Recombinant Rat Netrin receptor UNC5C(Unc5c),partial

Code CSB-YP758823RA
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Source Yeast
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Code CSB-EP758823RA
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Source E.coli
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Code CSB-EP758823RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP758823RA
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Source Baculovirus
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Code CSB-MP758823RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Unc5c
Uniprot No. Q761X5
Alternative Names Unc5c; Unc5h3; Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C
Species Rattus norvegicus (Rat)
Protein Length Extracellular domain
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Gene References into Functions
  1. T835M (rs137875858) in UNC5C increased hippocampal neuronal cell death and susceptibility to neurotoxic stimuli. PMID: 25419706
  2. Both cvd and hob mutations are predicted to lead to truncated UNC5H3 proteins lacking their cytoplasmic region required for Netrin-Unc5h3 signaling pathway. Therefore, we conclude that Unc5h3 is causative gene of both cvd and hob mutant phenotypes. PMID: 15010202
Involvement in disease Defects in Unc5c are the cause of cerebellar vermis defect (cvd) and hobble (hob) phenotypes. Cvd and hob rats exhibit cerebellar and midbrain defects, possibly as a result of abnormal neuronal migration, and exhibit laminar structure abnormalities in the fused cerebellar hemispheres and ectopic cerebellar tissues in the cerebello-pontine junction.
Subcellular Location Cell membrane, Single-pass type I membrane protein, Cell junction, synapse, synaptosome
Protein Families Unc-5 family
Tissue Specificity Detected in brain (at protein level) (PubMed:22405201). Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.
Database Links

KEGG: rno:362049

STRING: 10116.ENSRNOP00000050380

UniGene: Rn.47255

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