Recombinant Rat Beclin 1-associated autophagy-related key regulator(Atg14)

Product Type Recombinant Protein
Uniprot No. D4A4K3
Species Rattus norvegicus (Rat)
Gene Names Atg14
Protein Names Recommended name: Beclin 1-associated autophagy-related key regulator Short name= Barkor Alternative name(s): Autophagy-related protein 14-like protein Short name= Atg14L
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism (By similarity).
Subcellular Location Cytoplasm, Endoplasmic reticulum membrane, Peripheral membrane protein, Preautophagosomal structure membrane, Peripheral membrane protein
Protein Families ATG14 family
Database Links

KEGG: rno:305831

STRING: 10116.ENSRNOP00000016274

UniGene: Rn.47301

Pathway Autophagy

Product Details for Different Expression Systems

Product Name Recombinant Rat Beclin 1-associated autophagy-related key regulator(Atg14),Yeast
Code CSB-YP012211RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MASPSGKGSW TPEAPGFGPR ALAPDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSQLKNKQE EFQKEVLKAM EGKRLTDQLR WKIMSCKMRI EQLKQTICKG NEEMKKNSEG LLKNKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT SDLREHYDRL ACLRRLHILE LTSVIFPMDE VKTSGRDPAD VSSETDSAMT SSMVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY NWVEEKKTTQ GPDMEHNNPA YTISAALGYA TQLVNIVSHI LDINLPKKLC NSEFCGENLS KQRLTRAVRK LNANILYLCS SQHVNLDQLQ PLHTLRNLMH LVSPHSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDVSG DERVSDEETD LGTDWENLPS PRFCDIPSQP VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
Expression Region 1-492
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat Beclin 1-associated autophagy-related key regulator(Atg14),E.coli
Code CSB-EP012211RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MASPSGKGSW TPEAPGFGPR ALAPDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSQLKNKQE EFQKEVLKAM EGKRLTDQLR WKIMSCKMRI EQLKQTICKG NEEMKKNSEG LLKNKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT SDLREHYDRL ACLRRLHILE LTSVIFPMDE VKTSGRDPAD VSSETDSAMT SSMVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY NWVEEKKTTQ GPDMEHNNPA YTISAALGYA TQLVNIVSHI LDINLPKKLC NSEFCGENLS KQRLTRAVRK LNANILYLCS SQHVNLDQLQ PLHTLRNLMH LVSPHSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDVSG DERVSDEETD LGTDWENLPS PRFCDIPSQP VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
Expression Region 1-492
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Beclin 1-associated autophagy-related key regulator(Atg14),Baculovirus
Code CSB-BP012211RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MASPSGKGSW TPEAPGFGPR ALAPDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSQLKNKQE EFQKEVLKAM EGKRLTDQLR WKIMSCKMRI EQLKQTICKG NEEMKKNSEG LLKNKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT SDLREHYDRL ACLRRLHILE LTSVIFPMDE VKTSGRDPAD VSSETDSAMT SSMVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY NWVEEKKTTQ GPDMEHNNPA YTISAALGYA TQLVNIVSHI LDINLPKKLC NSEFCGENLS KQRLTRAVRK LNANILYLCS SQHVNLDQLQ PLHTLRNLMH LVSPHSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDVSG DERVSDEETD LGTDWENLPS PRFCDIPSQP VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
Expression Region 1-492
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Beclin 1-associated autophagy-related key regulator(Atg14),Mammalian cell
Code CSB-MP012211RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MASPSGKGSW TPEAPGFGPR ALAPDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSQLKNKQE EFQKEVLKAM EGKRLTDQLR WKIMSCKMRI EQLKQTICKG NEEMKKNSEG LLKNKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT SDLREHYDRL ACLRRLHILE LTSVIFPMDE VKTSGRDPAD VSSETDSAMT SSMVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY NWVEEKKTTQ GPDMEHNNPA YTISAALGYA TQLVNIVSHI LDINLPKKLC NSEFCGENLS KQRLTRAVRK LNANILYLCS SQHVNLDQLQ PLHTLRNLMH LVSPHSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDVSG DERVSDEETD LGTDWENLPS PRFCDIPSQP VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
Expression Region 1-492
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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