Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A)

Product Type Recombinant Protein
Uniprot No. P85051
Species Oryctolagus cuniculus (Rabbit)
Gene Names DYRK1A
Protein Names Recommended name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC= 2.7.12.2 Alternative name(s): Dual specificity YAK1-related kinase Protein kinase minibrain homolog Short name= MNBH RP86
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5 UTR or in the 3 coding region. These variants encode at least five different isoforms.
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Subcellular Location Nucleus
Protein Families Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily

Product Details for Different Expression Systems

Product Name Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A),Yeast
Code CSB-YP007307RB
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Expression Region 1-200
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A),E.coli
Code CSB-EP007307RB
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Expression Region 1-200
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A),Baculovirus
Code CSB-BP007307RB
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Expression Region 1-200
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A),Mammalian cell
Code CSB-MP007307RB
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Expression Region 1-200
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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