Recombinant Rat Reelin (Reln), partial

1. Study found that reelin levels in the visual layers of the superior colliculus are the highest between the second and third postnatal weeks. Blocking reelin signaling with a neutralizing antibody (CR-50) from PND 7 to PND 14 induced a non-specific sprouting of ipsilateral retinocollicular axons outside their typical distribution of discrete patches of axon terminals. PMID: 28602919
2. Melatonin ameliorated the neurotoxiciy and astrocyte activation induced by Abeta1-42 in the cerebral cortex. Melatonin also blocked the reduction in Reelin and Dab1 expression induced by Abeta1-42. Using in vitro study, Reelin inactivation completely abolished the protective effect of melatonin against Abeta1-42-induced neurotoxicity. PMID: 28385118
3. These results indicate that reelin/ApoER2/PSD95 signaling is important for neuronal structure maintenance in mature neurons. PMID: 27653801
4. Golgi complex fragmentation and Reelin dysfunction are key contributors to neuronal cell death in the early stage of epilepsy pathophysiology. PMID: 25790952
5. we analyzed the effect of relin on the process morphology of primary rat astrocytes PMID: 27168410
6. Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats PMID: 25679528
7. Study shows presence of reelin immunolabeling in brain endothelial cells, and particularly in caveolar vesicles within these cells, suggests that reelin and/or reelin peptides may be able to cross the blood-brain barrier PMID: 25887698
8. This study present a multimodal dataset on Reln-positive patch-clamped neurons in layers I-IV of rat somatosensory (barrel) cortex. PMID: 23803971
9. The results suggest that reelin promotes microtubule assembly, at least in part, by increasing microtubule plus end dynamics. PMID: 22990595
10. distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development PMID: 24134921
11. we show that Reelin acts presynaptically, resulting in robust rapid enhancement of spontaneous neurotransmitter release PMID: 24210904
12. Data suggest that down-regulation of reelin expression in immature dentate granule cells/neurons plays role in the pathogenesis of major depression (in a rat model based on repeated exposure to the stress hormone corticosterone). PMID: 23608736
13. Hippocampal cytoarchitectural alterations and reelin deficiency may be involved in the development of remote cognitive impairments in this model PMID: 23478644
14. Data indicate that increased TIMP-1 levels inhibit the proteolytic processing of Reelin under epileptic conditions. PMID: 23493620
15. Reelin has important implications for the maternal-neonate interaction needed for normal brain development. PMID: 23385810
16. Reelin expressions in iodine-deficient & PTU-treated rats were significantly decreased on PND14 and 21. PMID: 22595232
17. These findings suggest that epigenetic regulation of DNA demethylation and histone acetylation of target genes, such as reelin, might underlie the mechanisms of synaptic plasticity and memory retention in the medial prefrontal cortex. PMID: 22469747
18. Reelin is expressed in distinct populations of pre-Botzinger complex neurons and inspiratory bulbospinal ventral respiratory group neurons. PMID: 21858819
19. Medial prefrontal cortex reelin signaling plays an important role in behavioral tasks with relevance to schizophrenia, for example. PMID: 21784155
20. These observations support a role for entorhinal reelin signaling in spatial learning, and suggest that an intact reelin signaling pathway is essential for synaptic integrity in the adult entorhinal cortex. PMID: 21492744
21. Maternal hypothyroidism-mediated cytoarchitecture defects including mispositioned neurons, altered morphology, and density of radial glia and loss of bipolarity of migrating neurons is attributed at least in part to reelin signaling cascade deficits. PMID: 20368265
22. secretion of Reelin is activity-independent and that proteolytic processing of Reelin is required for the maintenance of granule cell lamination in the dentate gyrus PMID: 21148112
23. This study suggested thatreduced reelin expression, emanating from layer II entorhinal neurons, may contribute to network dysfunction that occurs during memory loss in aging. PMID: 20538740
24. strong expression of estrogen receptor alpha was found in Cajal-Retzius (CR) cells, which regulate neuronal migration and synaptogenesis via the extracellular matrix protein reelin PMID: 20421250
25. Sustained increases of immature GABAergic interneurons synthesizing Reelin in the hilus could be a signature of compensatory regulation for impaired neurogenesis. PMID: 20347957
26. study found region-specific loss of reelin in the ventral dentate gyrus and its association with deficits in avoidance conditioning in adult animals that have been reared in isolation PMID: 20438765
27. investigation of reelin signalling system in intestinal mucosa; reelin protein was only observed in isolated intestinal fibroblasts & in a cell layer subjacent to the villus epithelium, which seems to be composed of myofibroblasts PMID: 19946030
28. Developmental emergence of neurobehavioural and reelin deficits in isolation reared animals is proposed to reflect maladaptive wiring within the medial prefrontal cortex during a critical maturation period of this circuitry. PMID: 20035841
29. reelin has a role in PI3-kinase signaling in neuronal growth cones, and in contributes to final neuron positioning in the mammalian brain by local modulation of protein kinase B and glycogen synthase kinase 3beta kinase activities PMID: 12376533
30. The presence of three reelin forms (full-length 420 kD, 310 kD, and 180 kD) has been demonstrated in rat cerebrospinal fluid. PMID: 12645087
31. A nucleotide insertion mutation in Reelin causes a translational frameshift and results in truncation of the Reelin protein. This removes the C-terminal region required for Reelin secretion and function. PMID: 12670697
32. Reelin signaling stimulates Dab1 binding to PI3 kinase and has a role in normal cortical lamination PMID: 12882964
33. High levels of reelin product are detected in the lateral marginal and ventral ventricular zones of spinal cord; this expression pattern is detected at all segmental spinal cord levels during embryonic development. PMID: 14648677
34. The Reelin-expressing cells in the commissure systems are GABAergic neurons. Reelin-expressing neurons in the anterior commissure had many conspicuous varicosities on their dendritic arbors and mimic to the interfascicular neurons. PMID: 14757522
35. differentiation factor for radial glial cells of dentate gyrus and as a positional cue for radial fiber orientation PMID: 15459104
36. reelin, which is expressed along the route of the migrating GnRH neurons, has an inhibitory role in guiding GnRH neurons to the basal forebrain PMID: 16207762
37. Modulates dentate granule cell(DGC) progenitor migration to maintain normal DGC integration in neonatal and adult dentate gyrus. Loss in epileptic adult hippocampus may contribute to ectopic chain migration and aberrant integration of newborn DGCs. PMID: 17314278
38. data show that Reelin is up-regulated in experimental liver cirrhosis and that its levels, thereby supporting that Reelin is involved in the pathogenesis of liver disease. PMID: 18449964
39. The present results suggest that reelin was affected by a number of different psychotropic medications commonly used to treat schizophrenia, bipolar disorder, major depression, and autism. PMID: 19359144

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KEGG: rno:24718

STRING: 10116.ENSRNOP00000058574

UniGene: Rn.98353