Recombinant Rat Class A basic helix-loop-helix protein 15(Bhlha15)

Code CSB-YP002684RA
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Source Yeast
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Code CSB-EP002684RA
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Source E.coli
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Code CSB-EP002684RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002684RA
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Source Baculovirus
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Code CSB-MP002684RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bhlha15
Uniprot No. P70562
Alternative Names Bhlha15; Bhlhb8; Mist1Class A basic helix-loop-helix protein 15; bHLHa15; Class B basic helix-loop-helix protein 8; bHLHb8; Muscle; intestine and stomach expression 1; MIST-1
Species Rattus norvegicus (Rat)
Expression Region 1-197
Target Protein Sequence MKTKNRPPRR RTPMQDAEAT PGEQTPDRSQ SGSGASEVTK GLRSRTARAS GTRAEVSRRR QGSSSRRENS VQRRLESNER ERQRMHKLNN AFQALREVIP HVRADKKLSK IETLTLAKNY IKSLTATILT MSSSRLPGLE APGPAPGPKL YQHYHHQQQQ QQQQQQVAGA VLGVTEDQPQ GHLQRYSTQI HSFREGS
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Gene References into Functions
  1. bHLH regulate ABP in differentiated Sertoli cells. PMID: 15112319
  2. Data suggest that Mist1 activates exocrine-specific gene transcription through an acetylation mechanism. PMID: 17605298
Subcellular Location Nucleus
Tissue Specificity Expressed in liver, spleen and olfactory epithelium. Weaker expression is seen in skeletal muscle, cardiac muscle, eye and brain tissue.
Database Links

KEGG: rno:25334

STRING: 10116.ENSRNOP00000035219

UniGene: Rn.9897

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