Recombinant Mouse Zinc finger E-box-binding homeobox 1 (Zeb1), partial

1. The results suggest that the interaction between Zeb1, Hdac2, and eNOS is required for early mesendodermal differentiation of naive mouse embryonic stem cells. PMID: 29599503
2. miR-1199-5p acts in a reciprocal double-negative feedback loop with the epithelial-mesenchymal transition transcription factor Zeb1 PMID: 29079737
3. Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors. PMID: 29778661
4. NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression. PMID: 28781078
5. These data establish ZEB1 as a key factor in the tumor microenvironment and for maintaining tumor-associated macrophages' tumor-promoting functions. PMID: 29038174
6. astrocyte precursor invasion into the Zeb1(-/-) mutant white matter is delayed, and induction of their differentiation is postponed. PMID: 27806288
7. The authors report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repressing polarity genes in neuronal progenitors. PMID: 27178982
8. activation of hepatic H19RNA promoted cholestatic liver fibrosis through the ZEB1/EpCAM signaling pathway PMID: 28407375
9. Furthermore, activation of the EMT program on its own, as orchestrated by Zeb1, is sufficient to incite metastatic outgrowth by causing carcinoma cells to enter stably into a metastasis-initiating cell state. PMID: 27530323
10. Epithelial mesenchymal transformation-transcription factor Zeb1 is a key driver of pancreatic tumour progression from early tumorigenesis to late-stage metastasis, underscoring the important role of EMT activation in these processes. PMID: 28414315
11. Data suggest that, in a cell transdifferentiation system to convert mouse embryonic fibroblasts into functional neurons (transplanted into hippocampus), expression of Zeb1 is up-regulated during the early stages of transdifferentiation; knockdown of Zeb1 expression dramatically attenuates cell transdifferentiation efficiency; Zeb1 overexpression up-regulates expression of neuron-specific genes. PMID: 28500132
12. This work has established a new role for ZEB1 as an inhibitor of senescence in cancer cells, thus expanding the set of cancer cell hallmarks regulated by ZEB1. PMID: 27965283
13. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis. PMID: 26934489
14. Porphyromonas gingivalis regulates ZEB1 expression in gingival epithelial cells. PMID: 26639759
15. decrease of ZEB1 expression resulted in inhibitory effects on the B16F10 CD133+CD44+ cancer-stem-cell-like properties, and reduced the tumorigenesis and metastatic potential in the melanoma model PMID: 26559025
16. CRP suppresses expression of N-cadherin (p < 0.01), a mesenchymal marker of EMT, and ZEB-1, an EMT-related transcription factor (p < 0.01). These findings suggest that CRP inhibits EMT in a MCA-38 tumor-bearing mouse model. PMID: 25864110
17. Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism. PMID: 25643708
18. Ras induction of ZEB1 is required for tumour initiation in a lung adenocarcinoma model via Pten repression. A lower threshold of ZEB1 is sufficient for cancer initiation, whereas further induction is necessary for tumour metastasis. PMID: 25434817
19. ZEB1, an epithelial-to-mesenchymal transition activator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells. PMID: 25348003
20. uncover roles for Zeb1/2 family members in the developing Dorsal root ganglias PMID: 25942625
21. Data indicate that transcription factor ZEB1 knockdown perturbs the expression of adipogenic regulators. PMID: 25163748
22. Loss of Zeb2 in the melanocyte lineage results in a downregulation of the Microphthalmia-associated transcription factor (Mitf) and melanocyte differentiation markers concomitant with an upregulation of Zeb1. PMID: 24769727
23. ASPP2 prevents beta-catenin from transactivating ZEB1 directly by forming an ASPP2-beta-catenin-E-cadherin ternary complex PMID: 25344754
24. In culture, deltaEF1 repressed betaB1-crystallin promoter activity, suggesting that it may also turn off lens gene expression following surgery, contributing to "fibrotic Posterior capsular opacification" development. PMID: 25082886
25. Kras/Tp53-mutant lung adenocarcinoma develops metastatic disease due to high expression of ZEB1 PMID: 24762440
26. Hypoxia within spheres together with loss of Zeb1 repression synergize to cause superinduction of Hif1a, which in turn leads to induction of the DNA demethylase Aid/Aicda, demethylation of the Oct4 promoter/enhancer and multipotency. PMID: 23554223
27. Because miR-200 represses Bmi1, induction of ZEB1 leads to induction of Bmi1. Rb1 pathway status then dictates the opposing effects of mutant Ras on the ZEB1-miR-200 loop in primary versus cancer cells. PMID: 24371144
28. ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. PMID: 23340304
29. The pattern of gene expression associated with muscle differentiation is accelerated in ZEB1(-/-) mouse embryos. PMID: 23339872
30. these results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. PMID: 23765281
31. induction of ZEB1 is required for Ras-initiated tumor formation. ZEB1 is then further induced by Ras, beyond the level seen with Rb1 mutation PMID: 23443660
32. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. PMID: 22761313
33. Expression of both Zeb1 was detected in the mesenchyme of the mouse palate, while miR-200b was expressed in the medial edge epithelium. PMID: 22261924
34. Zeb1 , which were mediated by BMP4, play an important role in neural-crest-derived craniofacial organ morphogenesis, such as tooth development. PMID: 22350174
35. deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta-induced EMT and the progression of breast cancers PMID: 22037216
36. a noncoding point mutation of Zeb1 acts via a gain-of-function to disrupt regulation of Zeb1(Tw) expression, epithelial-mesenchymal cell fate or interactions, and structural development of the inner ear PMID: 21980308
37. The association of misregulation of the ZEB1/miR-200b pathway with auditory and vestibular defects in the Twirler mutant mice uncovers a novel mechanism underlying deafness and balance disorders PMID: 21980309
38. role in olfactory nerve abnormalities PMID: 11776395
39. direct binding of TMPRSS2/ERG to the promoter of ZEB1 but not ZEB2 PMID: 21747944
40. These findings implicate the miR-200 family and their targets, ZEB1 and ZEB2, as unique regulators of uterine quiescence and contractility during pregnancy and labor. PMID: 21079000
41. Decreasing ZEB1 and ZEB2 expression with shRNAs was sufficient to re-establish epithelial features. PMID: 20025777
42. dual effect of deltaEF1 in promoting breast cancer cell proliferation, by differentially regulating the cell cycle regulatory proteins. PMID: 20006705
43. The ZEB1 transcription factor regulates the accumulation of adipose tissue. PMID: 20041147
44. Result found ZEB1 to be essential for neural stem cell survival in vitro. PMID: 19785035
45. Delta-EF1 is an in vivo negative regulator of Ihh expression in the growth plate. PMID: 19948490
46. Expressed in a cell population immediately adjacent to cartilage anlagen as well as in developing tendons in embryonic limbs. PMID: 12609600
47. Embryonic gene expression of Zfhep/deltaEF1 protein in the palate and neurons of the central nervous system. PMID: 14643678
48. Data show that pro-collagen type I alpha 2 expression is activated through binding of Nkx2.5 and is repressed by the binding of deltaEF1/ZEB1 PMID: 15226419
49. deltaEF1 has a role in suppressing integrin alpha 7 expression in myoblasts by displacing MYOD and competing for p300/CBP co-activator PMID: 16129691
50. delta EF1 synergizes with FOXO transcription factors in B lymphocytes to strongly activate transcription from promoters of Ccng2 (encoding cyclin G2) and Rbl2 (p130). PMID: 16493026

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KEGG: mmu:21417

STRING: 10090.ENSMUSP00000025081

UniGene: Mm.3929