Recombinant Rat Somatotropin (Gh1)

1. IGF1 exerts a negative feedback on GH secretion by a transcriptional mechanism. PMID: 29080043
2. The results suggest that GH regulates energy metabolism directly in myocytes and that UCP2 participates in the signal transduction pathway that functions downstream of the GHR/JAK/STAT. PMID: 27150070
3. Impaired growth hormone-mediated signaling is observed in ethanol-exposed hepatocytes and is explained by differential effects of alcohol dehydrogenase (ADH)- and cytochrome P450 2E1 (CYP2E1)-mediated ethanol metabolism on the Jak2/STAT5B pathway. PMID: 28864499
4. l-Ornithine stimulates growth hormone secretion through the sympathetic nervous and ghrelin systems. PMID: 28513740
5. This study evaluated the role of growth hormone in the response to exogenous epidermal growth factor. PMID: 28223314
6. This study indicates that the depressive-like behavior may be related to the decrease of Gh1 expression in the cerebellum and prefrontal cortex. PMID: 25716693
7. estrogen deficiency impairs the induction of thyroid hormone activating enzyme D1 in the pituitary, and GH release by acute exercise. Also, acute D1 activation is essential for exercise-induced GH response PMID: 25874614
8. constitutive SSTR3 activity mediates transcriptional repression of GH. PMID: 24606125
9. GH serum concentration fell, with a modification of GH daily pattern after mealtime PMID: 24617825
10. Linear growth impairment in chronic kidney disease can in part be explained by impaired long bone growth plate growth hormone receptor signaling through the JAK2/STAT5 pathway. PMID: 23715123
11. A novel missense substitution single nucleotide polymorphism identified in the GH1 gene of Wistar-Imamichi rats. PMID: 24338415
12. Data from mutant strain of rats suggest that ghrelin (Ghrl) participates in neurogenesis in adult hippocampus and leads to enhancement of cognitive function in mechanisms that are independent of growth hormone and insulin-like growth factor-1 (Igf1). PMID: 23774069
13. This study compared the effect of a single IV bolus of a related molecule developed for clinical studies SXN101959 with a SC infusion of the somatostatin analog octreotide SMS201-995 to lower GH/IGF-I activity in growing male rats. PMID: 24029240
14. CR-associated remodeling of WAT, which involves SREBP-1-mediated transcriptional activation and suppression of macrophage infiltration, is regulated in a GH-IGF-1-independent manner. PMID: 22645024
15. GH increased the levels of glial fibrillary acidic protein (GFAP) and decreased the levels of vimentin. PMID: 23792323
16. Data show alterations in growth hormone (GH) synthesis and expression of GH-releasing hormone receptor (GHRH receptor) on cells of the immune system that may play a role in the immune response in aging. PMID: 23770714
17. Data indicate a putative hypoxia response element (HRE) in the growth hormone (GH) promoter at the region -176 bp to -172 bp that contains a copy of the hypoxia-inducible factor-1 (Hif-1) binding motif (5'-ACGTG-3'). PMID: 23639351
18. an important role of growth cartilage GH/IGF-I axis regulation in a rat model of catch-up growth. PMID: 22583947
19. Combinatorial interplay among multiple Stat5b-binding response elements with distinguishable biochemical properties is responsible for highly regulated control of IGF-I gene activity by growth hormone. PMID: 23185594
20. in the absence of pituitary growth hormone the postnatal proliferation of cholinergic synapses in the rat spinal cord where AChE activity is abundant, is markedly reduced PMID: 22922167
21. Chronic hypoxia induced decreases in serum growth hormone/Igf1 may be slightly attenuated by exercise/docosahexaenoic acid supplementation. PMID: 22865430
22. analysis of enhanced oxidative stress in GH-transgenic rat PMID: 22370764
23. GH/IGF-1 deficiency rendered the cardiovascular system more vulnerable to the deleterious effects of obesity. Lewis dwarf rats had a relative increase in blood glucose levels, lower insulin, and impaired glucose tolerance as compared with controls. PMID: 22080499
24. The inhibitory effects of EGF on GH expression are mediated by MAPK activation in these cells. PMID: 22026435
25. Data suggest that inductive/repressive effects of GH on hepatic P450 enzymes (i.e., steroid hydroxylases) are all exerted at transcriptional level; inductive/repressive effects of continuous presence of GH are direct effects on hepatocytes. [REVIEW] PMID: 22217849
