Recombinant Rat Signal transducer and activator of transcription 5B (Stat5b)

1. Combinatorial interplay among multiple Stat5b-binding response elements with distinguishable biochemical properties is responsible for highly regulated control of IGF-I gene activity by growth hormone. PMID: 23185594
2. STAT5b plays an essential role in growth hormone signaling activation and osteoblast differentiation. PMID: 23071812
3. the inhibition of Stat5b expression in chondrocytes prevented the GH promoting effects on NF-kappaB-DNA binding, whereas the inhibition of NF-kappaB p65 expression or activity prevented the GH-dependent activation of IGF-1 and bmp2 expression. PMID: 21592969
4. GH stimulates recruitment of Stat5b to multiple dispersed regions within the IGFI locus PMID: 20378540
5. Insulin-like growth factor-I gene transcription is controlled by growth hormone through this protein PMID: 12682066
6. EGF induces tyrosine phosphorylation and DNA-binding activity of Stat5b in a manner different from GH and PRL, apparently by a Src-dependent mechanism PMID: 12767047
7. two intronic Stat5 DNA elements were able to bind Stat5b in vitro after GH treatment and could transmit GH- and Stat5b-dependent transcriptional responsiveness to the major IGF-I promoter PMID: 14532269
8. These results, in addition to establishing STAT5b as one of the key agents of GH-stimulated gene transcription, demonstrate the feasibility of using in vivo gene transfer to target the functions of hormone-activated signal transduction pathways. PMID: 14761873
9. phosphorylated Stat5b protein increases upon EPO stimulation in Leydig cells PMID: 15062567
10. The activation of STAT5B by prolactin was biphasic, with an initial peak within 30 min, a nadir between 1 and 3 h, and prolonged activation after 4 h, in contrast, the response to growth hormone was transient for 1 h. PMID: 15142985
11. growth hormone, via the coordinated action of HNFs and STAT5b, regulates sexually dimorphic liver gene expression [review] PMID: 15253383
12. Stat5b A630P mutant is an inactive transcription factor by virtue of its aberrant folding and diminished solubility triggered by a misfolded SH2 domain. PMID: 16303763
13. specific Stat5b binding sites mediate growth hormone-stimulated IGF-I gene transcription PMID: 16339156
14. STAT-5B/STAT-3/Hsp27/FGF-2 signaling via its involvement in the regulation of vascular smooth muscle growth growth and motility may play an important role in the pathogenesis of vascular disease. PMID: 16527988
15. around the end of pregnancy, prolactin loses the ability to activate STAT5b PMID: 16857756
16. suppressor of cytokine signaling 2 is a direct signal transducer and activator of transcription 5b target in liver PMID: 17008382
17. The cellular actions of GH normally mediated by activation of the Jak2/Stat5B pathway are suppressed in female cells. PMID: 17332060
18. Immuno-blot analysis revealed the highest nuclear level of STAT5b in the fetus and during postnatal development, whereas in the adult it decreased. PMID: 17565389
19. STAT2/5a/5b/6 were confirmed to be significantly modulated during focal cerebral ischaemia. PMID: 17880360

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KEGG: rno:25126

STRING: 10116.ENSRNOP00000026354

UniGene: Rn.54486