Recombinant Rat Double C2-like domain-containing protein alpha(Doc2a)

Product Type Recombinant Protein
Uniprot No. P70611
Species Rattus norvegicus (Rat)
Gene Names Doc2a
Protein Names Recommended name: Double C2-like domain-containing protein alpha Short name= Doc2-alpha
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.
HGNC 2985
RGD 620518
MGI 109446
Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells (By similarity).
Subcellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Peripheral membrane protein, Cell junction, synapse, synaptosome, Lysosome
Tissue Specificity Predominantly expressed in brain. Also found in non-neural tissues. Expressed in RBL-2H3 mast cell line.
Database Links

KEGG: rno:65031

STRING: 10116.ENSRNOP00000027022

UniGene: Rn.220257

Product Details for Different Expression Systems

Product Name Recombinant Rat Double C2-like domain-containing protein alpha(Doc2a),Yeast
Code CSB-YP007091RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MRGRRGDRMT INIQEHMAIN VCPGPIRPIR QISDYFPRRG PGPEGGGGGR GFGEAPAHLA PLALAPPAAL LGATTPDDGA EVDSYDSDDT TALGTLEFDL LYDQASCMLH CRILRAKGLK PMDFNGLADP YVKLHLLPGA CKANKLKTKT QRNTLNPVWN EELTYSGITD DDITHKVLRI SVCDEDKLSH NEFIGEIRVP LRRLKPSQKK HFNICLERQV PLPSPSSMSA ALRGISCYLK ELEQAEQGPG LLEERGRILL SLSYSSRRHG LLVGIVRCAH LAAMDVNGYS DPYVKTYLRP DVDKKSKHKT CVKKKTLNPE FNEEFFYEME LSTLATKTLE VTVWDYDIGK SNDFIGGVSL GPGARGEAQK HWRDCLHQPD TAVERWHTLT SELPPAAGAL PLA
Expression Region 1-403
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat Double C2-like domain-containing protein alpha(Doc2a),E.coli
Code CSB-EP007091RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MRGRRGDRMT INIQEHMAIN VCPGPIRPIR QISDYFPRRG PGPEGGGGGR GFGEAPAHLA PLALAPPAAL LGATTPDDGA EVDSYDSDDT TALGTLEFDL LYDQASCMLH CRILRAKGLK PMDFNGLADP YVKLHLLPGA CKANKLKTKT QRNTLNPVWN EELTYSGITD DDITHKVLRI SVCDEDKLSH NEFIGEIRVP LRRLKPSQKK HFNICLERQV PLPSPSSMSA ALRGISCYLK ELEQAEQGPG LLEERGRILL SLSYSSRRHG LLVGIVRCAH LAAMDVNGYS DPYVKTYLRP DVDKKSKHKT CVKKKTLNPE FNEEFFYEME LSTLATKTLE VTVWDYDIGK SNDFIGGVSL GPGARGEAQK HWRDCLHQPD TAVERWHTLT SELPPAAGAL PLA
Expression Region 1-403
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Double C2-like domain-containing protein alpha(Doc2a),Baculovirus
Code CSB-BP007091RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MRGRRGDRMT INIQEHMAIN VCPGPIRPIR QISDYFPRRG PGPEGGGGGR GFGEAPAHLA PLALAPPAAL LGATTPDDGA EVDSYDSDDT TALGTLEFDL LYDQASCMLH CRILRAKGLK PMDFNGLADP YVKLHLLPGA CKANKLKTKT QRNTLNPVWN EELTYSGITD DDITHKVLRI SVCDEDKLSH NEFIGEIRVP LRRLKPSQKK HFNICLERQV PLPSPSSMSA ALRGISCYLK ELEQAEQGPG LLEERGRILL SLSYSSRRHG LLVGIVRCAH LAAMDVNGYS DPYVKTYLRP DVDKKSKHKT CVKKKTLNPE FNEEFFYEME LSTLATKTLE VTVWDYDIGK SNDFIGGVSL GPGARGEAQK HWRDCLHQPD TAVERWHTLT SELPPAAGAL PLA
Expression Region 1-403
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Double C2-like domain-containing protein alpha(Doc2a),Mammalian cell
Code CSB-MP007091RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MRGRRGDRMT INIQEHMAIN VCPGPIRPIR QISDYFPRRG PGPEGGGGGR GFGEAPAHLA PLALAPPAAL LGATTPDDGA EVDSYDSDDT TALGTLEFDL LYDQASCMLH CRILRAKGLK PMDFNGLADP YVKLHLLPGA CKANKLKTKT QRNTLNPVWN EELTYSGITD DDITHKVLRI SVCDEDKLSH NEFIGEIRVP LRRLKPSQKK HFNICLERQV PLPSPSSMSA ALRGISCYLK ELEQAEQGPG LLEERGRILL SLSYSSRRHG LLVGIVRCAH LAAMDVNGYS DPYVKTYLRP DVDKKSKHKT CVKKKTLNPE FNEEFFYEME LSTLATKTLE VTVWDYDIGK SNDFIGGVSL GPGARGEAQK HWRDCLHQPD TAVERWHTLT SELPPAAGAL PLA
Expression Region 1-403
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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