Recombinant Rat Monocarboxylate transporter 1 (Slc16a1), partial

1. 7ACC2 is an inhibitor of mitochondrial pyruvate transport; the blockade of pyruvate import into mitochondria prevents extracellular lactate uptake as efficiently as a MCT1 inhibitor PMID: 29572438
2. Following cerebral ischemia, monocarboxylate transporter 1 (MCT1) expression was upregulated in the peri-infarct striatum but not in the cortex of the brain. In vitro ischemia models were used to induce oligodendrocyte stress as well. An increase in MCT1 expression was detected in oligodendrocyte precursor cells after a mild oxygen-glucose deprivation. PMID: 29205833
3. The MCT1 mRNA and membrane protein expression varied with estrous cycle stage, with OVX females having higher expression than males, indicating that female sex hormones may play a role in MCT1 regulation. PMID: 29249221
4. Our results are proposing that in the developing brain white matter, MCT1 is predominately expressed in oligodendrocyte though it mainly expressed in astrocyte in early postnatal, which indicate that MCT1 may involve in the oligodendrocyte development and myelination. PMID: 27982679
5. Decreased expression of MCT1/4 in distal airway epithelium may disrupt lung branching morphogenesis and thus contribute to the development of pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model. PMID: 26996590
6. The transport mechanism of 4-PBA from blood to brain across the BBB likely involves MCT1. PMID: 27026010
7. The Canonical Wnt/beta-Catenin Pathway Increased Expression of MCT1 on the Plasma Membrane of Rat Brain Endothelial Cells. PMID: 26872974
8. MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation. PMID: 26831515
9. results suggest that the EA treatments activated lactate metabolism in the resident astrocytes around the ischemic area and up-regulated the expression of MCT1 in these astrocytes which facilitated the transfer of intracellular lactate PMID: 26037401
10. The metabolic Km for L-lactate closely resembled that for MCT-mediated hepatic uptake in vitro PMID: 24854892
11. After a 2-h exercise session, MCT1 increased in the cortex and hippocampus 5h postexercise. PMID: 24610532
12. Cyclic AMP signaling reduces the functionality of Mct1 in cerebrovascular endothelial cells. PMID: 24454947
13. Results suggest that acute exercise-induced increases in MCT1 and MCT4 mRNA expression may be possibly mediated by AMPK activation, at least in part in fast-twitch muscle. PMID: 23886299
14. These data indicate that MCT1 is the high affinity lactate transporter and MCT4 is the high affinity butyrate transporter in the intestinal epithelial cell line IEC-18. PMID: 23344966
15. we show for the first time the regulated and unregulated vesicular trafficking of Mct1 in cerebrovascular endothelial cells; processes which have significance for better understanding normal brain energy metabolism PMID: 22925948
16. MCT1 was lost on microvessels and upregulated on astrocytes in the hippocampal formation in all models of temporal lobe epilepsy. PMID: 21856423
17. MCT1 is increased at all ages, occurring 5-10-fold more in adult than in immature rats with status epilepticus. PMID: 21624469
18. Transfer of nicotinate from blood to retina across the inner blood-retinal barrier occurs primarily via H(+)-coupled monocarboxylate transporters. PMID: 21741392
19. MCT1 expression was doubled (P PMID: 21605500
20. Administration of Phellinus linteus increased endurance exercise performance through inhibition of serotonin production in the brain and increased the expression of MCT1 and MCT4 in muscles. PMID: 21512297
21. tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. PMID: 21297988
22. we characterized the effects of intracellular pH in controlling MCT1 function PMID: 21192921
23. Disrupting the expression of the astrocytic lactate transporters monocarboxylate transporter 4 (MCT4) or MCT1 causes amnesia, which, like long-term potentiation impairment, is rescued by L-lactate but not equicaloric glucose. PMID: 21376239
24. MCT1 and MCT2 are inhibited by AR-C155858, which binds to an intracellular site involving transmembrane helices 7-10 PMID: 19929853
25. Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia. PMID: 11896024
26. Muscle contraction increases lactate transport while reducing sarcolemmal MCT4, but not MCT1. PMID: 11934671
