Recombinant Mouse Tyrosine-protein kinase ABL1(Abl1) ,partial

Code CSB-YP001105MO
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Source Yeast
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Code CSB-EP001105MO
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Source E.coli
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Code CSB-EP001105MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001105MO
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Source Baculovirus
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Code CSB-MP001105MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Abl1
Uniprot No. P00520
Alternative Names Abl1; AblTyrosine-protein kinase ABL1; EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (By similarity). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair
Gene References into Functions
  1. WAVE2/c-Abl survival signal required at the hematopoietic stem cell (HSC) fetal liver to marrow transition that confers fitness to the HSC for marrow hematopoiesis PMID: 29915352
  2. Results indicate that c-Abl may play roles in preimplantation embryo development, especially in TE formation and differentiation. PMID: 29556632
  3. c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation. PMID: 29022905
  4. c-Abl phosphorylation of Mdm2 has a role in regulation of p53 tumor suppression and bone marrow failure PMID: 27956626
  5. BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. PMID: 27871935
  6. These results uncover a murine hepatic steatosis regulatory axis consisting of ABL1-PPARgamma2-MLL4, which may serve as a target of anti-steatosis drug development. PMID: 27806304
  7. this study shows that signaling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse PMID: 28605050
  8. ABL potentiated the assembly and activation of the RUNX2-TAZ master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma-mediated adipogenesis. PMID: 27797343
  9. Normal ABL1 is a tumor suppressor in BCR-ABL1-induced leukemia. ABL1 inhibits expansion and proliferation of BCR-ABL1-expressing leukemic stem cells. Allosteric stimulation of the normal ABL1 kinase activity enhanced the antileukemia effect of ABL1 tyrosine kinase inhibitors. PMID: 26864341
  10. the ABL family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis. PMID: 28380378
  11. p38a as a major substrate of c-Abl both in vitro and in vivo and c-Abl-mediated phosphorylation is critical for the dimerization of p38a. PMID: 26517532
  12. Our data show that: i) HDAC2 levels and activity are increased in NPC neuronal models and in Npc1(-/-) mice; ii) inhibition of c-Abl or c-Abl deficiency prevents the increase of HDAC2 protein levels and activity in NPC neuronal models PMID: 26603102
  13. The resistance in BCR-ABL1 cells resulted either from the Y253H mutation in the BCR-ABL1 gene or incubation in increasing concentrations of imatinib. PMID: 26251899
  14. These results reveal a new pathway in the DNA damage response wherein ABL-dependent tyrosine phosphorylation of DGCR8 stimulates the processing of selective primary miRNAs. PMID: 26126715
  15. These findings connect the EphB signaling pathway to the regulation of intestinal adenoma initiation via Abl kinase. PMID: 25834110
  16. overexpression of Id2 in primary alveolar epithelial cells promotes proliferation by inhibiting a retinoblastoma protein/c-Abl interaction leading to greater c-Abl activity. PMID: 25661109
  17. The study demonstrates a previously unrecognized mechanism that controls insulin expression through c-Abl-regulated NKx2.2 and GLUT2. PMID: 24835010
  18. Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells. PMID: 25168238
  19. LPS-induced paxillin phosphorylation at Y31 and Y118 was mediated by c-Abl tyrosine kinase PMID: 25795725
  20. c-Abl modulates tumor cell sensitivity to antibody-dependent cellular cytotoxicity. PMID: 25300860
  21. Data (including data from mouse mutant strains) suggest that neuropilin-1 in vascular endothelium contributes to angiogenesis via VEGFA-independent mechanism involving Abl1 signaling in the extracellular matrix in VEGFA-independent mechanism. [REVIEW] PMID: 25233427
  22. Grb10 is involved in BCR-ABL-positive leukemia in mice. PMID: 25249015
  23. Data indicate that plasmacytomas of each genotype expressed high levels of v-abl gene. PMID: 24986687
  24. c-Abl was activated during the early phase of mouse 3T3-L1 preadipocyte differentiation. c-Abl activity was essential and its inhibition blocked differentiation to mature adipocytes. c-Abl directly controlled the expression and activity of PPARgamma2. PMID: 25368164
  25. findings reveal a novel regulatory role of c-Abl in Jak2 activation induced by IL-3 cytokine growth factor in 32D hematopoietic cells PMID: 24923444
  26. C-Abl tyrosine kinase was found to be an upstream activator of neuronal apoptosis and mitochondrial dysfunction. PMID: 24510275
  27. Data indicate that ABL1 forms a complex with neuropilin 1 (NRP1) in endothelial cells (ECs). PMID: 24863063
  28. Abl Kinase Activity Is Required for VEGF- and Thrombin-Induced Disruption of Endothelial Adherens Junctions. PMID: 24367707
  29. Altered expression of Abl in airway smooth muscle may play a critical role in the development of airway hyperresponsiveness and airway remodeling in asthma. PMID: 24112389
