Recombinant Mouse Zinc finger protein Gfi-1 (Gfi1)

1. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. PMID: 28387757
2. AMPK was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK-Gfi1-OPN axis. PMID: 27283242
3. If Gfi1 levels fall below a threshold, Id1 expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage PMID: 27467586
4. These results clearly demonstrate that Gfi1 is a critical transcriptional regulator that controls the development of CD4pos and NK1.1pos Invariant natural killer T cells. PMID: 27284976
5. this study demonstrates the critical role of Gfi1 in the regulation of myeloid cells, and prevention of spontaneous lupus autoimmunity by negatively controlling TLR7 signaling PMID: 27600904
6. is crucial in the process of macrophage polarization, since its absence impedes macrophage polarization towards a leukemia supporting state and favors an anti-tumor state both in vitro and in vivo PMID: 27390361
7. these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1-type immune response. PMID: 26749286
8. GFI1 proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells PMID: 26619147
9. GFI1 inhibits NLRP3 inflammasome activation and IL-1beta secretion in macrophages PMID: 25447538
10. Gfi-1 is linked to the erythroid gene regulatory network by repressing Id2 expression. PMID: 25051963
11. results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer PMID: 25043047
12. Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro. PMID: 24086657
13. Our data indicate that Gfi1 is required for hematopoietic precursors to withstand Notch1 activation and to maintain Notch1 dependent transcriptional programming to determine early T-lymphoid lineage identity. PMID: 24068942
14. Data indicate that Gfi1 regulates the activation of type 2 innate lymphoid cells (ILC2 cells) cells during infection with Nippostrongylus brasiliensis. PMID: 24141388
15. Gfi1 actively controls thymocyte IL-2 production, thereby shaping thymic generation of Treg cells. PMID: 23918371
16. Compromised IL-7Ralpha expression in TGF-beta-receptor-deficient T cells was associated with increased expression of the Il7ra transcriptional repressor, Gfi-1. PMID: 23932572
17. High Gfi1 expression is associated with lymphoblastic leukemia. PMID: 23410974
18. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia characterized by a split pattern of functional responses. PMID: 22684987
19. the in vivo regulatory role of Gfi1 was specific for CD8(+), and not CD4(+) T cells or immature thymocytes. These results identify Gfi1 as a specific transcriptional repressor of the Il7r gene in CD8 T lymphocytes in vivo. PMID: 22865857
20. GFI1 and GFI1B are able to trigger, in the absence of RUNX1, the down-regulation of endothelial markers and the formation of round cells, a morphologic change characteristic of endothelial to hematopoietic transition. PMID: 22668850
21. Data suggest that Gfi1 may have an important role in prolonged multiple myeloma (MM)-induced osteoblast (OB) suppression and provide a new therapeutic target for MM bone disease. PMID: 22042697
22. Gfi1's ability to protect against apoptosis is essential for hematopoietic stem cell function. In addition, our fi nding show that Gfi1 prevents the development of myeloproliferative diseases. PMID: 21732494
23. Findings suggest that p150 may link the DNA-bound Gfi1 repressor complex to histones enabling modifications required for transcriptional silencing. PMID: 21570500
24. Data show that in in vitro endotoxin tolerant macrophages, the expression of Gfi1 mRNA and protein were up-regulated after high dose LPS stimulation, accompanied with a blunted TNF-alpha and IL-6 secretion. PMID: 20401626
25. Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development. PMID: 20453161
26. Gfi1 expression is associated with the generation of hair cells in the inner ear. PMID: 20533399
27. Data show that mucous and Paneth but not enteroendocrine lineage cells normally express Gfi1. PMID: 20599897
28. Gfi1 interacts with p65 and inhibits p65-mediated transcriptional transactivation by interfering with p65 binding to target gene promoter DNA PMID: 20547752
29. expression outside the lymphoid system in granulocytes and activated macrophages PMID: 11810106
30. Gfi1 induced by IL-4 regulates Th2 cell proliferation PMID: 12049724
31. Gfi1 is expressed in the developing nervous system, is required for inner ear hair cell differentiation, and its loss causes programmed cell death PMID: 12441305
32. Gfi-1 not only promotes differentiation of neutrophils but also antagonizes traits of the alternate monocyte/macrophage program. PMID: 12530980
33. Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. PMID: 12682108
34. role for auto- and trans-regulation of Gfi1 by GFI1 and GFI1B in maintaining the normal expression patterns of Gfi1 PMID: 15131254
35. Gfi1 is regulated through an autoregulatory feedback loop PMID: 15252036
36. Gfi1 is not expressed in the hair cells of Pou4f3 mutant deaf mice. PMID: 15254021
37. zinc-finger repressor Gfi-1 (growth factor independent 1) unexpectedly restricts proliferation of hematopoietic stem cells; Gfi-1 is essential to restrict HSC proliferation and to preserve HSC functional integrity PMID: 15457180
38. Gfi1 as a critical transcription factor that controls DC versus macrophage development and dissociates DC maturation and activation. PMID: 15963786
39. Data show that Gfi1b can replace Gfi1 functionally in haematopoiesis but not in inner ear hair cell development, demonstrating that Gfi1 and Gfi1b have equivalent and domain-dependent, cell type-specific functions. PMID: 16397623
40. Gfi-1 down-regulates C/EBPepsilon expression; increased expression of C/EBPepsilon as a consequence of loss of Gfi-1 function may be deleterious to the proliferation and survival of early myeloid cells PMID: 16500901
41. Gfi1b was found to be up-regulated in early stages of B-cell and in a subset of early T-cell development, where Gfi1 is also present, suggesting that cross-regulation of both loci exists but is cell-type specific PMID: 17095621
42. Reduced Th2 cell expansion in the absence of Gfi-1 was confirmed by the diminished frequency of IL-4-producing cells when these mice were infected with Schistosoma mansoni PMID: 17116877
43. GFI-1 represses PU.1 activity and lack of this repression in Gfi-1(-/-) myeloid cells contributes to the observed mixed lineage phenotype. PMID: 17197705
44. The modest proliferation seen in Gfi1(-/-) NE cells is consistent with the previously proposed role for Gfi1 in controlling neuroendocrine cancer growth. PMID: 17377622
45. Chromatin regulatory proteins CoREST and LSD1 mediate transcriptional repression by Gfi proteins. PMID: 17707228
46. Gfi1 functions differently in CD4+ & CD8+ T cells by maintaining different genetic programs in both cell types, & appears to be essential for the CD4 helper T cell immune response but dispensable for the function of cytotoxic CD8+ T cells. PMID: 18034420
47. a common transcriptional program that underlies both human and murine myelopoiesis, and that is central to the pathogenesis of SCN associated with mutations in GFI1. PMID: 18328744
48. Gfi1 is a regulator of the innate immune response [review] PMID: 18406379
49. a new function of Gfi1 in the control of IgG isotype production. PMID: 18991277
50. Gfi-1 plays a critical role both in enhancing Th2 cell expansion and in repressing induction of Th17 and CD103(+) iTreg cells. PMID: 19188499

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KEGG: mmu:14581

STRING: 10090.ENSMUSP00000135884

UniGene: Mm.2078