||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
||Cytoplasm, Cytoplasm, cytoskeleton, Cell junction, focal adhesion, Cell junction, tight junction, Cell projection, lamellipodium membrane, Cell projection, filopodium membrane
||Highly expressed in thymus and spleen. Lower levels in lung, ovary, placenta and fat.
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
cGMP-PKG signaling pathway
Rap1 signaling pathway