Recombinant Protein E6(E6)

Product Type Recombinant Protein
Uniprot No. P17386
Species Human papillomavirus type 31
Gene Names E6
Protein Names Recommended name: Protein E6
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Subcellular Location Host cytoplasm, Host nucleus
Protein Families Papillomaviridae E6 protein family

Product Details for Different Expression Systems

Product Name Recombinant Protein E6(E6),Yeast
Code CSB-YP322359HND
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MFKNPAERPR KLHELSSALE IPYDELRLNC VYCKGQLTET EVLDFAFTDL TIVYRDDTPH GVCTKCLRFY SKVSEFRWYR YSVYGTTLEK LTNKGICDLL IRCITCQRPL CPEEKQRHLD KKKRFHNIGG RWTGRCIACW RRPRTETQV
Expression Region 1-149
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Protein E6(E6),E.coli
Code CSB-EP322359HND
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MFKNPAERPR KLHELSSALE IPYDELRLNC VYCKGQLTET EVLDFAFTDL TIVYRDDTPH GVCTKCLRFY SKVSEFRWYR YSVYGTTLEK LTNKGICDLL IRCITCQRPL CPEEKQRHLD KKKRFHNIGG RWTGRCIACW RRPRTETQV
Expression Region 1-149
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Protein E6(E6),Baculovirus
Code CSB-BP322359HND
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MFKNPAERPR KLHELSSALE IPYDELRLNC VYCKGQLTET EVLDFAFTDL TIVYRDDTPH GVCTKCLRFY SKVSEFRWYR YSVYGTTLEK LTNKGICDLL IRCITCQRPL CPEEKQRHLD KKKRFHNIGG RWTGRCIACW RRPRTETQV
Expression Region 1-149
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Protein E6(E6),Mammalian cell
Code CSB-MP322359HND
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MFKNPAERPR KLHELSSALE IPYDELRLNC VYCKGQLTET EVLDFAFTDL TIVYRDDTPH GVCTKCLRFY SKVSEFRWYR YSVYGTTLEK LTNKGICDLL IRCITCQRPL CPEEKQRHLD KKKRFHNIGG RWTGRCIACW RRPRTETQV
Expression Region 1-149
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.