stimulate TRPV5 activity. PMID: 26747426
3. A novel primary cell model with TRPV5-dependent Ca(2+) transport characteristics was successfully established. PMID: 24557712
4. Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5. PMID: 24828496
5. The expression of TRPV5 channel is regulated by estrogen via estrogen receptor in osteoblasts. PMID: 24150765
6. Uromodulin upregulates TRPV5 by decreasing caveolin-1 dependent endocytosis of TRPV5. PMID: 23466996
7. In colitis in mice, tumor necrosis factor and interferon-gamma reduced expression of Klotho, which otherwise would protect TRPV5 from hypersialylation and cytokine-induced TRPV5 endocytosis, UBR4-dependent ubiquitination, degradation, and Ca(2+) wasting. PMID: 23747339
8. The TRPV5 S682P mutant is a functionally significant factor in autosomal dominant hypercalciuria. PMID: 23383183
9. promoter driven Cre recombinase expression will be useful for inducing DCT2 and CNT specific gene silencing of various channels, pumps, carriers, and receptors PMID: 21290301
10. Calcitonin augments the renal reabsorptive capacity for Ca(2+). This increase is likely to occur independently of TRPV5. PMID: 19965988
11. TrpV5 mediates basal renal calcium absorption in null mutant mice lacking calcium channel beta3 subunits (CaVbeta3) and multimeric calcium channel entry via distal convoluted renal tubules. PMID: 19767875
12. found in stria vascularis, organ of Corti, vestibular sensory cells and dark cells, and less intensely in the spiral and vestibular ganglion cells, in both old and young mice PMID: 19922080
13. the key function of TRPV5 is in active Ca2+ reabsorption and it has an essential role in Ca2+ homeostasis PMID: 14679186
14. demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3 PMID: 15665527
15. Hypervitaminosis D is of crucial importance to maintain normocalcemia in impaired Ca(2+) reabsorption in TRPV5 knockout mice. PMID: 16148038
16. TRPV5 is stimulated by klotho; klotho hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane PMID: 16239475
17. These data demonstrated the important role of Rab11a in the trafficking of TRPV5 and TRPV6. PMID: 16354700
18. binding site for NHERF4 localized in a conserved region in the carboxyl terminus of TRPV5 and was distinct from the binding site of the PDZ protein NHERF2. NHERF4 predominantly localized at the plasma membrane of X. PMID: 16565876
19. downregulation of TRPV5 and TRPV6 is likely involved in the impaired Ca2+ (re)absorption during aging PMID: 16705151
20. One aspect of vestibular dysfunction in Pendred syndrome is a pathological elevation of endolymphatic [Ca(2+)] due to luminal acidification and consequent inhibition of TRPV5/6-mediated Ca(2+) absorption. PMID: 17200157
21. Unraveling molecular mechanisms of TRPV5 channel regulation by antiaging hormone klotho, tissue kallikrein & extracellular pH demonstrated existence of novel regulatory mechanisms of active calcium reabsorption acting from tubular lumen[review] PMID: 17565273
22. Klotho participates in specific removal of alpha2,6-linked sialic acids and regulates cell surface retention of TRPV5 through this activity PMID: 18606998

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KEGG: mmu:194352

STRING: 10090.ENSMUSP00000031901

UniGene: Mm.135734