Recombinant Rat Metallothionein-2(Mt2)

Code CSB-YP356242RA
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Source Yeast
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Code CSB-EP356242RA
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Source E.coli
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Code CSB-EP356242RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP356242RA
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Source Baculovirus
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Code CSB-MP356242RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Mt2
Uniprot No. P04355
Alternative Names Mt2; Metallothionein-2; MT-2; Metallothionein-II; MT-II
Species Rattus norvegicus (Rat)
Expression Region 1-61
Target Protein Sequence MDPNCSCATD GSCSCAGSCK CKQCKCTSCK KSCCSCCPVG CAKCSQGCIC KEASDKCSCC A
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Gene References into Functions
  1. acute attack of experimental autoimmune encephalomyelitis was followed by increased expression of metallothioneins in molecular and granular cell layer of hippocampus. PMID: 27173051
  2. observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, returning to the levels measured in adolescent rats PMID: 27939232
  3. MT-I/II are required for the conditioning lesion effect and can promote axonal regeneration in the injured central nervous system. PMID: 25947372
  4. endogenous MT-I/II might play an important role in the pathogenesis of pain behaviors, participating in the initiation of inflammatory and neuropathic pain rather than in their maintenance PMID: 23726995
  5. Metallothionein-2 expression is regulated by psychological stress in adult male and female rats. PMID: 23291980
  6. Zinc pre-treatment improved MT-1 and MT-2 gene expressions in kidney which significantly alleviated acute toxicity of depleted uranium. PMID: 22703381
  7. The MT mRNA level displays isoform-specific changes: those of MT-1 do not change appreciably, whereas those of MT-2 increase significantly in 2-hr endotoxemia, with or without obstructive jaundice. PMID: 22100509
  8. Expression of MT2 in the adult rat testes and during development PMID: 20109269
  9. The solution structures of Cd(3)-thiolate cluster containing beta-domain of mouse beta-MT-1 and rat beta-MT-2 show high structural similarities, but widely differing structure dynamics. PMID: 19609577
  10. Results provide evidence for the heterogeneous distribution of MT(2) receptors in different parts and layers of the gastrointestinal tract, which could indicate a physiological role of melatonin in the gastrointestinal tract. PMID: 19004484
  11. TTR-MT1/2 complexes may be functionally significant not only in healthy conditions but also in Abeta deposition in Alzheimer disease. PMID: 18237193

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Protein Families Metallothionein superfamily, Type 1 family
Database Links

KEGG: rno:689415

STRING: 10116.ENSRNOP00000062585

UniGene: Rn.115549

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