Recombinant Rat CD44 antigen (Cd44), partial

1. The findings indicate for the first time that regulation of Rac1 activity is responsible for hyaluronidase and CD44-driven morphological changes of astrocytes. PMID: 27163367
2. results suggest that the AT1 receptor is involved in development of hypertension and cardiac fibrosis. Selective activating ACE2/eNOS and inhibiting CD44/HA interaction might be considered as the therapeutic targets for attenuating Ang II induced deleterious cardiovascular effects PMID: 27085217
3. Results define a clinically relevant role for signaling by the hyaluronan receptor, CD44, in increased responsiveness to mechanical stimulation PMID: 26996509
4. Peptide inhibitors of CD44v6 isoforms block tumor growth and metastasis in several independent models of pancreatic cancer. PMID: 26597578
5. Expression of CD44 followed the same temporal pattern as hyaluronic acid deposition in a bladder regeneration model. PMID: 25253654
6. Results indicate a novel role for CD44 as an essential regulator of dendritic arbor complexity in both health and disease. PMID: 25300795
7. Data show that hyaluronan receptor CD44 undergoes co-internalization with hyaluronan endocytosis. PMID: 25733665
8. release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44. PMID: 23884413
9. CD44 is a key molecule in the migration of OPCs toward the focal inflammatory demyelinated lesion induced by zymosan PMID: 23280959
10. after experimental TBI, hippocampal neurons grew well on an OPN substrate with growth comparable to that seen on laminin, but showed a higher degree of primary neurites; growth on OPN was mediated through beta1 intregrins and CD44. T PMID: 22692550
11. Upregulation of hyaluronan and its binding receptors CD44 and LYVE-1 are involved in interstitial fibrosis in chronic cyclosporine-induced renal injury. PMID: 20470282
12. Results describe how CD44 regulates the motility and invasive growth of B35 neuroblastoma cells into a hyaluronan-rich environment. PMID: 20056122
13. Data show that Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity suppresses the formation or the stability of the glycocalyx, modulates ERM-related cytoskeletal interactions, and diminishes cell motility. PMID: 19783662
14. Data show that neither CD44v nor exosomes alone suffice for (pre)metastatic niche formation. PMID: 19794968
15. role of colocalization with osteopontin in migration, cell fusion, and resorption in osteoclasts PMID: 12162503
16. Data show that CD44 antigen is upregulated on all migrating cells and on newly formed blood vessels at the onset of the foreign body reaction. PMID: 12579564
17. Microarray analysis and RNA silencing link fra-1 to the expression of this antigen and c-met expresssion in mesothelioma. PMID: 12839939
18. Cd44 variant isoforms associate with tetraspanins and EpCAM. PMID: 15212938
19. Cd44 expression identifies astrocyte-restricted precursor cells. PMID: 15531362
20. The helper and cytotoxic subsets of T cells, as well as B cells, display the increased expression of CD44, intercellular adhesion molecule 1 and lymphocyte function associated antigen 1 PMID: 15624701
21. migration of rat hepatic stellate cells requires hyaluronic acid and CD44v6 PMID: 15691832
22. NCoR, GAF, and TR interact with the CD44 negative T(3)-responsive element to enhance basal transactivation, whereas T(3) induces the remodeling of chromatin structure for repression PMID: 15701601
23. role of CD44-hyaluronan interaction in mesenchymal stem cell migration in the extracellular matrix PMID: 16306150
24. CD44 is a specific marker of small hepatocytes. PMID: 16580085
25. CD44 is probably involved in early leukocyte infiltration, in tubular regeneration, and in macrophage activity in the rat kidney after ischemia/reperfusion injury. PMID: 16786159
26. The expression pattern of CD44 was studied in the rat testis following ischemia/reperfusion (I/R) injury to elucidate the possible role of the CD44 adhesion molecule in acute experimental testicular torsion. PMID: 16891795
27. The association of ezrin, radixin and moesin proteins to the coreceptor is absolutely required to mediate the hepatocyte growth factor-dependent activation of Ras by the guanine nucleotide exchange factor Sos. PMID: 17065554
28. CD44 has a pivotal role in the trans-endothelial migration of NPCs across brain endothelial cells PMID: 18450824
29. CD44-hyaluronan interaction, by enhancing biliary proliferation, may play a pathogenic role in the development of cholestatic liver diseases. PMID: 18556418
30. Data show that the rapid and transient induction of CD44 occurrs in activated microglia/macrophages following transient forebrain ischemia. PMID: 18638458
31. CD44 upregulation in neurons is affected by local chondroitin sulfate proteoglycan expression. PMID: 18694596
32. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. PMID: 19208744
33. CD44 may play an important role in the development of airway inflammatory in asthma. PMID: 19222954
34. Importantly, TSC activation upon ALS-like neurodegeneration results in significant increase in molecular proximity of CD44 and ErbB3, which may have an impact on glial plasticity at the NMJ. PMID: 19385056
35. Results suggest that Tra2beta may regulate cellular oxidative response by changing alternative splicing of distinct genes including CD44. PMID: 19439532

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UniGene: Rn.1120