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| Product Type | Recombinant Protein |
| Uniprot No. | P55213 |
| Species | Rattus norvegicus (Rat) |
| Gene Names | Casp3 |
| Protein Names | Recommended name: Caspase-3 Short name= CASP-3 EC= 3.4.22.56 Alternative name(s): Apopain Cysteine protease CPP32 Short name= CPP-32 IRP LICE Protein Yama SREBP cleavage activity 1 Short name= SCA-1 |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Target Details | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). |
| Subcellular Location | Cytoplasm |
| Protein Families | Peptidase C14A family |
| Tissue Specificity | Expressed in heart, brain, liver, and muscle but not in kidney or testis. |
| Database Links |
KEGG: rno:25402 STRING: 10116.ENSRNOP00000014096 UniGene: Rn.10562 |
| Pathway |
MAPK signaling pathway
p53 signaling pathway TNF signaling pathway Apoptosis IL-17 signaling pathway Natural killer cell mediated cytotoxicity AGE-RAGE signaling pathway in diabetic complications ER Stress pathway |
| Product Name | Recombinant Rat Caspase-3(Casp3),Yeast |
| Code | CSB-YP004548RA |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | SG IYLDSSYKMD YPEMGLCIII NNKNFHKSTG MSARNGTDVD AANLRETFMA LKYEVRNKND LTREEIMELM DSVSKEDHSK RSSFVCVILS HGDEGVIFGT NGPVDLKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETD |
| Expression Region | 29-175 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat Caspase-3(Casp3),E.coli |
| Code | CSB-EP004548RA |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | SG IYLDSSYKMD YPEMGLCIII NNKNFHKSTG MSARNGTDVD AANLRETFMA LKYEVRNKND LTREEIMELM DSVSKEDHSK RSSFVCVILS HGDEGVIFGT NGPVDLKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETD |
| Expression Region | 29-175 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat Caspase-3(Casp3),Baculovirus |
| Code | CSB-BP004548RA |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | SG IYLDSSYKMD YPEMGLCIII NNKNFHKSTG MSARNGTDVD AANLRETFMA LKYEVRNKND LTREEIMELM DSVSKEDHSK RSSFVCVILS HGDEGVIFGT NGPVDLKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETD |
| Expression Region | 29-175 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat Caspase-3(Casp3),Mammalian cell |
| Code | CSB-MP004548RA |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | SG IYLDSSYKMD YPEMGLCIII NNKNFHKSTG MSARNGTDVD AANLRETFMA LKYEVRNKND LTREEIMELM DSVSKEDHSK RSSFVCVILS HGDEGVIFGT NGPVDLKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETD |
| Expression Region | 29-175 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
Casp3 ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08857r | Rat Caspase 3,Casp-3 ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
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