Recombinant Rat Mitogen-activated protein kinase 3 (Mapk3)

1. Retinoic acid was also found to rapidly downregulate extracellular signal-regulated kinase (ERK) 1/2 phosphorylation. PMID: 29520716
2. Angiostrongylus cantonensis-conditioned culture medium induced suppression of the Erk1/2-NF-kappaB signaling pathway leading to reduced MBP production in RSC96 Schwann cells. PMID: 29742816
3. Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction. PMID: 29901080
4. Signal communication between neurons and satellite glial cells expands the duration of neuronal ERK1/2 phosphorylation and pain hypersensitivity at 1 h after tissue injury. PMID: 29592783
5. The experimental results demonstrated that there was a coexistence of GRs and pERK 1/2 in the spinal cord dorsal horn by double immunofluorescence staining. The GR antagonist RU38486 attenuated the morphine analgesia tolerance by inhibiting the expression of GR and increasing the expression of pERK. PMID: 29845273
6. miRNA-15b deteriorates cardiomyocyte apoptosis by post-transcriptionally downregulating the expression of Bcl-2 and MAPK3. PMID: 28814571
7. ERK1/2 and Akt phosphorylation were essential for mechano-growth factor E peptide regulating cell morphology and mobility but not proangiogenic capacity of bone marrow-derived mesenchymal stem cells under severe hypoxia PMID: 29441602
8. Study shows that the mitogen-activated protein kinase pathway is involved in promoting the sodium appetite after low-sodium diet consumption. PMID: 28836382
9. Homocysteine up-regulates ETA receptor expression via the Sirt1/ERK1/2 signaling pathway in vascular smooth muscle cells. PMID: 28579512
10. Study demonstrated that blockade of audiogenic seizure (AGS) by inactivation of ERK1/2 inhibits Synapsin I activity and glutamate release in the striatum, decreases the activity of dopaminergic neurons, and leads to upregulation of GABA synthesis in the substantia nigra; suggests that nigrastriatal system may be involved in or affected by the AGS expression in Krushinsky-Molodkina rats. PMID: 28738742
11. Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway. PMID: 28758954
12. Phosphorylated extracellular signal-regulated kinase 1/2 blockade in the Locus Coeruleus relieved anxiety and counteracted altered Locus Coeruleus function; authors propose that phosphorylated extracellular signal-regulated kinase 1/2 activation in the Locus Coeruleus plays a crucial role in pain-related anxiety. PMID: 28158734
13. Apocynin may act as a novel molecular candidate to protect against vascular smooth muscle cell osteogenic switching/vascular calcification through suppressing ERK1/2 pathway. PMID: 27835878
14. miR-15b-5p might inhibit cell proliferation and induce apoptosis in PC12 cells by targeting ERK1 expression. PMID: 28609839
15. Late pregnancy is a critical period for changes in phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 in oxytocin neurones. Results suggest an important role for the MAPK/ERK pathway during reproductive changes in the supraoptic and paraventricular nucleus. PMID: 27203238
16. EMF-induced cyclic adenosine monophosphate (cAMP) level increase causes protein kinase A (PKA) and extracellular signal-regulated kinase (ERK)1/2 phosphorylation. PMID: 24634418
17. ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development PMID: 29101749
18. DOX induced mitochondrial ROS release to activate ERK1/2-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo. PMID: 28295305
19. CTRP9 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and migration via TGF-beta1/ERK1/ERK2 signaling pathway. PMID: 28688765
20. Inhibiting miR-21 attenuates hepatic fibrosis by suppressing both the ERK1 in hepatic stellate cells and epithelial-mesenchymal transition of hepatocyte. PMID: 27226339
21. Astrocytes can cause Ca(2+) signaling activation, ERK1/2 phosphorylation, and Id4 expression stimulation in oligodendrocyte progenitor cells inducing proliferation of these cells, mainly through Cx47. PMID: 28278052
22. Neuroprotective mechanism of sevoflurane pre-conditioning might be associated with increased Erk1/2 phosphorylation in mitochondria via inhibition of mPTP opening in the early reperfusion period PMID: 28017206
23. Rap guanine nucleotide exchange factors Epac1 and Epac2 induces the phosphorylation of extracellular signal-regulated kinases ERK1/2 in pituitary tumor GH3 cells. PMID: 28216156
24. Alisol A 24-acetate effectively reverses the phenotypic transformation and inhibits the migration of vascular smooth muscle cells, which may be associated with the suppression of the ERK1/2 signaling pathway. PMID: 27924795
25. Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRbeta phosphorylation in a time- and concentration-dependent manner. Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. PMID: 27400779
26. Enriched environment could promote rehabilitation after cerebral ischemia via regulation of p-ERK1/2 expression. PMID: 27068861
27. Paridis rhizoma sapoinins attenuate CCl4-induced liver fibrosis through the regulation of RASAL1/ERK1/2 signal pathway. PMID: 27396351
28. Data indicate that mitogen activated protein kinases c-Jun N-terminal kinase, p38, and ERK1/2 were activated but with different distributing patterns in the placenta. PMID: 26491907
29. Data show that N-acetylcysteine modulates mitogen activated protein kinase s ERK1/2 and NF-kappa B signaling pathways in soleus muscle of heart failure (HF). PMID: 27351177
30. Bisphenol A may promote proliferation of and collagen production by cardiac fibroblasts via activation ERK1/2 signaling pathway. PMID: 27025157
31. MEK-ERK1-2 pathway is involved in regulating the anti-oxidant strategies to compensate the oxidative status induced by diesel exhaust particle exposure. PMID: 27091075
32. Erk1 can be considered a proto-oncogene and that Erk molecules possess unusual autoregulatory properties, some of them independent of TEY phosphorylation. PMID: 26658610
33. The ERK1 in the insular cortex as a part of pathophysiological process that determines predisposition of Krushinsky-Molodkina rats to audiogenic seizures. PMID: 26923581
34. Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1/2 MAPK pathway. PMID: 26467923
35. Surviving CA1 pyramidal cells were identified by hematoxylin and eosin staining and the levels of phosphorylated ERK1/2, P38MAPK and JNK were detected by western blotting. PMID: 26549199
36. CaSR might play significant roles in the induction of hippocampus apoptosis in rat during hypoxia/reoxygenation through phosphorylation of ERK1/2. PMID: 26617793
37. TGF-beta1 antagonizes TNF-alpha induced up-regulation of matrix metalloproteinase 3 in nucleus pulposus cells: role of the ERK1/2 pathway. PMID: 26075533
38. The effects of combinative early and delayed ischemic postconditioning on producing brain BDNF in ischemia may be mediated by the activation of ERK1/2 and CREB. PMID: 26398857
39. it was shown that HCQ is protective via enhanced phosphorylation of the pro-survival kinase ERK1/2. PMID: 26636577
40. This study showed that sharp increases in phosphorylated or activated ERK1 was observed at postnatal day (PND) 7 in the SN and VTA. In contrast, in the STR, the levels of phosphorylated ERK1 was significantly higher at postnatal 0 day. PMID: 26363522
41. inhibition of ERK1/2 activation has no therapeutic effect on kidney fibrosis in SNx possibly due to increased compensatory activation of the p38 and JNK signalling pathways with subsequent upregulation of PAI-1. PMID: 26415098
42. overexpression of ERp29 in cortical neurons after axotomy increased expression of Erk-1 and PI3K while decreasing the expression of caspase-3 expression. PMID: 25204493
43. in the native GH3 cell system, ERK and RSK are involved in the pathway linking TRH receptor to r-ERG channel inhibition, but additional components must participate to cause such inhibition. PMID: 26022182
44. The expression of Cx43 contributes to aldosterone-induced mesangial cell proliferation via the ERK1/2 and protein kinase C pathways. PMID: 26138882
45. Data show that the simultaneous presence of G-protein-coupled receptor 30 (GPR30) and estrogen receptor alpha (ERalpha) is required for the action of peptide ERalpha17p activation of ERK1/2 (extracellular-signal-regulated kinase 1/2). PMID: 26371374
46. Enhanced NOX4 expression results in cardiac fibrosis through reactive oxygen species-ERK1/2-MAP kinase-dependent mechanisms in diabetic cardiomyopathy. PMID: 26088607
47. ERK1/ERK2 activity mainly in the glutamategic neurons of the hippocampus and the temporal cortex is a positive regulator of glutamate release that results in the initiation of auditory seizures. PMID: 26827493
48. The expression of DUSP6 and DUSP7 is mediated by ERK1/ERK2 activity in microglia. PMID: 26435497
49. both AKT and ERK1/2 pathways are crucial for the carotid body intracellular signaling process in response to hypoxia. PMID: 26303491
50. The results are indicative of a novel role of ERK1/2 in glucose-regulated POMC expression and offer new mechanistic insights into hypothalamic glucose sensing. PMID: 25624461

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KEGG: rno:50689

STRING: 10116.ENSRNOP00000026627

UniGene: Rn.2592