Recombinant Rat Platelet-derived growth factor D (Pdgfd)

Code CSB-YP880633RA
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Source Yeast
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Code CSB-EP880633RA
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Source E.coli
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Code CSB-EP880633RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP880633RA
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Source Baculovirus
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Code CSB-MP880633RA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Pdgfd
Uniprot No.
Alternative Names
Pdgfd; Iegf; Scdgfb; Platelet-derived growth factor D; PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B) [Cleaved into: Platelet-derived growth factor D; latent form; PDGFD latent form); Platelet-derived growth factor D; receptor-binding form; PDGFD receptor-binding form)]
Species
Rattus norvegicus (Rat)
Expression Region
24-370
Target Protein Sequence
TPQSASI KALRNANLRR DESNHLTDLY RRDENIRVTG TGHVQSPRFP NSYPRNLLLT WRLHSQEKTR IQLAFDHQFG LEEAENDICR YDFVEVEDVS ESSTVVRGRW CGHKEIPPRI TSRTNQIKIT FQSDDYFVAK PGFKIYYSFV EDFQPEAASE INWESVTSSF SGVSYHSPSV MDSTLTADAL DKAIAEFDTV EDLLKYFNPA SWQDDLENLY MDTPRYRGRS YHERKSKVDL DRLNDDVKRY SCTPRNHSVN LREELKLTNA VFFPRCLLVQ RCGGNCGCGT LNWKSCTCSS GKTVKKYHEV LKFEPGHFKR RGKAKNMALV DIQLDHHERC DCICSSRPPR
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Gene References into Functions
  1. Podocyte-specific PDGF-D overexpression caused mesangioproliferative disease, glomerulosclerosis, and crescentic glomerulonephritis. Podocyte-specific PDGF-D overexpression induced paracrine mesangial cell proliferation upstream of the filtration flow. PMID: 21866094
  2. The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system PMID: 11850188
  3. PDGFD is expressed in the eye and has a key role in control of lens epithelial cell proliferation PMID: 15611105
  4. These results support the fact that PDGF-D is involved in the formation of neointimal hyperplasia induced by balloon catheter injury and may serve as a target in preventing vascular restenosis after coronary angioplasty. PMID: 15752751
  5. PDGF-D possesses potential pathogenetic properties for HSC activation and matrix remodeling in liver fibrosis PMID: 17397961
  6. All 3 residues in Sp1 (Thr668, Ser670, and Thr681) are required for Sp1-dependent platelet-derived growth factor-D activation in response to angiotensin II PMID: 18258854
  7. alloimmune response induces PDGF-A, PDGF-C, and PDGF-D expression in the graft vasculature;PDGF-D mediated profibrotic and proarteriosclerotic effects in transplanted hearts involving the TGF-[beta]1 pathway PMID: 19213942

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Subcellular Location
Secreted.
Protein Families
PDGF/VEGF growth factor family
Tissue Specificity
Widely expressed. Expressed at high levels in the kidney, adrenal glands, eye and CNS. In the kidney the localization is confined to arterial and arteriolar vascular smooth muscle cells and is also detected at low levels in the glomeruli In the eye in the
Database Links
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