Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1)

1. Via RNAi, it was found that ID1 induction was inhibited with silencing of HIF-1alpha. Moreover, the suppression of ID1 mRNA expression could lead to decreased expression and transcription of HIF-1alpha during hypoxia and reoxygenation. In addition, it was demonstrated that both ID1 and HIF-1alpha can regulate the transcription of twist PMID: 27127787
2. These results thus established a signaling cascade of "Abeta --> Id1 --> HIF-1 --> SHH" in primary rat cortical cultures; furthermore, SHH may in part contribute to amyloid beta neurotoxicity. PMID: 25502463
3. Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters. PMID: 25010525
4. These data suggest that BMP4 may regulate survival through the Id1/EGFR pathway during development of the rat inner ear. PMID: 23335245
5. Results suggest that the Id1/PI3K/Akt/NFkappaB/survivin signalling pathway plays a critical role in endothelial progenitor cell proliferation. PMID: 22139302
6. Recombinant human bone morphogenetic protein 2 enhanced mesenchymal stem cell Id1 expression, required for vascular differentiation and spatial organisation, under normoxic conditions. PMID: 21472453
7. Prostacyclin analogues inhibited smooth muscle cell proliferation and prevented progression of pulmonary hypertension while enhancing Smad1/5 phosphorylation and Id1 gene expression. PMID: 20522807
8. the exclusion of Id-1 from GFAP-positive cells, and expression in a population of vimentin-positive pineal astrocytes is evidence of a role for Id-1 in the adult stabilization of one form of astrocyte PMID: 12495223
9. Treatment of PC12 cells with recombinant Tat enhances the NGF-induced Id1 expression, further pointing to Id1 as a target for Tat. PMID: 15361847
10. induced in the presence of Epstein-Barr virus LMP1 and confirmed by mRNA and protein in C33A and Rat-1 cells PMID: 15564458
11. overexpression of ID1 and ID2 genes in a postmitotic, terminally differentiated cell type (Sertoli cells)have the capacity to induce reentry into the cell cycle PMID: 15647457
12. ID-1 proteins play an important role in the development of acquired drug resistance to various drugs of prostate cancer cells. (Id-1) PMID: 15809768
13. Expression of all 4 members of the Id family of transcription factors is differentially regulated in response to orchidectomy along the epididymis. PMID: 16304207
14. A 31-bp sequence (Box-2 region), located between -200 and -169bp in the Id-1 promoter is necessary for the promoter activity. PMID: 16638616
15. Drug resistant prostate cancer cells displayed significantly increased expression of ID1 compared with other prostate cancer PMID: 16728343
16. The proliferative action of Id1 on the organ of Corti is mediated by nuclear factor-kappaB (NF-kappaB) and cyclin D1 in the embryonic cochlea. PMID: 17149750

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KEGG: rno:25261

STRING: 10116.ENSRNOP00000052261

UniGene: Rn.2113