Recombinant Rat Endothelial PAS domain-containing protein 1 (Epas1), partial

1. Over-expressed lenti-EPAS1 can promote angiogenesis via the up-regulation of EPAS1-related angiogenic factors in the muscles of the affected hind limb and reduce gait disturbance. PMID: 29268860
2. HIF-1alpha to HIF-2alpha switch in glycolytic gastrocnemius muscle in chronic kidney disease might be a protective mechanism against tissue hypoxia and oxidative stress. PMID: 28820398
3. ZnCl2 (10 mg/kg) significantly lowered the creatinine and urea concentrations compared to saline-treated control rats following a clinically relevant 60 minutes of ischemia. Zn2+ induced expression of HIF1a and HIF2a but not HIF3a.ZnCl2 preconditioning protects against renal Ischemia-reperfusion injury in a dose-dependent manner PMID: 28686686
4. Thirty-five days of chronic intermittent hypoxia up-regulated HIF-1alpha in the liver and down-regulated HIF-1alpha and HIF-2alpha in skeletal muscle. We concluded that the effect of chronic intermittent hypoxia on insulin sensitivity and signaling is time-dependent and is associated with changes in HIF signaling in insulin-sensitive tissues. PMID: 26993367
5. Demonstrate that iron deficiency augments megakaryocytic differentiation and proplatelet formation and suggest a potential role of HIF2alpha in megakaryopoiesis. PMID: 25715026
6. Results showed that the inhibitory effects of TNFa on the hypoxia-induced upregulation of erythropoietin expression are mediated primarily by HIF-2a rather than HIF-1a PMID: 25283246
7. HIF-2a accumulates earlier than Hif1a in bladder outlet obstruction PMID: 24589856
8. This investigation has thus revealed a novel aspect of Atp7a gene regulation in which Sp1 may be necessary for the HIF-mediated induction of gene transcription during iron deficiency/hypoxia. PMID: 23814049
9. inhibition of HIF-1/2alpha did not reverse the effects of hypoxia on IL-6 gene expression. In addition, phosphorylation of p38, but not JNK, was responsible for the effects of glucose deprivation on IL-6 gene expression. PMID: 23520526
10. In chronically hypoxic PC12 cells glycolytic energy budget, increased energy preservation and low susceptibility to OGD are observed. HIF-2alpha no longer orchestrates adaptive responses to anoxia. PMID: 23462283
11. Oxidative stress triggers increased HIF-1alpha protein levels in HIF-2alpha-deficient PC12 cells. PMID: 23610397
12. Rgs4 transcript is readily detected but does not respond to hypoxia. Furthermore, this regulation was found to be dependent on transcription, and occurs in a manner consistent with direct HIF transactivation of Rgs4 transcription PMID: 22970249
13. Uppregulation of both HIF-2alpha and Kir6.2 is confined to medullary, but not cortical, tissue in adrenal chromaffin cells following prenatal nicotine exposure. PMID: 22403787
14. In nucleus pulposus cells, HIF-1alpha and HIF-2alpha, degradation was mediated through 26S proteasome irrespective of oxygen tension. PMID: 21987385
15. Glucose-induced O consumption creates an intracellular hypoxia that activates HIF1 and HIF2 in rat beta-cells PMID: 22235342
16. HIF-1alpha and HIF-2alpha signaling and oxygen tension at the surface of cells were important in regulating the phenotype of rat alveolar type II cells. PMID: 21454802
17. These results suggest that the translation of HIF-2alpha in the liver is regulated in part by the action of iron regulatory proteins in response to dietary iron deficiency. PMID: 21753061
18. in b/b rats depressed liver hepcidin production and activated intestinal Hif2alpha starting at the C-pole resulted in increasing expression of iron transport genes, including DMT1 G185R, in an attempt to compensate for the anemia in Belgrade rats. PMID: 21436314
19. Data show that the Atp7a gene is upregulated by direct interaction with HIF2alpha, demonstrating coordinate regulation with genes related to intestinal iron homeostasis. PMID: 21346155
20. Suggest that increased vein wall tension induces HIF overexpression and causes an increase in MMP expression and reduction of venous contraction, leading to progressive venous dilation and varicose vein formation. PMID: 21106323
21. The differential expression of HIF1a, HIF2a, and HIF3a may play a role in the development of hypoxia-induced pulmonary hypertension. PMID: 16677454
22. retinal HIF-1alpha and HIF-2alpha were not found to be increased, and the extent of hypoxia may even decrease after 12 weeks of hyperglycemia in rats. PMID: 20005221
23. rat pheochromocytoma PC12 cells, nerve growth factor (NGF) stimulation results in a decrease of both basal and hypoxia-induced levels of HIF-2 alpha protein. NGF treatment did not increase HIF-hydroxylase gene expression or activity, and the reduction of PMID: 12805361
24. identified many novel HIF regulated genes with diverse functions in hypoxia mediated signaling and survival pathways PMID: 14747751
25. Marked nuclear accumulation of HIF-1alpha and -2alpha occurred after both systemic hypoxia and coronary ligation in cardiomyocytes as well as interstitial and endothelial cells (EC) without pronounced changes in HIF mRNA levels PMID: 15247145
26. HIF-1alpha, HIF-2alpha and HIF-3alpha may not only confer different target genes, but also play key pathogenetic roles in hypoxic-induced pulmonary hypertension. PMID: 16215633
27. Hypoxia stimulates translation of HIF-1alpha and -2alpha proteins by distributing their mRNAs to larger polysome fractions. This requires influx of extracellular calcium, stimulation of classical protein kinase C-alpha, & mTOR activity. PMID: 16507764
28. expression in the carotid body during chronic hypoxia PMID: 16683694
29. hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment are regulated in a cell-specific manner PMID: 16760477
30. HIF-alpha subunits and prolyl hydroxylases show differential and reciprocal regulation, which might play a key pathogenesis role in hypoxia-induced pulmonary hypertension PMID: 16761101
31. HIF2alpha C-terminal transactivation domain, in contrast to the HIF1alpha C-terminal transactivation domain, is relatively resistant to the inhibitory effects of FIH1 under normoxic conditions PMID: 17220275
32. Activation of HIF-1alpha and HIF-2alpha contributes significantly to stretch- but not to shear-stress-induced capillary growth. PMID: 17627993
33. In O2-sensitive adrenomedullary chromaffin cells mitochondrial O2 consumption regulates HIF-2alpha during hypoxia. PMID: 18353899
34. HIF-1alpha/-2alpha had distinct spatial expression patterns in rat model of ischemic heart disease. Both HIF subunits might be potent stimuli for cardiomyocytes to re-enter the cell cycle and initiate DNA synthesis. PMID: 18484163
35. Activation of hypoxia-inducible factors (HIF-1a and HIF-2a) ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. PMID: 18515655
36. HIF-2 and HIF-1 modulate their own transcriptional activity through cited2 in nucleus pulposis PMID: 19035510
37. Intermittent hypoxia leads to down-regulation of HIF-2alpha via a calpain-dependent signaling pathway and results in oxidative stress as well as autonomic morbidities. PMID: 19147445
38. Report increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. PMID: 19420289
39. A basal level of HIF-2alpha is required for normal developmental expression of DOPA decarboxylase and dopamine beta hydroxylase; loss of this function leads to impaired catecholamine biosynthesis. PMID: 19457096
40. adaptation to hypoxia exerts a protective role on cardiomyocytes subjected to ischemia and that, unexpectedly, this form of preconditioning absolutely depends on Hif-2alpha. PMID: 19461047

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KEGG: rno:29452

STRING: 10116.ENSRNOP00000033874

UniGene: Rn.163791