Recombinant Mouse Tyrosine-protein kinase Fyn (Fyn)

1. Our findings suggest a mechanism, by which a decrease in miR-125a-3p during oocyte maturation facilitates GVBD by allowing Fyn up-regulation and the resulting stabilization of the interaction between actin and A-type lamins. PMID: 28533542
2. Fyn and Lyn as important factors that promote Plasmacytoid dendritic cell responses. PMID: 28368000
3. these results suggest that Nrf2 plays a central role in the prevention of Ang II-induced cardiomyopathy, and SFN prevents Ang II-induced cardiomyopathy partially via the Akt/GSK-3beta/Fyn-mediated Nrf2 activation. PMID: 29353218
4. This study reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons. PMID: 28363782
5. The results of this study suggested the existence of a potential DEP-1-Fyn axis in the regulation of microglial functions. PMID: 27859601
6. These results suggested that Fyn has a regulatory role in iNOS expression in astrocytes during neuroinflammatory responses. PMID: 29180007
7. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation. PMID: 28864542
8. loss of Fyn in the kidney prevents unilateral ureteral obstruction-induced tubulointerstitial fibrosis, mediated by a reduction in STAT3 phosphorylation PMID: 27616741
9. results show that Fyn kinase is an important positive effector of TGF-beta-induced chemotaxis through the control of phosphatase PP2A activity and this is relevant to pathological processes that are related to TGF-beta-dependent mast cell migration PMID: 28586109
10. In summary,MAGI-2 and Fyn protect dendrin from Nedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes. PMID: 28539383
11. FYN is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling PMID: 27525436
12. The results of this study suggested that Fyn-mediated NR2B signaling plays a critical role in regulation of prediabetic neuropathy and that the increased expression/function of NR2B subunit-containing NMDARs may contribute to the progression of neuropathy in type 2 diabetes PMID: 27146985
13. Fyn acts as a regulatory nexus between solar UV, ROS and signal transduction during skin carcinogenesis. PMID: 26686094
14. We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues. PMID: 28637841
15. data show that Fyn kinase is activated after TLR4 triggering and exerts an important negative control on LPS-dependent TNF production in mast cells controlling the inactivation of PP2Ac and activation of PKCalpha/beta necessary for the secretion of TNF by VAMP3(+) carriers PMID: 27183589
16. Fyn deficiency alters retinal morphology and adhesion properties of Muller cells. Fyn deficiency parallels a decreased optokinetic response to visual stimuli in vivo. PMID: 26808221
17. Fyn mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation PMID: 26881253
18. MOBP synthesis is stimulated by Fyn activity. PMID: 26801084
19. Fyn expression was elevated in abortion-prone mice PMID: 26892111
20. Fyn facilitates mitotic spindle formation through the increase in microtubule polymerization, resulting in the acceleration of M-phase progression. PMID: 26365631
21. These results suggest the critical physiological role of TRL4-Fyn interaction in the modulation of PAI-1-tPA axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries. PMID: 25106729
22. total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn PMID: 25340851
23. Thy-1 facilitates the recruitment of membrane raft-residing signaling molecules such as Fyn kinase and the SFK regulator, Csk binding protein (Cbp), to focal adhesions via its direct coupling of integrins and raft domains. PMID: 26459603
24. The SH2 domain of Fyn plays an essential role in Reelin signaling transduction, and an SH2 domain mutant disturbs neuronal migration in a dose-dependent manner. PMID: 24912779
25. A synergistic regulation of Fyn signaling was found in corpus striatum regulated by protein tyrosine phosphate. PMID: 25951993
26. This study demonstrate that both the tyrosine kinase Fyn and the serine/threonine kinase PKCdelta are differentially expressed in microglia and astrocytes. PMID: 26157004
27. The expression of Fyn is protective in acute chemical-induced colitis and promotes recovery from disease. PMID: 25877924
28. The aspartic acid of Fyn at 390 is indispensable for the radial migration. PMID: 25251774
29. The normal levels of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate observed in the FynKO liver extracts suggested normal triose kinase function PMID: 24312371
30. identify Fyn-centric gene networks influencing variance in ethanol LORR. Such networks may also inform future design of pharmacotherapies for the treatment and prevention of alcohol use disorders PMID: 24312422
31. SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types. PMID: 24045941
32. Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. PMID: 24036998
33. Fyn kinase is required for optimal humoral responses PMID: 23593269
34. cAMP-dependent protein kinase (PKA)/Fyn/GluN2-containing NMDA receptor GluN2BR signaling plays a critical role in triggering GluN2BR hyperfunction and pain hypersensitivity during inflammation. PMID: 21054385
35. Our findings suggest a role for Fyn kinase in neuronal death after neonatal hypoxic-ischemic injury PMID: 23127881
36. Data from knockout mice suggest that Fyn is important regulator of whole-body integrative metabolism that coordinates adipose tissue expansion, inflammation, and insulin sensitivity in states of nutrient excess (i.e., diet-induced obesity). PMID: 23321073
37. Overexpression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. PMID: 23284724
38. Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). PMID: 23438599
39. Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. PMID: 22745922
40. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. PMID: 23012656
41. mechanism underlying impaired TCR signaling and subsequent memory cell anergy must involve a Fyn signaling pathway given that the suppression of Fyn activity restores CD3/ZAP-70 complex formation and TCR proximal signaling PMID: 22386537
42. our results demonstrate that Fyn kinase downregulates nonmuscle myosin II activity, thus promoting oligodendrocyte morphological differentiation. PMID: 22437915
43. Fyn is identified as a possible novel regulator of the developmental balance between T helper (Th)17 type and regulatory T (TREG) cell subsets. PMID: 22539787
44. Fyn relays RANK/RANKL signal to the costimulatory DAP12/FcRgamma-mediated signals. PMID: 22387224
45. Fyn is not required for the pathogenesis of Bcr-Abl-mediated leukemias. PMID: 22189847
46. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. PMID: 22450804
47. loss of Fyn at early stages of disease increases soluble Abeta accumulation and worsens spatial learning in the absence of changes in tau phosphorylat in Alzheimer's disease. PMID: 21741124
48. These findings are consistent with a model in which FYN kinase plays an important role in proper shaping of the head and acrosome within the testis and possibly an additional role in the sperm acrosome reaction. PMID: 21918125
49. The data of this study indicated that Fyn differentially affects spine density and morphology in the cortex and hippocampus and has age-dependent effects on dendritic spine formation and spine morphology in vivo PMID: 21872217
50. TM4SF10, possibly through ADAP, may regulate Fyn activity PMID: 21881001

Show More

Hide All

KEGG: mmu:14360

STRING: 10090.ENSMUSP00000097547

UniGene: Mm.4848