Recombinant Mouse Urocortin (Ucn)

1. Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%. PMID: 28140406
2. Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus PMID: 27053649
3. it is shown that CRH and UCN upregulate galectin-1 expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1. PMID: 25473847
4. This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation. PMID: 25358399
5. CNTF activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo. PMID: 23626705
6. The absence of the CB1 receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour. PMID: 22734681
7. EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward. PMID: 22046429
8. CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise PMID: 21627635
9. Ucn1 gene was downregulated in 5-HTT KO and upregulated in 5-HTT TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT mutant mice PMID: 21075611
10. This study provides provide evidence for leptin actions that go beyond the hypothalamus and proposes that leptin can directly influence the activity of the midbrain Ucn1 neurons. PMID: 21209012
11. The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in the perioculomotor area suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism. PMID: 20064491
12. Ucn1, CART and nesfatin-1/NUCB2 are specifically involved in the response of Edinger-Westphal nucleus neurons to acute stress in the mouse PMID: 20043894
13. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. PMID: 12091910
14. Edinger-Westphal nucleus urocortin-expressing neurons mount a response to acute challenge in transgenic mice overexpressing corticotropin-releasing factor. PMID: 14706771
15. Urocortin induces macrophage apoptosis via Corticotropin-Releasing Factor Receptor-2. PMID: 16054139
16. Dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding. PMID: 16338088
17. UCN and AM prevent lethal endotoxemia by decreasing the local and systemic levels of a wide spectrum of inflammatory mediators, including cytokines, chemokines, and the acute phase protein serum amyloid A PMID: 16723707
18. CRF and urocortin promote the survival of cultured cerebellar GABAergic neurons through the type 1 CRF receptor PMID: 16778399
19. An important role for UCN1 in the HPA axis adaptation to repeated restraint and in the corticosterone response to a cold environment. PMID: 17456638
20. UCN located in mouse spermatozoa and exerted inhibitory effects on male reproductive functions including motility and acrosome reaction PMID: 17495470
21. urocortin modulates T-type Ca(2+) channel by interacting with CRF-R1 via the activation of PKC signal pathway in MN9D cells PMID: 17506983
22. the Ucn-CRH receptor system may be regulated by two major forms of cardiac stresses, i.e. oxidative and inflammatory stress, and may play a critical role in cardiac stress adaptation in heart diseases PMID: 19318426

Show More

Hide All

KEGG: mmu:22226

STRING: 10090.ENSMUSP00000035321

UniGene: Mm.377116