Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A)

Code CSB-YP007307RB
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Source Yeast
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Code CSB-EP007307RB
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Source E.coli
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Code CSB-EP007307RB-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007307RB
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Source Baculovirus
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Code CSB-MP007307RB
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names DYRK1A
Uniprot No. P85051
Alternative Names DYRK1A; DYRKDual specificity tyrosine-phosphorylation-regulated kinase 1A; EC 2.7.12.1; Dual specificity YAK1-related kinase; Protein kinase minibrain homolog; MNBH; RP86; Fragments
Species Oryctolagus cuniculus (Rabbit)
Expression Region 1-200
Target Protein Sequence QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Subcellular Location Nucleus
Protein Families Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily

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