Recombinant Rat Nasal embryonic luteinizing hormone-releasing hormone factor (Nelf)

Code CSB-YP884119RA
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Source Yeast
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Code CSB-EP884119RA
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Source E.coli
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Code CSB-EP884119RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP884119RA
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Source Baculovirus
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Code CSB-MP884119RA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Nsmf
Uniprot No.
Alternative Names
Nsmf; Jac; Nelf; NMDA receptor synaptonuclear signaling and neuronal migration factor; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Jacob protein; Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
Species
Rattus norvegicus (Rat)
Expression Region
2-532
Target Protein Sequence
GAAASRRRA LRSEAMSSVA AKVRAARAFG EYLSQSHPEN RNGADHLLAD AYSGHEGSPE MQPAPHNKRR LSLVSNGRYE GSISDEAVSG KTATEGPQPR VYTISREPAL LPGSEAEAIE LAVVKGRRQR ERHPHHHSQP LRASPGSSRE DISRPCQSWA GSRQGSKECP GCAKLVPGPS PRAFGLEQPP LPEASGRHKK LERMYSVDGV SDDVPIRTWF PKENPFSFQT ATTTMQAISV FRGYAERKRR KRENDSASVI QRNFRKHLRM VGSRRVKAQT FAERRERSFS RSWSDPTPMK ADTSHDSRDS SDLQSSHCTL DEACEDLDWD TEKGLEATAC DTEGFLPPKV MLISSKVPKA EYIPTIIRRD DPSIIPILYD HEHATFEDIL EEIEKKLNIY HKGAKIWKML IFCQGGPGHL YLLKNKVATF AKVEKEEDMI HFWKRLSRLM SKVNPEPNVI HIMGCYILGN PNGEKLFQNL RTLMTPYKVT FESPLELSAQ GKQMIETYFD FRLYRLWKSR QHSKLLDFDD VL
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
Gene References into Functions
  1. Nsmf is a novel myogenic factor that can enhance myoblast proliferation. PMID: 25248434
  2. data support a synaptic and nuclear role of Jacob that implicates long-distance NMDAR signaling to the nucleus in excitatory neurons PMID: 23539133
  3. Study demonstrates that Jacob is a protein messenger that encodes the origin of synaptic versus extrasynaptic N-methyl-D-aspartate-receptors signals and delivers them to the nucleus. PMID: 23452857
  4. Nuclear translocation of jacob in hippocampal neurons after stimuli inducing long-term potentiation but not long-term depression. PMID: 21364755
  5. NELF controls overall immediate early gene transcription via multiple mechanisms both directly and indirectly. PMID: 19014935
  6. Results suggest that the transcription elongation factors NELF, DSIF and P-TEFb control constitutive transcription of the histone H1(0) and GAPDH genes. PMID: 19654008

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Subcellular Location
Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Membrane.
Protein Families
NSMF family
Tissue Specificity
Expressed in the radiatum and pyramidale strata of the hippocampus (at protein level). Strongly expressed in the brain. Expressed in the sensory and motor cortex, hippocampus, olfactory bulb, thalamus and amygdala. In the olfactory bulb expressed in the g
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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