Recombinant Rat Fibroblast growth factor 1 (Fgf1)

1. FGF1-overexpressed adipose-derived mesenchymal stem induce neuroprotection and functional recovery in a rat stroke model. PMID: 28795363
2. Suboptimal FGFR activation by a weak FGF1-FGFR dimer is sufficient to evoke a metabolic response, whereas full FGFR activation by stable and sustained dimerization is required to elicit a mitogenic response. PMID: 28813681
3. This is the first time a comprehensive subset of proteins involved in FGF inhibitory response is defined. We were able to identify a number of targets and specifically discover glycogen synthase kinase3beta (GSK3beta) as a novel key mediator of FGF inhibitory response in chondrocytes. PMID: 28298517
4. FGF-1 may have preventative and therapeutic effects on TGF-beta1-driven pulmonary fibrosis via inhibiting myofibroblast differentiation, inducing AEC proliferation, regulating TGF-beta1 signalling by controlling TGFbetaR1 expression and degradation, and regulating FGFR1 expression. PMID: 27425145
5. Results show that phosphorylation does not regulate FGF1 neurotrophic activity but inhibits its anti-apoptotic activity after p53-dependent apoptosis induction, giving new insight into the poorly described FGF1 intracrine/nuclear pathway. PMID: 26844696
6. FGF1 is secreted during prolonged activation of cultured beta-cells and that endoplasmic reticulum stress acts upstream of FGF1 release. PMID: 26420862
7. Study presents a transcript profiling of remyelinated multiple sclerosis lesions and identified FGF1 as a promoter of remyelination PMID: 25589163
8. Fibroblast growth factor 1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding with retinoblastoma-like 1 (p107) dephosphorylation. PMID: 23775125
9. Only the B55alpha(55-kDa regulatory subunit, alpha isoform) regulatory subunit of PP2A was able to bind retinoblastoma-like 1 (p107), and this interaction was induced by fibroblast growth factor 1 in chondrocytes but not in other cell types. PMID: 23716589
10. FGF-1 and FGF-2 expression are enhanced in the infarcted myocardium in the early stage after myocardial infarction. PMID: 20674996
11. the activation of FRS2alpha by FGL was significantly lower than the activation by FGF1, indicating a differential signaling profile induced by NCAM compared with the cognate growth factor PMID: 20175207
12. The FGF-1 system of the ventral tegmental area is required for biochemical and behavioral sensitization to morphine. PMID: 19819303
13. the neuroprotective effects of FGF1 involve inactivation of GSK3beta PMID: 12095987
14. FN and FGF act in concert to regulate cell differentiation in the nervous system. PMID: 12127979
15. Endothelin A receptor in pulmonary arterial smooth muscle cells is unresponsive to hypoxia but is robustly stimulated by tyrosine kinase receptor-associated growth factors (FGF-1, FGF-2, PDGF-BB) that themselves are stimulated by hypoxia in lung. PMID: 12851419
16. FGF-1 synthesis is essentially upregulated by Ca(2+) influx through excitatory neuronal activities, but such an effect is abolished by neurotransmission that evokes cAMP/PKA signals PMID: 15264218
17. Fibroblast growth factor 1 is produced prior to apolipoprotein E in the astrocytes after cryo-injury of mouse brain PMID: 15627653
18. When rat apoE/pcDNA3.his was transfected to transformed rat astrocyte GA-1 cells that otherwise do not synthesize apoE (GA-1/25), FGF-1 did not influence apoE-mRNA, but did increase the apoE secretion & Akt phosphorylation that were suppressed by LY294002 PMID: 17548887
19. parasympathetic preganglionic neurons are largely devoid of FGF1, which is a unique feature among cholinergic neurons PMID: 17701912
20. The degeneration of nigral dopamine neurons, confirmed by the disappearance of FGF-1 mRNA and the decrement of tyrosine hydroxylase mRNA labeled nigral neurons, was not altered by adrenalectomy. PMID: 18086466
21. analyisis of gene exprsesion during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells PMID: 18189245
22. Sustained delivery of Fgf1 increases vascular density in comparison to bolus administration. PMID: 19555698
23. FGF1 nuclear translocation is required for both its neurotrophic activity and its p53-dependent apoptosis protection. PMID: 19765618

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KEGG: rno:25317

STRING: 10116.ENSRNOP00000018577

UniGene: Rn.88013