Recombinant Mouse Uncharacterized protein C1orf106 homolog

Code CSB-YP749247MO
MSDS
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Source Yeast
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Code CSB-EP749247MO
MSDS
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Source E.coli
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Code CSB-EP749247MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP749247MO
MSDS
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Source Baculovirus
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Code CSB-MP749247MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Inava
Uniprot No.
Alternative Names
Inava; Innate immunity activator protein
Species
Mus musculus (Mouse)
Expression Region
1-663
Target Protein Sequence
MLQMPKLNEI PPGRGGPGEP WGEGRWAGPT GPEAARPARG ARGQARGARA RWDSWEHSRL PTHPGPGWDQ CSPSFLCAPS SQKLIMESKD EVSDSDSGII LQSGPDSPVS PMKELTNAVR KQQRALEARL EACLEELRRL CLREAELTGT LPAEYPLKPG EKAPKVRRRI GAAYKLDEWA LHREDPLSSL ERQLALQLQI TEAARRLCAE ENLSRQARRQ RKHAALQEEK KLRDLQRCLG DRRRNSEPPP TTVPSLGREL SASDDSSLSD GLLLEEEDSQ APKPPPESPA PPSRPLPPQS LEGLQPTGPE SGGQERAPIQ NSPWKETSLD HPYEKPRKSS ELSSESSSPA TTPQDQPNPS SLWVLDAASY HVVPIRNVPG QRQGRTSAPA TPEMQGRRGQ SQSLRVDSFR AGAEGRGRSA FPRRRPTHYT VTVPDSCFTP GKPPLPHPAC HSCSEDSGSD VSSISHPTSP GSSSPDISFL RPLCLPEPPR HRGAWGPACG RELAPHYSKL LLPAGYFPTG RYVMVAEGHL PPGEWELCRA AVGAAYDEEG APLRYQRLVP SHSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS SRPHSLDRQG AFRVRSLPPG RESFGRASGP RTQVPPVYVL RRSTDGAPVQ VFVPENGEII SQV
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
Subcellular Location
Nucleus. Cytoplasm.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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