  30. Suggest that HS-438 may be a novel drug candidate with the therapeutic potential to target BCR-ABL and overcome imatinib resistance in patients with chronic myeloid leukemia. PMID: 24657654
  31. ABL-MyoD signaling coordinates DNA repair and transcription in myoblasts. PMID: 24056763
  32. cGMP, through activation of PKGI, inhibits c-Abl, leading to increased key antioxidant enzymes and resistance to lung endothelial oxidant injury. PMID: 24401847
  33. c-Abl mediates angiotensin II-induced apoptosis in podocytes. PMID: 23515840
  34. IRF8-rescued BCR-ABL-expressing dendritic cells were capable of inducing CTLs more efficiently than control dendritic cells. PMID: 24242069
  35. Data indicate thate TGFbeta activates the ABL1 pathway in the absnce of TGFbeta receptor type II (TbetaRII) during tongue development. PMID: 23950180
  36. activation of c-Abl is an important step, which induces into two signaling pathways involving noncanonical PI 3-kinase and canonical Smads to integrate BMP-2-induced osteogenesis. PMID: 23821550
  37. Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. PMID: 23660976
  38. Intrafemoral transplantation of BCR-ABL-transduced Cbl-b(-/-) cells revealed equivalent latency of disease development to the wild-type transplants PMID: 23160449
  39. Data show that T315I-mutated BCR-ABL is functional at the stem cell level, conferring to murine embryonic stem cell (mESC)-derived leukemic cells a long-term hematopoietic repopulation ability. PMID: 23287417
  40. A signaling circuit involving Abl and p38MAPK is required downstream of Met for the survival of embryonic hepatocytes, via qualitative regulation of the p53 transcriptional response PMID: 22889954
  41. The results of this study suggest that the interferon signaling pathway may play a role in the pathologic processes caused by c-Abl expression in neurons. PMID: 22938163
  42. The results reveal a receptor-proximal switch mechanism by which Mig6 actively senses EGF deprivation to directly activate proapoptotic c-Abl. PMID: 22975324
  43. tyrosine kinases of the Abl family are present in podosomes formed by murine and human macrophages. PMID: 22733220
  44. Abl and Arg play complementary, nonredundant roles in the phagocytosis of opsonized beads and Leishmania PMID: 22665498
  45. Identify c-Abl as a regulator of bone morphogenetic protein signalling pathways and uncover a role for c-Abl in p16(INK4a) expression and osteoprogenitor expansion. PMID: 22729085
  46. Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice. PMID: 22408137
  47. ABL1 regulates spindle orientation in adherent cells and mammalian skin PMID: 22252550
  48. STAT5a/b is essential for the induction of CML-like leukemia by BCR-ABL1 and of polycythemia by JAK2(V617F). PMID: 22234689
  49. the stage-specific protein pattern of the mammalian c-Abl tyrosine kinase presented a good correlation with the mouse estrus cycle and may have a regulative function during the uterine remodeling. PMID: 22143492
  50. the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl PMID: 22199356
  51. ZnMt3 in cultured astrocytes may be a normal component of c-Abl activation in EGF receptor signaling PMID: 21900236
  52. The data confirm that BCR-ABL promotes ROS and demonstrate that NF-kappaB prevents excessive levels. PMID: 21625221
  53. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis PMID: 21900237
  54. Study shows that an intramolecular interaction between the SH2 and kinase domains in Bcr-Abl is both necessary and sufficient for high catalytic activity of the enzyme. PMID: 22000011
  55. c-Abl regulates Th cell differentiation in a T-bet-dependent manner PMID: 21690296
  56. these results demonstrate a role for c-Abl in uterine remodeling during decidualization, implantation, and placentation throughout gestation PMID: 21249431
  57. (18)F-SKI696 is taken up in vivo by tumors that overexpress Bcr-Abl PMID: 21764785
  58. p90RSK2 is dispensable for BCR-Abl-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in Flt3-internal tandem duplication-induced hematopoietic transformation. PMID: 21527514
  59. Abrogation of c-Abl kinase activation resulted in higher H2AX phosphorylation levels and higher numbers of post-irradiation gammaH2AX foci, consistent with a role of c-Abl in DSB repair regulation. PMID: 21364621
  60. Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia. PMID: 21263154
  61. This study demonstrates that PDGFbeta receptors act via an interaction with Abl kinase and Rho kinase to regulated cytoskeletal regulation of NMDA receptor channels in CA1 pyramidal neurons. PMID: 19077273
  62. The c-Abl is bound to the chromatin and shows enhanced interaction with Atm and Atr in response to DNA damage. PMID: 20798688
  63. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.[Bcr-Abl] PMID: 18813851
  64. Id2 deficient mice in a C57BL/6 genetic background exhibit increased cellularity in the granulocyte/myeloid progenitor compartment and show significantly higher numbers of maturing neutrophils.[Bcr-Abl] PMID: 18725623
  65. a direct link between genotoxic stress-activated c-Abl kinase signaling and Mdm2-Mdmx complex formation PMID: 21081495
  66. Abl kinase signaling plays a critical role in invadopodia formation and function PMID: 20937825
  67. The c-Abl can be proapoptotic or antiapoptotic through different pathways, and c-Abl regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in c-Abl dependent antiapoptotic pathways. PMID: 20150913