26. the inhibition of Stat5b expression in chondrocytes prevented the GH promoting effects on NF-kappaB-DNA binding, whereas the inhibition of NF-kappaB p65 expression or activity prevented the GH-dependent activation of IGF-1 and bmp2 expression. PMID: 21592969
27. involvement of the GH/IGF-1 axis in the effect of CR for stress response, even if CR does not act solely through the GH axis. PMID: 21291903
28. Growth hormone gene expression rises in the pituitary, while its receptor mRNA level in the hypothalamus decreases. PMID: 20814072
29. GH stimulates recruitment of Stat5b to multiple dispersed regions within the IGFI locus PMID: 20378540
30. This study investigated the: eEF1A and GH mRNA binding to cytoskeleton plus GH mRNA translation rate and GH secretion, in sham-operated and thyroidectomized rats treated with triiodothyronine or saline. PMID: 20015464
31. data show that growth hormone is specifically imported in mitochondria, where it operates a direct metabolic effect, independently of cell surface receptors and signal transduction PMID: 20016135
32. Bcl6 and STAT5 binding are inversely coordinated by the endogenous pulses of pituitary GH release, suggesting this male-specific transcriptional repressor modulates hepatic GH signaling to select STAT5 target genes PMID: 19797429
33. GH and its receptor have roles in injury-induced neurogenesis PMID: 19524466
34. evaluate the influence of GH deficiency on the skin nature, age-related changes in the dorsal skin histology were compared between male Mini and Wistar rats PMID: 11962746
35. gene expression of GH and GHR mRNA in isolated oocytes and follicular wall cells of pre-antral follicles; localisation of immunoreactive IGF-I, IGFR, GH and GHR proteins in ovarian sections of 10-day-old rats PMID: 11964096
36. role for GH signaling in the pathogenesis of early diabetic renal changes PMID: 12086960
37. GH administration desensitizes the JAK2/STAT5 pathway PMID: 12161450
38. study demonstrates that leptin but not growth hormone or insulin-like growth factor-I is involved in the development of insulin resistance in growing rats as a result of excess energy intake in the form of dietary fat PMID: 12624434
39. endogenous pituitary GH exerts a feedback action on stomach ghrelin homeostasis PMID: 14530511
40. critical components of GH-activated IGF-I, transcriptional pathway are two adjacent Stat5 binding sites in the second intron of the IGF-I gene located within a conserved region previously found to undergo changes in chromatin structure after GH treatment PMID: 14532269
41. With IGF-I, contributes to changes in bone density and male reproductive organs. PMID: 15223841
42. GH plays an important role in establishing the sex-dependent differences in liver nuclear protein content in rats PMID: 15456855
43. functional recycling of retained hormones is not shared by all anterior pituitary cell types PMID: 15480745
44. B, non T-non B, and CD4+-CD8+ cells correlated negatively with plasma prolactin. Modifications in mean value and 24-h rhythmicity of plasma prolactin and GH levels are presumably involved in the effect of social isolation on immune responsiveness. PMID: 15545705
45. AGRP does not play a significant role in the feedback regulation of the GH secretion PMID: 15582725
46. GH and IGF-I necessary for reproduction and growth of offspring early in life and for maintaining cognition and preventing cartilage degeneration later in life. PMID: 15790724
47. Data show that cholangiocytes respond to growth hormone with production and release of IGF1 that modulates cell proliferation by transduction pathways involving IGF1-R, IRS1/2 and both ERK and PI3-kinase. PMID: 16083987
48. hypoxia (continually or intermittently), restraint, cold alone or in combination modulate pituitary GH and hepatic IGF-I PMID: 16139950
49. insulin may be necessary for sensitization of cells to GH-induced ERK1/2 activation in rat cells PMID: 16272159
50. These results indicate that maternal exercise significantly increases plasma levels of GH, IGF-I and IGFBP-3 in the late period of pregnancy but causes adverse effects on fetal growth. PMID: 16340176

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KEGG: rno:24391

STRING: 10116.ENSRNOP00000015818

UniGene: Rn.146351