Recombinant Rat Epoxide hydrolase 2(Ephx2)

Code CSB-YP007735RA
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Source Yeast
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Code CSB-EP007735RA
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Source E.coli
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Code CSB-EP007735RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007735RA
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Source Baculovirus
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Code CSB-MP007735RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ephx2
Uniprot No. P80299
Alternative Names Ephx2; Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2; CEH; EC 3.3.2.10; Epoxide hydratase; Soluble epoxide hydrolase; SEH); Lipid-phosphate phosphatase; EC 3.1.3.76)]
Species Rattus norvegicus (Rat)
Expression Region 1-554
Target Protein Sequence MALRVAAFDL DGVLALPSIA GVLRHTEEAL ALPRDFLLGA FQMKFPEGPT EQLMKGKITF SQWVPLMDES CRKSSKACGA SLPENFSISE IFSQAMAARS INRPMLQAAA ALKKKGFTTC IVTNNWLDDS DKRDILAQMM CELSQHFDFL IESCQVGMIK PEPQIYKFVL DTLKAKPNEV VFLDDFGSNL KPARDMGMVT ILVRDTASAL RELEKVTGTQ FPEAPLPVPC SPNDVSHGYV TVKPGIRLHF VEMGSGPAIC LCHGFPESWF SWRYQIPALA QAGFRVLAID MKGYGDSSSP PEIEEYAMEL LCEEMVTFLN KLGIPQAVFI GHDWAGVLVW NMALFHPERV RAVASLNTPL MPPNPEVSPM EVIRSIPVFN YQLYFQEPGV AEAELEKNMS RTFKSFFRTS DDMGLLTVNK ATEMGGILVG TPEDPKVSKI TTEEEIEYYI QQFKKSGFRG PLNWYRNTER NWKWSCKALG RKILVPALMV TAEKDIVLRP EMSKNMENWI PFLKRGHIED CGHWTQIEKP AEVNQILIKW LKTEIQNPSV TSKI
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Bifunctional enzyme
Gene References into Functions
  1. Data suggest that significant dietary potassium (here, even as a single meal) increases postprandial effects that reduce sEH activity in blood by mechanisms involving insulin secretion and gut microbiota; these mechanisms combat oxidative stress and prevent cardiovascular diseases. PMID: 28863368
  2. Prophylactic treatment with sEH inhibitors decreased myocardial damage due to ischemia reperfusion, hypertension and diabetes, and decreased endothelial dysfunction created by diabetes and hypertension. PMID: 28296232
  3. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PMID: 25659109
  4. The results suggest Ephx2 participation in the control of the vascular tone changes in kidney promoting the hypertensive state in the ISIAH rats. PMID: 25509856
  5. Soluble epoxide hydrolase probably plays an important role in the development of hypertension in the rat models of renovascular hypertension. The activation of PPAR-gamma and RAAS by renal arterial stenosis are associated with sEH upregulation. PMID: 22178827
  6. Inhibition of soluble epoxide hydrolase slows the progression of hyperglycemia and provides cardioprotection. PMID: 22865388
  7. Programmed blood pressure-lowering effects of perinatal SEH inhibition cannot be only explained by persistent reduction in renal SEH activity but rather by more complex interactions between the renal SEH, lipoxygenase, and cyclooxygenase pathways. PMID: 21266668
  8. Epoxide hydrolase inhibitors displays antihypertensive effects in Ren-2 transgenic rats with inducible malignant hypertension via an improvement of renal function. PMID: 21078594
  9. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. PMID: 21164107
  10. Soluble epoxide hydrolase enzyme (SEH) inhibition or Ephx2 gene deletion antagonizes neointimal formation in vivo by mechanisms that are endothelium dependent. SEH inhibition may have therapeutic potential for flow-induced remodeling. PMID: 20035028
  11. Epoxide hydrolase plays a role in the regulation of blood pressure PMID: 11882632
  12. Polymorphism in Ephx2 is not likely to contribute to blood pressure levels in spontaneously hypertensive rats. PMID: 12364351
  13. AP-1 activation is involved in the transcriptional up-regulation of sEH by angiotensin II (Ang II) in endothelial cells, which may contribute to Ang II-induced hypertension PMID: 17495027
  14. Linkage analyses with genome-wide expression profiling identified Ephx2 as a heart failure susceptibility gene in SHHF rats. PMID: 18443590
  15. protein level of sEH was elevated in the heart of both spontaneously hypertensive rats and Ang II-infused Wistar rats PMID: 19126686

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Subcellular Location Cytoplasm, Peroxisome
Protein Families AB hydrolase superfamily, Epoxide hydrolase family
Database Links

KEGG: rno:65030

STRING: 10116.ENSRNOP00000023385

UniGene: Rn.54495

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