Recombinant Rat Gamma-aminobutyric acid receptor subunit beta-2 (Gabrb2), partial

1. the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions. PMID: 27382064
2. The data of this study reveal that GABAA receptor beta2 and beta3 decrease following 1 h of acute restraint stress and may play a critical role in stress-induced hyperalgesia. PMID: 24992900
3. These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops. PMID: 23205938
4. The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the alpha(1)beta(2)gamma(2)L receptor. PMID: 21474657
5. Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors. PMID: 20937799
6. Results indicate that beta2 Loop 9 is involved in receptor activation by GABA, propofol, and pregnanolone and that beta2(Q185) participates in hydrophilic interactions that are important for stabilizing the closed state of the GABA(A) receptor. PMID: 20007704
7. The magnitude of GABA(A) receptor beta 2 subunit mRNA expression in rat telencephalic neuronal populations is found to be inferior to that of the distantly related hedgehog. PMID: 11845246
8. TM1 glycine on the beta2 subunit is involved with desensitization of GABA-,pentobarbital-, and propofol-induced currents PMID: 11877425
9. analysis of the role of a single M1 residue in the beta2 subunit of GABAA receptor alters channel gating of GABAA receptor in anesthetic modulation and direct activation PMID: 12939268
10. identified a number of highly conserved charged residues in the GABAA-R beta2 subunit that appear to be involved in receptor activation PMID: 14610076
11. GABA(B2) subunit mRNAs were were first weakly detected on GD 13.5. On GD 15.5, 17.5, and 19.5, these subunit mRNAs were found in the retina, hippocampus, cerebral cortex, spinal cord, and cerebellum area. PMID: 15158077
12. Slow GABA-A receptor kinetics are not governed by simple ligand-receptor interactions. Access to the steroid direct gating (and perhaps potentiation) site occurs via the plasma membrane & the membrane concentration of steroid governs direct gating. PMID: 15282269
13. To elucidate the role of the beta2Ile154-Asp163 region in GABA(A)R activation, each residue was individually mutated to cysteine and coexpressed with wild-type alpha1 subunits in Xenopus laevis oocytes. PMID: 15601928
14. A gate exists between the picrotoxin binding site and the channel's extracellular end, consistent with a closed channel gate in the middle of the channel. PMID: 17227918
15. Tonic activation of GABA-A receptors in developing hippocampus enhances glutamergic cell excitability and synaptic activity. PMID: 17317750
16. alpha6-beta2-delta GABA A receptors exist in high/low affinity states and expression of subunits alters equilibrium between the two states. PMID: 17395622
17. Using wild type/mutated receptor subunits to identify compounds with anesthetic effect. PMID: 18292428
18. Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. PMID: 18387955
19. Intriguingly, although there is no direct interaction between GISP and the GABA(B2) subunit, their co-expression in HEK293 cells increases levels of GABA(B2). PMID: 18643869

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KEGG: rno:25451

STRING: 10116.ENSRNOP00000004970

UniGene: Rn.207158