  68. These findings provide evidence that c-Abl participates in modulating Pitx1 expression in the apoptotic response to DNA damage. PMID: 20563669
  69. These data provide evidence that Abl family kinases reduce ganglioside turnover in the plasma membrane by inhibiting host cell sialidase activity. PMID: 20181697
  70. a BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice PMID: 19823681
  71. IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability PMID: 19829692
  72. These results suggest that hyperoxia induces caveolin-1-dependent, c-Abl-mediated dynamin 2 phosphorylation required for recruitment of p47(phox) to caveolin-enriched microdomains and subsequent ROS production in lung endothelium. PMID: 19833721
  73. This investigation establishes Abl as a potent mediator of mammary epithelial cell identity, and as a suppressor of oncogenic transforming growth factor-beta signaling during mammary tumorigenesis. PMID: 19690215
  74. A mouse model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PMID: 12032333
  75. the involvement of signaling molecules downstream of Jak kinases(Akt, PI3-K, and Ras) in v-Abl-induced cellular proliferation, apoptosis, and tumorigenesis PMID: 12130510
  76. transformation by v-Abl blocks B cell development PMID: 12469118
  77. expression of c-Abl is required for oxidative stress-induced caveolin-1 phosphorylation. PMID: 12531427
  78. c-Abl-mediated phosphorylation of Mena is regulated by Abi-1 PMID: 12672821
  79. Data show that phosphorylation at distinct sites in Abl and Arg and have additive effects on Abl and Arg kinase activation. PMID: 12748290
  80. c-Abl and Arg regulate catalase and that this signaling pathway is of importance to apoptosis in the oxidative stress response PMID: 12777400
  81. Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. PMID: 12796783
  82. c-Abl and Arg associate with glutathione peroxidase 1 (GPx1), and this interaction is regulated by intracellular oxidant levels. The c-Abl and Arg SH3 domains bind directly to a proline-rich site in GPx1 at amino acids 132-145. PMID: 12893824
  83. differential utilization of the p53 and c-Abl/p73 pathways by different tumor cell line. PMID: 12928501
  84. findings indicate that, in addition to stimulating catalase activity, c-Abl and Arg promote catalase degradation in the oxidative stress response PMID: 12950161
  85. although both c-Abl and Arg kinases are activated and form complexes with proteins in the PDGFR signaling pathway, only c-Abl functions downstream of PLC-gamma1 to mediate chemotaxis PMID: 14993293
  86. Our data suggest a novel pathway by which c-Abl transduces signals to the actin cytoskeleton through phosphorylating Dok1 Y361 and recruiting Nck. PMID: 15148308
  87. These findings suggest that Bim plays an important role in the apoptosis of early hematopoietic progenitors and that Bcr-Abl supports cell survival in part through downregulation of this cell death activator. PMID: 15226421
  88. loss of function of c-abl facilitates some types of transformation PMID: 15378021
  89. F-actin may reinforce the autoinhibitory interactions to regulate Abl kinase and inhibition can be relieved through phosphorylation and/or protein interactions with the Abl PRL region PMID: 15632178
  90. suppression of normal hematopoiesis in BCR-ABL-induced leukemia is an active process involving secretion of the cell death-inducing factor 24p3 by mouse leukemia cells PMID: 15735695
  91. TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression PMID: 15961388
  92. We concluded that cytoplasmic Abl operates on a Rac/JNK and a Rac/Nox pathway for PDGF-induced Myc induction and DNA synthesis. PMID: 16076903
  93. c-Abl promotes the induction of EGR1 through the MEK/ERK pathway in regulating apoptotic response to oxidative stress. PMID: 16091742
  94. analysis of a novel Abl family kinase-dependent Fc gammaRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses PMID: 16115887
  95. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells PMID: 16297667
  96. The Src homology 2 domain of Abl, a myristoylated and membrane-localized protein, interacts directly with phosphoinositides through a multifunctional basic site that overlaps the phosphotyrosine pocket. PMID: 16611216
  97. kinase-independent function of c-Abl in a ubiquitin-proteolytic pathway that regulates the damage recognition step of nucleotide excision repair PMID: 16713579
  98. c-Abl represents a target downstream of phosphatidylinositol 3-kinase-activated PAK2, which differentiates TGF-beta signaling in fibroblasts and epithelial cell lines. PMID: 16867995
  99. c-Abl activates WAVE2 via tyrosine phosphorylation to promote actin remodeling in vivo; Abi-1 forms the crucial link between these two factors PMID: 16899465
  100. Tyrosine phosphorylation of transcription factor c-Jun by c-Abl protects c-Jun from Itch-mediated ubiquitination and degradation. PMID: 16901904

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Subcellular Location Cytoplasm, cytoskeleton, Nucleus, Mitochondrion
Protein Families Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
Tissue Specificity Widely expressed.
Database Links

KEGG: mmu:11350

STRING: 10090.ENSMUSP00000075167

UniGene: Mm.1318

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