Recombinant Rat G protein-coupled receptor kinase 4(Grk4)

Product Type Recombinant Protein
Uniprot No. P70507
Species Rattus norvegicus (Rat)
Gene Names Grk4
Protein Names Recommended name: G protein-coupled receptor kinase 4 EC= 2.7.11.16 Alternative name(s): G protein-coupled receptor kinase GRK4
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. Plays an important role in the regulation of renal sodium handling and blood pressure.
Subcellular Location Cytoplasm, Cytoplasm, cell cortex
Protein Families Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
Tissue Specificity Isoform GRK4A is expressed in testis. Isoform GRK4B is heterogeneously distributed in the kidney, with 20-fold enrichment in the outer medulla. Has a widespread but low level of expression in tissues other than testis.
Database Links

KEGG: rno:59077

STRING: 10116.ENSRNOP00000015894

UniGene: Rn.54517

Pathway Chemokine signaling pathway
Endocytosis

Product Details for Different Expression Systems

Product Name Recombinant Rat G protein-coupled receptor kinase 4(Grk4),Yeast
Code CSB-YP009925RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH
Expression Region 1-575
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat G protein-coupled receptor kinase 4(Grk4),E.coli
Code CSB-EP009925RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH
Expression Region 1-575
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat G protein-coupled receptor kinase 4(Grk4),Baculovirus
Code CSB-BP009925RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH
Expression Region 1-575
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat G protein-coupled receptor kinase 4(Grk4),Mammalian cell
Code CSB-MP009925RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH
Expression Region 1-575
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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