Recombinant Rat GTP cyclohydrolase 1 feedback regulatory protein(Gchfr)

Product Type Recombinant Protein
Uniprot No. P70552
Species Rattus norvegicus (Rat)
Gene Names Gchfr
Protein Names Recommended name: GTP cyclohydrolase 1 feedback regulatory protein Short name= GFRP Alternative name(s): GTP cyclohydrolase I feedback regulatory protein p35
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Function Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Subcellular Location Nucleus, Nucleus membrane, Cytoplasm, cytosol
Protein Families GFRP family
Tissue Specificity Liver and kidney. Somewhat lower level in testis, heart, brain and lung.
Database Links

KEGG: rno:171128

STRING: 10116.ENSRNOP00000016458

UniGene: Rn.11137

Product Details for Different Expression Systems

Product Name Recombinant Rat GTP cyclohydrolase 1 feedback regulatory protein(Gchfr),Yeast
Code CSB-YP009318RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence PYLLISTQI RMEVGPTMVG DEHSDPELMQ QLGASKRRVL GNNFYEYYVN DPPRIVLDKL ECRGFRVLSM TGVGQTLVWC LHKE
Expression Region 2-84
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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Product Name Recombinant Rat GTP cyclohydrolase 1 feedback regulatory protein(Gchfr),E.coli
Code CSB-EP009318RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence PYLLISTQI RMEVGPTMVG DEHSDPELMQ QLGASKRRVL GNNFYEYYVN DPPRIVLDKL ECRGFRVLSM TGVGQTLVWC LHKE
Expression Region 2-84
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat GTP cyclohydrolase 1 feedback regulatory protein(Gchfr),Baculovirus
Code CSB-BP009318RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence PYLLISTQI RMEVGPTMVG DEHSDPELMQ QLGASKRRVL GNNFYEYYVN DPPRIVLDKL ECRGFRVLSM TGVGQTLVWC LHKE
Expression Region 2-84
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat GTP cyclohydrolase 1 feedback regulatory protein(Gchfr),Mammalian cell
Code CSB-MP009318RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence PYLLISTQI RMEVGPTMVG DEHSDPELMQ QLGASKRRVL GNNFYEYYVN DPPRIVLDKL ECRGFRVLSM TGVGQTLVWC LHKE
Expression Region 2-84
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat

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