27. These studies have shown that 1) with STZ-induced diabetes, MCT1 (Slc16a1) and MCT4 (Slc16a4) are reduced in skeletal muscle and/or the heart and 2) exercise training alleviated these diabetes-induced reductions. PMID: 12611763
28. T3 thyroid hormone regulates MCT4, but not MCT1, protein expression and increases lactate transport rates. PMID: 12900382
29. The loop between helix 4 and helix 5 in MCT1 is important for transport activity. PMID: 12946269
30. Expression of the monocarboxylate transporter MCT1 in the rat brain between embryonic day 16 and postnatal day 14 produced MCT1-like immunoreactivity throughout the cortical anlage, particularly in the hippocampal anlage next to the ventricle. PMID: 12966567
31. monocarboxylic acid transporter 1 and 2 levels in the adult brain implies a major role for these proteins to transfer glycolytic intermediates during cerebral energy metabolism PMID: 14534079
32. A close correlation was found between local MCT1 and local GLUT1 densities. As local GLUT1 densities reflect local glucose metabolism in the brain, we conclude that local MCT1 densities are adjusted to local glucose metabolism and transport. PMID: 14729246
33. MCT1 and MCT4 belong to a class of selected metabolic genes that are very rapidly up-regulated with an exercise stimulus. PMID: 15388779
34. This T-cell-mediated regulation of MCT1 might contribute to a compensatory or protective mechanism in order to guarantee substrate pools for neurons and oligodendrocytes under inflammatory conditions. PMID: 15390096
35. inhibition of MCT1 and MCT4 activity by pCMBS is mediated through its binding to CD147, acting as an ancillary protein required to maintain the catalytic activity of MCTs 1 and 4, as well as for their translocation to the plasma membrane PMID: 15917240
36. MCT1 and COX are co-localised at both interfibrillar and subsarcolemmal cell domains in skeletal muscle PMID: 15932892
37. carbonic anhydrase enhances MCT1 transport activity, independent of its enzymatic reaction center, presumably by binding to MCT1 PMID: 16174776
38. monocarboxylic acid transporter-1 kinetic function is modulated by the cAMP signaling pathway in rat brain endothelial c PMID: 16301311
39. Western blots showed that cytochrome oxidase (COX), NADH dehydrogenase, LDH, MCT1, and CD147 are abundant in mitochondrial fractions of L6 cells. Interactions among COX, MCT1, and CD147 in mitochondria were confirmed by immunoblotting. PMID: 16434551
40. Our findings support the hypothesis that the expression of monocarboxylate transporter 1 and monocarboxylate transporter 4 in excitable tissues is regulated by activity. PMID: 16446038
41. In conclusion, MCT1 expression was up-regulated in hepatocarcinoma cells and the IGF-IR signaling appeared to be coupled with the modulation of MCT1 expression. PMID: 16516162
42. In conclusion, these studies have shown that testosterone induces an increase in both MCT1 and MCT4 proteins and their plasmalemmal content in skeletal muscle. PMID: 16959859
43. We propose that TM3 of MCT1 lies alongside the TM of basigin with Arg86 adjacent to Glu218 of basigin. PMID: 17127621
44. The correlation between MCT1 and NBC expression suggests that lactate transport may be facilitated by NBC in oxidative skeletal muscle, which may in turn favor better muscle pH regulation. PMID: 17609257
45. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. PMID: 18375207
46. MCT1 belongs to the family of metabolic genes whose expression is regulated by PGC-1alpha in skeletal muscle. PMID: 18523157
47. MCT1 transporters were up-regulated during chronic hyperglycemia at the level of brain substructures and independently of local cerebral glucose utilization PMID: 19118535
48. Dietary pectin up-regulates monocaboxylate transporter 1 in the rat gastrointestinal tract. PMID: 19168540
49. Increased MCT1 mRNA expression was detected in the injured cortex and hippocampus of animals with focal ischemia PMID: 19401710
50. It is concluded that MCT1 transporters were upregulated during chronic nicotine infusion at the level of brain substructures and, at least partially, independently of LCGU. PMID: 19433117

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KEGG: rno:25027

STRING: 10116.ENSRNOP00000027234

UniGene: Rn.6085