Recombinant Rat Natural resistance-associated macrophage protein 2 (Slc11a2), partial

1. DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition. PMID: 29317744
2. impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Taken together, impaired these intestinal iron transporters may become a novel therapeutic target for cardio-renal anemia syndrome. PMID: 28669019
3. Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption PMID: 27331785
4. DMT1 and FPN1 are positively influenced by ferrous iron status in brain after intracerebral hemorrhage. DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export. PMID: 26617777
5. work unveils the role of DMT1 in mediating the neuroregenerative action of iron. PMID: 26360295
6. These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction. PMID: 26506412
7. the effects of hepcidin expression and hepcidin peptide on brain iron contents, iron transport across the brain-blood barrier, iron uptake and release, and also the expression of TfR1, DMT1, and Fpn, were investigated. PMID: 25115800
8. DMT1 expression was enhanced in the bone tissue of type 2 diabetic rats, and plays an important role in the pathological process of diabetic osteoporosis. PMID: 26078704
9. Goat milk consumption potentiates liver DMT1 expression, enhancing Fe metabolism and storage. PMID: 24239078
10. Hepcidin or enterocyte iron levels may be involved in the regulation of the age-dependent expression in the duodenum. PMID: 25318588
11. Spinal peroxynitrite activates DMT1-iron responsive element, leading to abnormal iron accumulation in postoperative hyperalgesia. PMID: 25501899
12. Data suggest that expression of Dmt1/Slc11a2 in intestinal mucosa can be regulated by dietary factors; here, expression of Dmt1/Slc11a2 in mucosa of cecum is up-regulated by prebiotic supplement, inulin, in iron-deficiency anemia. PMID: 25745840
13. All three isoforms of DMT1 are selectively expressed in different cell populations within the cochlea and, additionally, demonstrate their cellular and subcellular distribution changes with development. PMID: 24318355
14. Dmt1 expression was significantly elevated through pro-inflammatory cytokines, whereas Ft expression was marginally increased. PMID: 24850829
15. DMT1 protein levels are down-regulated in iron-loaded liver and up-regulated in iron-deficient liver and heart. PMID: 23349308
16. DMT1 not only exports iron from endosomes, but also serves to import the metal into the mitochondria PMID: 24448823
17. DMT1 is a candidate for non-transferrin-bound iron uptake within the peripheral nervous system. PMID: 23361852
18. The data presented here establish for the first time a causal association between inflammation and iron accumulation in brain cells, probably promoted by changes in DMT1 and FPN1 expression and mediated in part by hepcidin. PMID: 23506423
19. Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increases duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold. PMID: 23447582
20. analysis of synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1) PMID: 22154351
21. These data indicate that CTR1, but not DMT1, plays an essential role in transporting Cu by the blood-CSF barrier in the choroid plexus PMID: 22465424
22. these results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier PMID: 22442359
23. Pulmonary inflammation can be modified by both DMT1 and iron status. PMID: 21278260
24. DMT1+IRE up-regulation can account for IRE/IRP-dependent 6-OHDA-induced iron accumulation initiated by 6-OHDA-induced intracellular oxidative stress and that increased levels of intracellular iron result in aggravated oxidative stress. PMID: 20125122
25. Suggest a novel mechanism of regulation of intestinal iron absorption based on inward and outward fluxes at both membrane domains, and repositioning of DMT1 and FPN between membrane and intracellular compartments as a function of iron supply. PMID: 20007457
26. Divalent metal transporter-1 is present on astrocytic end feet in contact with blood vessels, suggesting that it may be involved in uptake of iron from endothelial cells. PMID: 12429222
27. results demonstrated that DMT1 mRNAs expression in the heart is age-dependent and that two forms of DMT1 mRNAs both are regulated by iron on the post-transcriptional level only PMID: 12767048
28. modulation of renal DMT1 expression by dietary iron intake may influence renal iron excretion rate. PMID: 12876064
29. in iron deficiency DMT-1 and mobilferrin concentrated in apical surface of villae. increase due to increased binding to mucin in vesicles near surface; localized in goblet cells and outside cell in luminal mucin. PMID: 12949888
30. At day 20, DMT1 increased fourfold and FPN1 increased eightfold in the low-Fe group. Molecular mechanisms regulating iron absorption during early infancy differ from late infancy. PMID: 12958019
31. G185R mutation of DMT1 causes protein instability in the kidneys of b/b anemic rats. PMID: 14531808
32. Brain iron transport and distributional pattern of divalent metal transporter I (DMT1) were studied in homozygous Belgrade rats (b/b) which suffer from a mutation in the DMT1 gene; low cerebral iron uptake may derive from a reduced neuronal uptake PMID: 14675167
33. DMT-1 does not play a major role in brain manganese uptake; one or more carrier-mediated processes other than that of DMT-1 are primarily involved. PMID: 15019308
34. DMT1 may play a role in transporting iron between intracellular compartments in spermatogenic epithelium and thus may play an important role in male fertility. PMID: 15355847
35. high-resolution structures of a synthetic peptide, corresponding to the sequence of the fourth transmembrane domain of rat DMT1 with G185D mutation PMID: 15660380
36. Immunofluorescent staining of thin sections of proximal intestines of b/b and +/b Belgrade rats confirms that DMT1 localizes similarly in mutant and control enterocytes and shows that DMT1 isoforms have distinct distributions within intestinal tissue. PMID: 15736955
37. Primary role for DMT1 in lung metal transport and detoxification. PMID: 15908475
38. Ferroportin antibody induced rapid turnover of membrane ferroportin & DMT1 & its internalisation to late endosomes, resulting in impaired Fe(II) uptake. PMID: 16075245
39. The molecular mechanism of iron transport by wild type and mutant DMT1 is reported. PMID: 16091957
40. renal proximal tubular cells express divalent metal transporter 1 (DMT1) in the membranes of organelles, including late endosomes/lysosomes, associated with processing of apically sequestered transferrin PMID: 16449358
41. Exposure of P19 cells to a NO precursor, resulted in a decrease in expression of both positive and negative IRE isoforms of DMT1 with no change in the 1A species. PMID: 16539692
42. Brain capillary endothelial cells probably mediate iron transport into the brain by segregating iron from transferrin without involvement of DMT1 PMID: 16879716
43. This study demonstrated that endosomal/lysosomal DMT1 plays a role in renal proximal tubule cadmium-methallothionein1 toxicity. PMID: 17596526
44. DMT1 function is not essential for iron assimilation from milk during early development in the rat. PMID: 17640977
45. rHuEpo injection reduced the peritoneal exudate macrophages iron retention. The uptake of Fe(II) was decreased via the suppression of DMT1 (+IRE) expression and the release of Fe(II) was increased with increasing the expression of FPN1 in macrophages. PMID: 18189270
46. Our findings also show that MPP(+)-induced apoptosis in MES23.5 cells involves DMT1-dependent iron influx and mitochondria dysfunction. PMID: 18191877
47. An increase in HO2 and DMT1 mRNA level was induced after chronic exposure to depleted uranium. PMID: 18375546
48. The up-regulation of DMT1-IRE and the increase in DMT1-IRE-mediated iron influx play a key role in L-DOPA neurotoxicity in cortical neurons PMID: 19240805

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KEGG: rno:25715

STRING: 10116.ENSRNOP00000026531

UniGene: Rn.11418