Recombinant Rat Corticosteroid 11-beta-dehydrogenase isozyme 2 (Hsd11b2)

1. Rac1 GTPase regulates 11beta-HSD2 expression, mineralocorticoid receptor activation, and mineralocorticoid receptor-mediated pro-fibrotic signaling. PMID: 28320863
2. zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas. PMID: 26798634
3. Specific 11beta-HSD2 immunoreactivity was found in the cytoplasm of the Magnocellular Neurosecretory Cells in both the Supraoptic and Paraventricular nuclei. PMID: 26403275
4. Maternal exposure to lipopolysaccharide at later gestational ages reduced placental expression PMID: 24961461
5. 11beta-HSD2 and it's signaling factors play roles in pathogenesis of persistent pulmonary hypertension in neonatal rats. PMID: 25229964
6. Data indicate that miRNA-dependent mechanisms seem to modulate 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) dosage in health and disease states. PMID: 24980668
7. Mean methylation of the Hsd11b2 promoter in the Mg-deficient offspring (33.2%) was higher than in controls (10.4%). PMID: 21406963
8. Data show that perfluoroalkylated substances exhibit competitive inhibition of both human and rat 11beta-HSD2 activities, and suggest that perfluorooctane sulfonate is a potent endocrine disruptor for glucocorticoid metabolism. PMID: 21237268
9. lower gene and protein expression of the pre-receptor enzyme 11beta-HSD2 in IUGR animals. PMID: 20566573
10. age-related progressive decline in 11beta-HDS type 2 expression in Leydig cells PMID: 19995715
11. Data show that there is no evidence for an enhanced gene expression or activity of renal 11 beta-hydroxysteroid dehydrogenase type 2 (HSD2) in aging rats. PMID: 12059986
12. mineralocorticoid selectivity is physiologically regulated by NaCl intake at the level of 11betaHSD-2 expression and tissue distribution in the distal colon, but not in the kidney. PMID: 12842861
13. mRNA significantly rises in the left ventricle of shr rats and increase of this mRNA is one of the cause of cardiac fibrosis. PMID: 12943733
14. The vascular 11beta-HSDII level is critically important in the pathophysiology of cardiovascular disorders. PMID: 12943734
15. The stress-induced activation of 11beta-hydroxysteroid dehydrogenase 2 requireed both adrenal and extra-adrenal factors. PMID: 15156570
16. These results indicate a role for DNA methylation in 11 beta-hydroxysteroid dehydrogenase type 2 gene repression and suggest an epigenetic mechanism affecting this gene causally linked with hypertension. PMID: 15489962
17. Induction of 11beta-HSD 2 is essential for enhanced mineralocorticoid action in the remnant ileum after total colectomy in rats. PMID: 15614284
18. both types I and II 11beta HSD in Leydig cells play a protective role, opposing the adverse effects of excessive corticosterone on testosterone production. PMID: 15761036
19. increased apical targeting of ENaC subunits combined with diminished abundance of 11betaHSD2 may contribute to sodium retention associated with HgCl(2)-induced nephrotic syndrome. PMID: 16189294
20. Increased apical targeting of epithelial channel subunits subunits combined with diminished abundance of 11betaHSD2 in the kidney affects the sodium stage of liver cirrhosis. PMID: 16192424
21. lung inflammation reduces local glucocorticoid breakdown and augments glucocorticoid action in the lung by down-regulating 11beta-HSD2 via multiple mechanisms PMID: 16272800
22. data support a physiological role for hydroxysteroid 11-beta dehydrogenase 2(HSD2) regulation of glucocorticosteroid concentrations in nerve Schwann cell PMID: 16763064
23. A decreased expression of 11betaHSD2 may result in an upregulation of AQP3, in which AVP/cAMP-dependent mechanisms are unlikely to be involved. PMID: 17213730
24. Expression of Hsd11b2 by neurons in the nucleus of the solitary tract and activation of separate neurons in the parabrachial complex indicate sodium need and salt detection are both involved in the regulation of sodium appetite. PMID: 17663450
25. Prenatal exposure to nicotine elevated expression of 11-beta-HSD2 in maternal adrenals but descreased it in fetal adrenals. PMID: 17881205
26. These results demonstrated similar pattern of immunoreactivity for 11beta-HSD2 and androgen receptor in new Leydig cells population after ethane 1,2-dimethanesulphonate treatment. PMID: 18165178
27. Hence, stress-induced placental 11beta-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis. PMID: 19032587
28. Results suggest that gossypol-induced hypokalemia is likely associated with its potent inhibition of kidney 11betaHSD2. PMID: 19150652
29. LH increases the expression and enzyme activity of 11beta-HSD2, and therefore enhances capacity for oxidative inactivation of glucocorticoid in rat Leydig cells in vitro PMID: 19409113
30. myocardial remodeling induced by chronic intermittent hypoxia is associated with the up-regulation of cardiac 11HSD2. PMID: 19470702
31. Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta. PMID: 19490994
32. hsd11b2 expression marks a unique group of neurons in the brainstem (nucleus of the solitary tract) which are a)functionally aldosterone-sensitive and b) activated in association with sodium appetite. PMID: 16407537
33. Marks a unique population of mineralocorticoid receptor-expressing neurons in the brainstem (nucleus of the solitary tract) PMID: 16320254

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KEGG: rno:25117

STRING: 10116.ENSRNOP00000023130

UniGene: Rn.10186