Recombinant Mouse Vasodilator-stimulated phosphoprotein (Vasp)

1. Myocardial ischemic preconditioning-induced VASP phosphorylation in platelets is a protective mechanism against the deleterious effects of ischemia. PMID: 29344719
2. VASP selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner. PMID: 28320969
3. We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP, whereas Src-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP PMID: 26996666
4. Thus, unlike host proteins characterized in Shigella pathogenesis that promote bacterial spread, VASP and EVL function to limit it. PMID: 26358985
5. Data show that the hypoxia inducible factor 1 alpha subunit (HIF-1alpha) protein level in lung tissues increased significantly at four hours and eight hours, whereas the vasodilator-stimulated phosphoprotein (VASP) protein level decreased significantly. PMID: 25051011
6. Collectively, our studies highlighted that the CuB-induced actin aggregation and cofilin-actin rod formation was mediated via the Ga13/RhoA/PKA/VASP pathway. PMID: 24691407
7. Ena/VASP regulates mDia2-initiated filopodial morphology, dynamics, and function. PMID: 24989797
8. cancer cells reaching liver sinusoids induced up-regulation of VASP PMID: 24917558
9. Low VASP activation was associated with high fat diet (HFD). Effects of HFD on aortic inflammation and insulin resistance were recapitulated by VASP knockout, implying a role for VASP to constrain inflammatory signaling and maintain insulin sensitivity. PMID: 25117404
10. CDC42 activation inhibits this activity and promotes IRSp53-dependent recruitment and clustering of VASP to drive actin assembly. PMID: 24076653
11. VASP physically interacted with IRSp53 in NIH-Src cells and was essential for podosome formation. PMID: 23555988
12. A VASP to Rac to soluble guanylyl cyclase negative feedback loop limited cGMP production, thereby regulating adipogenesis and energy homeostasis. PMID: 22932701
13. The results of this study suggested that that PI(3,4)P2, Lpd, and Ena/VASP are involved in the process movement of multipolar migrating cells. PMID: 22915108
14. study demonstrate that endothelial VASP holds significant importance for endothelial barrier properties during hypoxia PMID: 21607702
15. studies identified VASP and VASP phosphorylation as crucial target for future hepatoprotective strategies PMID: 22216296
16. Data indicate that VASP is a critical downstream mediator of the anti-inflammatory effects induced by the NO/cGMP pathway. Targeted deletion of VASP predisposes to Kupffer cell inflammation. PMID: 21911751
17. phosphorylation of VASP by AMPK occurs at a novel site, serine 322, and phosphorylation at this site alters actin filament binding. PMID: 21945940
18. VASP binding to actin, elevated Rac activity, and elevated formation of actin free barbed ends, thus restoring normal beta(2) integrin function. PMID: 21795685
19. Growth of VASP expressing melanomas was retarded in VASP(-/-) versus wild-type animals PMID: 21762694
20. The phosphorylation of VASP performs a key function for the formation of platelet-neutrophil complexes that is crucially important for the extent of myocardial ischemia-reperfusion injury. PMID: 21606399
21. VASP is the critical regulator of BBB maintenance during acute ischemic stroke PMID: 21151938
22. VASP deficiency leads to a more profound endothelial barrier disruption and delayed recovery after activation of thrombin PAR-1 receptor. PMID: 20945373
23. A link is proposed between vimentin, VASP phosphorylation and actin dynamics that delivers an explanation for the important role of vimentin in controlling endothelial cell morphogenesis. PMID: 20382123
24. Data demonstrate a novel mechanism by which alphavbeta3 integrin acts to locally suppress beta1 integrin activation and regulate VASP and RIAM to control cell adhesion and migration. PMID: 20404115
25. VASP-deficient platelets display normal filopodia extension PMID: 19806269
26. Results suggest that VASP phosphorylation by PKA plays an important role in membrane ruffle formation and chemotaxis via the regulation of focal adhesion formation/maturation. PMID: 19733667
27. IRAK-1 forms a close complex with PKCepsilon as well as VASP, and participates in phorbol 12-myristate 13-acetate-induced phosphorylation of VASP. PMID: 20044140
28. VASP phosphorylation controls remodeling of the actin cytoskeleton. PMID: 19825941
29. These results identify tissue-specific VASP as a central protein in the control of the alveolar-capillary barrier properties during acute lung injury. PMID: 19690214
30. Results reveal a vasodilator-stimulated phosphoprotein (VASP)-dependent modulation of the Rac/PAK pathway and Rac/PAK-regulated processes, like cell motility and polarization. PMID: 12055190
31. function as a cellular regulator of actin dynamics perhaps via initializing actin polymerization PMID: 12372613
32. Ena-VASP proteins may play an important role in intercalated disk function at the interface between cardiac myocytes. PMID: 12933343
33. VASP is involved in down-regulation of platelet adhesion to the vascular wall under both physiologic and pathophysiologic conditions. PMID: 12933589
34. findings indicate that Ena/VASP proteins contribute to the persistence of both speed and directionality of L. monocytogenes movement PMID: 12940993
35. Mena & VASP are needed for viability & the formation of neural-derived organs. Neural tube, craniofacial, spinal nerve, & anterior commissure defects are seen in double but not single M-/- & V-/- mutants, showing both are needed for the above structures. PMID: 15371503
36. Despite an enhanced injury response early on, VASP -/- mice are protected from long-term progression of nephrotoxic nephritis, which is associated with improved renal endothelial cell preservation and regeneration. PMID: 15743999
37. delayed hearing development in VASP-/- mice is supposed to be caused by a delayed formation of actin filaments in the outer pillar head plate indicating the importance of appropriate pillar cell stiffness in cochlear mechanics PMID: 17361081
38. Both recruitment of SH2-Bbeta to Listeria and SH2-Bbeta stimulation of actin-based propulsion require the vasodilator-stimulated phosphoprotein (VASP), which binds ActA at the surfaces of Listeria cells and enhances bacterial actin-based motility. PMID: 17452473
39. VASP has a role during neonatal development of the mammalian cochlea PMID: 17920567
40. Loss of murine Ena/VASP protein, an actin regulatory protein, causes neuronal ectopias, alters intralayer positioning in the cortical plate, and, surprisingly, blocks axon fiber tract formation during corticogenesis. PMID: 17988629
41. VASP at least in part stabilizes endothelial barrier functions by regulating Rac1 activity. PMID: 17989211
42. VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells. PMID: 19118163
43. Data indicate that VASP is required for integrin alpha5beta1-mediated adhesion which stabilizes endothelial barrier properties at least in part by facilitating Rac 1 activation. PMID: 19347869
44. Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. PMID: 19734360
45. VASP phosphorylation at serine239 regulates cytoskeleton remodeling. PMID: 19798690

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KEGG: mmu:22323

STRING: 10090.ENSMUSP00000032561

UniGene: Mm.9684