Recombinant Protein skinhead-1 (skn-1), partial

1. SKN-1 is required along with ELT-3 for the oxidative stress response. SKN-1 interacts with ELT-3. PMID: 28600327
2. DDI-1 expression is induced by proteasome dysfunction, and the authors show that DDI-1 is required to cleave and activate an endoplasmic reticulum-associated isoform of SKN-1. PMID: 27528192
3. The peptides from sesame cake (PSC) up-regulated skn-1 mRNA, and its target gene gcs-1, and abolished the extension of lifespan in skn-1 mutant, indicating that PSC-mediated longevity is dependent on activation of the skn-1/Nrf-2 transcription factor. PMID: 27381188
4. Findings show that Nrf2/skn-1 is expressed in interneurons involved in chemosensation in mice and C. elegans, and that genetic deletion of skn-1 results in impaired sensory integration. The inability to activate skn-1 signaling causes the skn-1 worms to linger in inadequate food patches rather than migrate toward new potential food sources. PMID: 28459841
5. Our data also indicate that thioallyl structure and the number of sulfur atoms are important for SKN-1 target induction. Our results indicate that SAC and SAMC may serve as potential agents that slow aging PMID: 26899496
6. SKN-1 plays a central role in diverse genetic and pharmacologic interventions that promote C. elegans longevity, suggesting that mechanisms regulated by SKN-1 may be of conserved importance in aging PMID: 26232625
7. The rpn-10 mutant animals survive through the activation of compensatory mechanisms regulated by the conserved SKN-1/Nrf2 and ELT-2/GATA transcription factors that mediate the increased expression of genes encoding proteasome subunits. PMID: 26828939
8. Data show that movements of two key arginine side chains between the major groove and the backbone of DNA generate distinct conformational sub-states that each recognize only part of the consensus binding sequence of transcription factor SKN-1. PMID: 26721385
9. The authors conclude that SKN-1 plays a direct role in maintaining lipid homeostasis in which it is activated by lipids. PMID: 26196144
10. SKN-1 and Nrf2 has a role in linking proline catabolism with lipid metabolism during nutrient deprivation PMID: 25284427
11. PTL-1 functions via neurons to modulate SKN-1, clarifying the role of this protein in the stress response and longevity. PMID: 25399685
12. A network analysis of aging-associated miRNAs connected to transcription factors PHA-4/FOXA and SKN-1/Nrf revealed extensive regulatory interactions between PHA-4, SKN-1, and miRNAs undergoing dietary restriction. PMID: 25242029
13. Anoxia results in mitochondrial oxidative stress, and the oxidative response factor SKN-1/Nrf is required for both rapid mitochondrial refusion and rapid behavioral recovery during reoxygenation PMID: 24385935
14. studies suggest that knockdown of skn-1 in the nematode increases DAergic sensitivity to MeHg exposure following a period of latency PMID: 24194349
15. our results suggest that SKN-1 activation in the nervous system can confer protection to organisms in response to stress by directly regulating nlg-1/neuroligin expression. PMID: 24453991
16. Regulatory integration through SKN-1/Nrf may coordinate ER and cytoplasmic homeostasis. PMID: 24068940
17. genetic inactivation of rict-1 suppressed skn-1-associated lethality by restoring mesendodermal specification in skn-1 deficient embryos PMID: 23973804
18. These results provide insight into how SKN-1/Nrf2 might protect the nervous system from damage in response to oxidative stress. PMID: 23555279
19. SKN-1/Nrf functions in an evolutionarily conserved pathway to modulate metabolism and adaptation to starvation. PMID: 23040073
20. Mutations in skn-1 and knockdown of genes encoding phase II detoxification enzymes led to increased sterility in the presence of dietary dihomo-gamma-linolenic acid. PMID: 23064027
21. discussion of structure and function of SKN-1 in relation to drug resistance to anthelminthic agents; includes amino acid sequence alignment/homology and phylogeny [REVIEW] PMID: 22656429
22. SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation PMID: 22568582
23. SKN-1, as a novel regulator of innate immunity, involves in immunosenescence and provides an important crosstalk between pathogenic stress signaling and the xenobiotic/oxidative stress response. PMID: 22577361
24. Mutation or silencing of WDR-46 activates the single C. elegans CnC homologue SKN-1 and increases expression of its target genes. PMID: 22240150
25. a reduction in SKN-1 gene expression increases MeHg-induced animal vulnerability and dopamine neuron degeneration. PMID: 20855423
26. SKN-1 detoxification gene network monitors various metabolic and regulatory processes. PMID: 20700440
27. the ERK (MPK-1) cascade-mediated life span extension requires SKN-1, whose function is mediated, at least partly, through DAF-2/DAF-16 insulin-like signaling. MPK-1 phosphorylates SKN-1 on the key sites that are required for SKN-1 nuclear accumulation. PMID: 20624915
28. Results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways. PMID: 20351174
29. SKN-1 represents a connection between developmental specification of the digestive system and resistance to oxidative and xenobiotic stress PMID: 12869585
30. med transcripts accumulate both in the EMS cell and in the maternal germline in a SKN-1-dependent manner PMID: 16979152
31. EEL01 controls asymmetry and persistence of Skn-1 in the early C. elegans embryo. PMID: 17537795
32. increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head PMID: 17538612
33. we have identified four kinases, MKK-4, IKK epsilon-1, NEKL-2, and PDHK-2, which are necessary for the nuclear localization of SKN-1 in response to oxidative stress PMID: 17964427
34. The findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of Insulin/IGF-1-like signaling. PMID: 18358814
35. Striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses in Caenorhabditis elegans. PMID: 19575768
36. findings showed that a transcriptional shift from growth and maintenance towards the activation of cellular defense mechanisms was caused by the oxidative stress; many of these transcriptional alterations are SKN-1 dependent. PMID: 19627265

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KEGG: cel:CELE_T19E7.2

STRING: 6239.T19E7.2a.2

UniGene: Cel.23037